General Research InterestTransplant Immunology, Hepatocyte Immunobiology, Hepatocyte Transplantation, Alloantibody, Liver Immunity, Pancreatic Islet Cell Transplantation, Constimulation, T cell Activation, Cytotoxic Effector Function, Adhesion Molecules, Mechanisms of Rejection and Immune Tolerance.
Research DescriptionDr. Ginny Bumgardner continues her investigations in transplant immunobiology, using experimental models of pancreatic islet and hepatocyte (liver cell) transplantation. Studies include a research project that focuses on understanding how a novel CD8+ T cell-dependent pathway is activated after transplant, and how its activation and effector function can be suppressed by immunotherapy in primary and sensitized transplant recipients. This pathway is important, because it can cause transplant tissue damage, either early or late after transplant, and interferes with the induction of transplantation tolerance.
Transinstitutional WorkDr. Ginny Bumgardner is the Associate Dean for Research Education & Graduate Studies in the College of Medicine. Dr. Bumgardner is a member of the Executive Committee of the Medical Scientist Program (MSP), the M.D./ Ph.D. dual degree program. Dr. Bumgardner is a faculty member in the Integrated Biomedical Sciences Graduate Program. She participates as a member of the OSU Clinical and Translational Science (CCTS) Community of Research Education. Dr. Bumgardner serves as the Director of the COM’s Masters of Medical Science Program