Ginny Bumgardner L MD, PhD, FACS

Ginny Bumgardner L MD, PhD, FACS
ProfessorCollege of Medicinebumgardner.9@osu.edu
166 Twelfth Avenue, 395 West 395 W 12th Avenue Columbus Ohio 43210
Phone:614-293-8545Fax: (614) 293-4541
  • Non-Member

General Research Interest

Transplant Immunology, Hepatocyte Immunobiology, Hepatocyte Transplantation, Alloantibody, Liver Immunity, Pancreatic Islet Cell Transplantation, Constimulation, T cell Activation, Cytotoxic Effector Function, Adhesion Molecules, Mechanisms of Rejection and Immune Tolerance.

Research Description

Dr. Ginny Bumgardner continues her investigations in transplant immunobiology, using experimental models of pancreatic islet and hepatocyte (liver cell) transplantation. Studies include a research project that focuses on understanding how a novel CD8+ T cell-dependent pathway is activated after transplant, and how its activation and effector function can be suppressed by immunotherapy in primary and sensitized transplant recipients. This pathway is important, because it can cause transplant tissue damage, either early or late after transplant, and interferes with the induction of transplantation tolerance. 

Transinstitutional Work

Dr. Ginny Bumgardner is the Associate Dean for Research Education & Graduate Studies in the College of Medicine. Dr. Bumgardner is a member of the Executive Committee of the Medical Scientist Program (MSP), the M.D./ Ph.D. dual degree program. Dr. Bumgardner is a faculty member in the Integrated Biomedical Sciences Graduate Program.  She participates as a member of the OSU Clinical and Translational Science (CCTS) Community of Research Education. Dr. Bumgardner serves as the Director of the COM’s Masters of Medical Science Program

Current Publications

  • Zimmerer JM, Horne PH, Fiessinger LA, Fisher MG, Jayashankar K, Garcia SF, Abdel-Rasoul M, van Rooijen N, Bumgardner GLInhibition of recall responses through complementary therapies targeting CD8+ T-cell- and alloantibody-dependent allocytotoxicity in sensitized transplant recipients.Cell Transplant 22 1157-69 1/1/2013
  • Zimmerer JM, Horne PH, Fiessinger LA, Fisher MG, Pham TA, Saklayen SL, Bumgardner GLCytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR.Transplantation 94 1103-10 12/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu