Clay B Marsh MD

Clay B Marsh MD
Vice DeanCollege of Medicinemarsh.2@osu.edu
5th Floor McCampbell Hall North 1581 Dodd Drive Columbus Ohio 43210
Phone:614-293-9309Fax: 614-292-4499
  • Innate Immunity

General Research Interest

My laboratory focuses on translational research in the area of macrophage biology, focusing on pulmonary fibrosis and tissue microenvironment/angiogenesis (including application to breast cancer and melanoma). We are also interested at understanding human health and disease using genetic/genomic applications.

Research Description

Focusing on the mechanisms underlying human health and disease, we have projects ranging from biomarker discovery using microRNA molecules to define genetic pathways and proteins important in tissue environments including breast cancer, lung cancer, lung fibrosis, and melanoma; cell biology studying the growth factors macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and mononuclear phagocytes in tissue environments including breast cancer, melanoma; stress pathways and human disease; and systems biology approaches to defining what networks underlie health. My laboratory is divided into five modules: 1) Systems biology/medicine genetics in human health and disease; 2) Signaling and cell survival/differentiation; 3) Lung repair and remodeling; 4) Angiogenesis in breast cancer and melanoma; 5) Stress and depression in human health, aging and disease; 6) Translational Research in pulmonary fibrosis and breast cancer.

Transinstitutional Work

Our lab collaborates with other individuals throughout medical center, university and industry such as in the area of systems biology where we are collaborating with Battelle and the Institute for Systems Biology (Seattle, Washington) in understanding gene and microRNA expression in lung diseases including pulmonary fibrosis. In collaboration with Dr Tim Huang and Dr Michael Ostrowski, both in the Division of Molecular Virology Immunology and Medical Genetics we are investigating, respectively, the role of DNA methylation and the ability to alter gene expression and the role of transcription factors including Ets1 to regular expression of genes associated with pulmonary fibrosis. We are also working with Dr Christopher Kaeding in the Department of Orthopedics applying our current ability to identify microvesicle subpopulations in the peripheral blood and microRNA content contained within the vesicles as a prognostic factor in ACL injuries. Our lab is also working with Dr Chandan Sen, Department of Surgery, evaluating both serum and leukocytes from wound healing patients to construct a ‘healing’ cytokine expression profile for diabetic patients with hard-to-heal wounds. With Dr Ronald Glaser from the Institute for Behavioral Medicine we are performing studies to identify the effects of restraint stress on malignant melanoma and the effects of stress on the development and progression of lung diseases. Collaboration with investigators within our division include working with Dr Narasimham Parinandi on the effects of methyl mercury and Vitamin C on blood vessel development and integrity), and Dr Valery Khramstov on the development of novel soluble Ph, oxygen and glutathione nanoprobes for real-time in vivo evaluation of tumor microenvironment.

Current Publications

  • Justiniano SE, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda JM, Mo X, Cheney C, Hertlein E, Eubank TD, Marsh C, Muthusamy N, Butchar JP, Byrd JC, Tridandapani SFcγ receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.J Biol Chem 288(37) 26800-9 9/13/2013
  • Dakhlallah D, Batte K, Wang Y, Cantemir-Stone CZ, Yan P, Nuovo G, Mikhail A, Hitchcock CL, Wright VP, Nana-Sinkam P, Piper MG, Marsh CBEpigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis.Am J Respir Crit Care Med 187(4) 397-405 2/15/2013
  • Ismail N, Wang Y, Dakhlallah D, Moldovan L, Agarwal K, Batte K, Shah P, Wisler J, Eubank TD, Tridandapani S, Paulaitis ME, Piper MG, Marsh CBMacrophage microvesicles induce macrophage differentiation and miR-223 transfer.Blood 121(6) 984-95 2/7/2013
  • Chen D, Roda JM, Marsh CB, Eubank TD, Friedman AHypoxia inducible factors-mediated inhibition of cancer by GM-CSF: a mathematical model.Bull Math Biol 74(11) 2752-77 11/1/2012
  • Roda JM, Wang Y, Sumner LA, Phillips GS, Marsh CB, Eubank TDStabilization of HIF-2α induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth in a murine melanoma model.J Immunol 189(6) 3168-77 9/15/2012
  • Szomolay B, Eubank TD, Roberts RD, Marsh CB, Friedman AModeling the inhibition of breast cancer growth by GM-CSF.J Theor Biol 303 141-51 6/21/2012
  • Bobko AA, Eubank TD, Voorhees JL, Efimova OV, Kirilyuk IA, Petryakov S, Trofimiov DG, Marsh CB, Zweier JL, Grigor'ev IA, Samouilov A, Khramtsov VVIn vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors.Magn Reson Med 67(6) 1827-36 6/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu