Susan D. Moffatt-Bruce MD
General Research InterestT cell immunology. The interaction of macrophages and T cells in lung cancer model.
Research DescriptionOur laboratory is interested in the role of T cells in the treatment of lung cancer. In particular, we are interested in investigating the role of T cells in patients that have both early and late lung cancer and received therapy in the form of photodynamic therapy. We use both a lung cancer model as well as human samples (07115) and are currently investigating the role of T regulatory cells in these patient that receive the therapy and will follow their survival. Additional studies will include investigating the role of macrophages in presenting antigen to the CD4 T cells and their response with and without treatment in patients with distinct stages of disease
Transinstitutional WorkThis work is a collaborative effort between the Divisions of Transplantation, Cardiothoracic Surgery and Surgical Oncology. As such, we plan on using the expertise gained in understanding the role of T cell biology in immune responses under varying treatment regimens. Whilst in transplantation we are interested in allo-tolerance, we will turn focus our lessons learned and investigate the allo-aggressive responses that are important in the treatment of cancer both in animal and clinical models
Moffatt-Bruce SThe immunobiology of photodynamic therapy: the potential for therapeutic intervention in lung cancer.J Natl Compr Canc Netw 10 Suppl 2 S27-30 10/1/2012
Shah Z, Kampfrath T, Deiuliis JA, Zhong J, Pineda C, Ying Z, Xu X, Lu B, Moffatt-Bruce S, Durairaj R, Sun Q, Mihai G, Maiseyeu A, Rajagopalan SLong-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis.Circulation 124(21) 2338-49 11/22/2011
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