Susan Moffatt-Bruce D MD

Susan Moffatt-Bruce D MD
Assoc ProfessorCollege of Medicinemoffatt-bruce.1@osu.edu
130 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-7081Fax:
  • Non-Member

General Research Interest

T cell immunology. The interaction of macrophages and T cells in lung cancer model.

Research Description

Our laboratory is interested in the role of T cells in the treatment of lung cancer. In particular, we are interested in investigating the role of T cells in patients that have both early and late lung cancer and received therapy in the form of photodynamic therapy.  We use both a lung cancer model as well as human samples (07115) and are currently investigating the role of T regulatory cells in these patient that receive the therapy and will follow their survival.  Additional studies will include investigating the role of macrophages in presenting antigen to the CD4 T cells and their response with and without treatment in patients with distinct stages of disease

Transinstitutional Work

This work is a collaborative effort between the Divisions of Transplantation, Cardiothoracic Surgery and Surgical Oncology.  As such, we plan on using the expertise gained in understanding the role of T cell biology in immune responses under varying treatment regimens.  Whilst in transplantation we are interested in allo-tolerance, we will turn focus our lessons learned and investigate the allo-aggressive responses that are important in the treatment of cancer both in animal and clinical models

Current Publications

  • Moffatt-Bruce S, Leon ME, Roth RMetastatic squamous cell carcinoma of the anus to the lung confirmed with allelotyping.Case Rep Pathol 2014 608521 1/1/2014
  • Mitchell JD, Schmitz DS, Grondin SC, Ikonomidis JS, Bakaeen FG, Merritt RE, Meyer DM, Moffatt-Bruce SD, Reece TB, Wood DE, Smith MAChoosing wisely: cardiothoracic surgeons partnering with patients to make good health care decisions.Ann Thorac Surg 95 1130-5 3/1/2013
  • Stawicki SP, Moffatt-Bruce SD, Ahmed HM, Anderson HL 3rd, Balija TM, Bernescu I, Chan L, Chowayou L, Cipolla J, Coyle SM, Gracias VH, Gunter OL, Marchigiani R, Martin ND, Patel J, Seamon MJ, Vagedes E, Ellison EC, Steinberg SM, Cook CHRetained surgical items: a problem yet to be solved.J Am Coll Surg 216 15-22 1/1/2013
  • Moffatt-Bruce SD, Ellison EC, Anderson HL 3rd, Steinberg SM, Stawicki SP, OPUS 12 Foundation, Inc. Multi-Center Trials Group, Chan L, Balija TM, Bernescu I, Cipolla J, Marchigiani R, Seamon MJ, Cook CHIntravascular retained surgical items: a multicenter study of risk factors.J Surg Res 178 519-23 11/1/2012
  • Gonsenhauser I, Beal E, Shihadeh F, Mekhjian HS, Moffatt-Bruce SDDevelopment and assessment of quality improvement education for medical students at The Ohio State University Medical Center.J Healthc Qual 34 36-42 11/1/2012
  • Moffatt-Bruce SD, Funai EF, Nash M, Gabbe SGPatient safety strategies: are we on the same team?Obstet Gynecol 120 743-5 10/1/2012
  • Moffatt-Bruce SThe immunobiology of photodynamic therapy: the potential for therapeutic intervention in lung cancer.J Natl Compr Canc Netw 10 Suppl 2 S27-30 10/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu