Susan D Moffatt-Bruce MD

Susan D Moffatt-Bruce MD
Assoc ProfessorCollege of Medicinemoffatt-bruce.1@osu.edu
130 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-7081Fax:
  • Innate Immunity

General Research Interest

T cell immunology. The interaction of macrophages and T cells in lung cancer model.

Research Description

Our laboratory is interested in the role of T cells in the treatment of lung cancer. In particular, we are interested in investigating the role of T cells in patients that have both early and late lung cancer and received therapy in the form of photodynamic therapy.  We use both a lung cancer model as well as human samples (07115) and are currently investigating the role of T regulatory cells in these patient that receive the therapy and will follow their survival.  Additional studies will include investigating the role of macrophages in presenting antigen to the CD4 T cells and their response with and without treatment in patients with distinct stages of disease

Transinstitutional Work

This work is a collaborative effort between the Divisions of Transplantation, Cardiothoracic Surgery and Surgical Oncology.  As such, we plan on using the expertise gained in understanding the role of T cell biology in immune responses under varying treatment regimens.  Whilst in transplantation we are interested in allo-tolerance, we will turn focus our lessons learned and investigate the allo-aggressive responses that are important in the treatment of cancer both in animal and clinical models

Current Publications

  • Leon MEMetastatic squamous cell carcinoma of the anus to the lung confirmed with allelotyping.Case Rep Pathol 2014 608521 1/1/2014
  • Moffatt-Bruce SThe immunobiology of photodynamic therapy: the potential for therapeutic intervention in lung cancer.J Natl Compr Canc Netw 10 Suppl 2 S27-30 10/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu