Tim Eubank D PhD

Tim Eubank D PhD
Asst ProfessorCollege of Medicineeubank.5@osu.edu
201 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
Phone:614-292-9958Fax: (614) 688-4662
  • Translational Therapeutics

General Research Interest

Mechanisms of breast cancer growth and metastases; angiogenesis; malignant melanoma; tumor-associated macrophages; tumor microenvironment

Research Description

Dr. Eubank's major focus is angiogenesis and the tumor microenvironment in breast cancer, specifcially, the pro- and anti-angiogenic affects of tumor-associated macrophages in solid tumors. I received the K99/R00 Pathway to Independence Award in 2008 to pursue our treatment strategy using Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) on breast cancer in mice. This paradigm involves the ability of GM-CSF to induce mononuclear phagocytes to produce large concentrations of the soluble form of the VEGF receptor-1 (sVEGFR-1). Overexpression of sVEGFR-1 sequesters VEGF bioavailability from nearby blood vessels. We have shown that GM-CSF treatment in the mouse PyMT breast cancer model slows tumor growth, reduces angiogenesis and tumor oxygen concentrations increasing tumor cell necrosis, minimizes tumor metastases to the lung, and initiates a transition of userped M2 tumor macrophages back to the M1 phenotype. We are currently utilizing human tumor cell lines in immunodeficient mice and hope these results can translate to human tumors. Another focus of an R21 with Valery Khramtsov involves the development of novel pH sensitive nanoprobes as less-invasive diagnostic tool for patients with breast cancer.

Transinstitutional Work

I have a collabroation with the Ron Glaser and John Sheridan (Institute of Behavioral Medicine) investigating the effects of different forms of stress on malignant melanoma in mice. Further, I have a collaboration with Avner Friedman (Department of Mathematics) taking a mathematical approach in evaluating our GM-CSF treatment paradigm for breast cancer.

Current Publications

  • Eubank TDA sympathetic role for the pancreas in tumor progression?Brain Behav Immun 40 38-9 8/1/2014
  • Samouilov A, Efimova OV, Bobko AA, Sun Z, Petryakov S, Eubank TD, Trofimov DG, Kirilyuk IA, Grigor'ev IA, Takahashi W, Zweier JL, Khramtsov VVIn vivo proton-electron double-resonance imaging of extracellular tumor pH using an advanced nitroxide probe.Anal Chem 86 1045-52 1/21/2014
  • Forget MA, Voorhees JL, Cole SL, Dakhlallah D, Patterson IL, Gross AC, Moldovan L, Mo X, Evans R, Marsh CB, Eubank TDMacrophage Colony-Stimulating Factor Augments Tie2-Expressing Monocyte Differentiation, Angiogenic Function, and Recruitment in a Mouse Model of Breast Cancer.PLoS One 9 e98623 1/1/2014
  • Sherwani SI, Aldana C, Usmani S, Adin C, Kotha S, Khan M, Eubank T, Scherer PE, Parinandi N, Magalang UJIntermittent hypoxia exacerbates pancreatic β-cell dysfunction in A mouse model of diabetes mellitus.Sleep 36 1849-58 12/1/2013
  • Justiniano SE, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda JM, Mo X, Cheney C, Hertlein E, Eubank TD, Marsh C, Muthusamy N, Butchar JP, Byrd JC, Tridandapani SFcγ receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.J Biol Chem 288 26800-9 9/13/2013
  • Mackos AR, Eubank TD, Parry NM, Bailey MTProbiotic Lactobacillus reuteri attenuates the stressor-enhanced severity of Citrobacter rodentium infection.Infect Immun 81 3253-63 9/1/2013
  • Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu BPeri-implant versus periodontal wound healing.J Clin Periodontol 40 816-24 8/1/2013
  • Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GB, Mace TA, Ameen ZPancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.Cancer Res 73 3007-18 5/15/2013
  • Dhimitruka I, Bobko AA, Eubank TD, Komarov DA, Khramtsov VVPhosphonated trityl probes for concurrent in vivo tissue oxygen and pH monitoring using electron paramagnetic resonance-based techniques.J Am Chem Soc 135 5904-10 4/17/2013
  • Piper MG, Marsh CB, Ismail N, Wang Y, Dakhlallah D, Moldovan L, Agarwal K, Batte K, Shah P, Wisler J, Eubank TD, Tridandapani S, Paulaitis MEMacrophage microvesicles induce macrophage differentiation and miR-223 transfer.Blood 121 984-95 2/7/2013
  • Yang EV, Eubank TDThe impact of adrenergic signaling in skin cancer progression: possible repurposing of β-blockers for treatment of skin cancer.Cancer Biomark 13 155-60 1/1/2013
  • Voorhees JL, Powell ND, Moldovan L, Mo X, Eubank TD, Marsh CBChronic restraint stress upregulates erythropoiesis through glucocorticoid stimulation.PLoS One 8 e77935 1/1/2013
  • Voorhees JL, Tarr AJ, Wohleb ES, Godbout JP, Mo X, Sheridan JF, Eubank TD, Marsh CBProlonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.PLoS One 8 e58488 1/1/2013
  • Chen D, Roda JM, Marsh CB, Eubank TD, Friedman AHypoxia inducible factors-mediated inhibition of cancer by GM-CSF: a mathematical model.Bull Math Biol 74 2752-77 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu