Jonathan P Butchar PhD
Jonathan P Butchar PhD
415 Davis Heart & Lung Inst 473 W 12th Avenue Columbus OH 43210
General Research InterestMonocyte / macrophage immune responses within the context of antibody therapy.
Research DescriptionMonocytes / macrophages can engulf or even directly kill antibody-coated tumor cells, and this is mediated largely through Fc-gamma receptors. These cells can also respond to pathogens such as bacteria or viruses by activation of Toll-like receptors. Such Toll-like receptor activation has been shown to enhance Fc-gamma receptor function. My work involves bringing pathogenesis and tumor immunotherapy together by studying the interactions between Fc-gamma receptor and Toll-like receptor signaling. The ultimate goal is to help improve the efficacy of antibody therapy.
Transinstitutional WorkAs the focus of my work is on antibody therapy, I actively collaborate with Dr. John Byrd and Dr. William Carson at the OSU CCC. For basic research on Toll-like receptor signaling I have been collaborating with Dr. Amal Amer at the OSU CMIB and with Dr. Thirumala-Devi Kanneganti of St. Jude Children’s Research Hospital (Memphis, TN).
Shah P, Fatehchand K, Patel H, Fang H, Justiniano SE, Mo X, Jarjoura D, Tridandapani S, Butchar JPToll-like receptor 2 ligands regulate monocyte Fcγ receptor expression and function.J Biol Chem 288(17) 12345-52 4/26/2013
Rafiq S, Butchar JP, Cheney C, Mo X, Trotta R, Caligiuri M, Jarjoura D, Tridandapani S, Muthusamy N, Byrd JCComparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties.J Immunol 190(6) 2702-11 3/15/2013
Trotta R, Chen L, Ciarlariello D, Josyula S, Mao C, Costinean S, Yu L, Butchar JP, Tridandapani S, Croce CM, Caligiuri MAmiR-155 regulates IFN-γ production in natural killer cells.Blood 119(15) 3478-85 4/12/2012
Cremer TJ, Fatehchand K, Shah P, Gillette D, Patel H, Marsh RL, Besecker BY, Rajaram MV, Cormet-Boyaka E, Kanneganti TD, Schlesinger LS, Butchar JP, Tridandapani SMiR-155 induction by microbes/microbial ligands requires NF-κB-dependent de novo protein synthesis.Front Cell Infect Microbiol 2 73 1/1/2012
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