L. James Lee PhD

L. James Lee PhD
ProfessorCollege of Engineeringlee.31@osu.edu
1012 Smith Laboratory 174 W 18th Avenue Columbus Ohio 43210
Phone:614-292-2408Fax: (614) 292-3769
  • Leukemia Research

Research Description

Dr. Lee's research interests are in polymer engineering of nanomaterials and nanotechnology with applications to Bio-Micro-Electro-Mechanical Systems (BioMEMS). MEMS emerged from IC manufacturing and is gaining applications in biomedical and optical communications fields. Major applications are cancer detection and treatment, and cell reprogramming for regenerative medicine.

Current Publications

  • Wang X, He H, Lu Y, Ren W, Teng KY, Chiang CL, Yang Z, Yu B, Hsu S, Jacob ST, Ghoshal K, Lee LJIndole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog.Biochim Biophys Acta 1853 244-53 1/1/2015
  • Chang L, Howdyshell M, Liao WC, Chiang CL, Gallego-Perez D, Yang Z, Lu W, Byrd JC, Muthusamy N, Lee LJ, Sooryakumar RMagnetic Tweezers-Based 3D Microchannel Electroporation for High-Throughput Gene Transfection in Living Cells.Small in press 12/2/2014
  • Wang X, Huang X, Yang Z, Gallego-Perez D, Ma J, Zhao X, Xie J, Nakano I, Lee LJTargeted Delivery of Tumor Suppressor MicroRNA-1 by Transferrin-Conjugated Lipopolyplex Nanoparticles to Patient-Derived Glioblastoma Stem Cells.Curr Pharm Biotechnol in press 10/30/2014
  • Zhou X, Wang J, Wu J, Yang X, Yung BC, Lee LJ, Lee RJPreparation and evaluation of a novel liposomal formulation of cisplatin.Eur J Pharm Sci in press 10/16/2014
  • Mao Y, Wang J, Zhao Y, Yan R, Li H, Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N, Phelps MAQuantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry.J Pharm Biomed Anal 98 160-5 9/1/2014
  • Yang X, Wang X, Yung BC, Lee LJ, Lee RJ, Teng L, Yang Z, Yu B, Zhu J, Huang X, Xie J, Xu SA microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia.Nanoscale 6 9742-51 8/21/2014
  • Chen CS, Lee RJ, Byrd JC, Lee LJ, Muthusamy N, Mani R, Mao Y, Frissora FW, Chiang CL, Wang J, Zhao Y, Wu Y, Yu B, Yan R, Mo X, Yu L, Flynn J, Jones J, Andritsos L, Baskar S, Rader C, Phelps MATumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B cell cytotoxicity in chronic lymphocytic leukemia.Leukemia in press 6/20/2014
  • Yu B, Wang X, Zhou C, Teng L, Ren W, Yang Z, Shih CH, Wang T, Lee RJ, Tang S, Lee LJInsight into Mechanisms of Cellular Uptake of Lipid Nanoparticles and Intracellular Release of Small RNAs.Pharm Res in press 4/17/2014
  • Terp MC, Wu Y, Yu B, Kwak KJ, Lee LJMicrowell array guided assembly of lipoplex nanoparticles containing siRNA.Langmuir 30 2873-8 3/18/2014
  • Gao K, Li L, He L, Hinkle K, Wu Y, Ma J, Chang L, Zhao X, Perez DG, Eckardt S, McLaughlin J, Liu B, Farson DF, Lee LJDesign of a microchannel-nanochannel-microchannel array based nanoelectroporation system for precise gene transfection.Small 10 1015-23 3/12/2014
  • Mao Y, Wang J, Zhao Y, Wu Y, Kwak KJ, Chen CS, Byrd JC, Lee RJ, Phelps MA, Lee LJ, Muthusamy NA novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery.Nanomedicine 10 393-400 2/1/2014
  • Binjawadagi B, Dwivedi V, Manickam C, Ouyang K, Wu Y, Lee LJ, Torrelles JB, Renukaradhya GJAdjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs.Int J Nanomedicine 9 679-94 1/1/2014
  • Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJEnhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.J Control Release 172 690-8 12/28/2013
  • Lee LJ, Wu Y, Kwak KJ, Agarwal K, Marras A, Wang C, Mao Y, Huang X, Ma J, Yu B, Lee R, Vachani A, Marcucci G, Byrd JC, Muthusamy N, Otterson G, Huang K, Castro CE, Paulaitis M, Nana-Sinkam SPDetection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons.Anal Chem 85 11265-74 12/3/2013
  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.Nanomedicine 9 1169-80 11/1/2013
  • Huang W, Yu J, Kwak KJ, Gallego-Perez D, Liao WC, Yang H, Ouyang X, Li L, Lu W, Lafyatis GP, Lee LJAtomic carbide bonding leading to superior graphene networks.Adv Mater 25 4668-72 9/6/2013
  • Byrd JC, Lee LJ, Muthusamy N, Yu B, Mao Y, Yuan Y, Yue C, Wang X, Mo X, Jarjoura D, Paulaitis ME, Lee RJTargeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells.Biomaterials 34 6185-93 8/1/2013
  • Wu Y, Terp MC, Kwak KJ, Gallego-Perez D, Nana-Sinkam SP, Lee LJSurface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays.Small 9 2358-67 7/8/2013
  • Zhang M, Zhou X, Wang B, Yung BC, Lee LJ, Ghoshal K, Lee RJLactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma.J Control Release 168 251-61 6/28/2013
  • Zhou C, Zhang Y, Yu B, Phelps MA, Lee LJ, Lee RJComparative cellular pharmacokinetics and pharmacodynamics of siRNA delivery by SPANosomes and by cationic liposomes.Nanomedicine 9 504-13 5/1/2013
  • Huang X, Schwind S, Yu B, Santhanam R, Wang H, Hoellerbauer P, Mims A, Klisovic R, Walker AR, Chan KK, Blum W, Perrotti D, Byrd JC, Bloomfield CD, Caligiuri MA, Lee RJ, Garzon R, Muthusamy N, Lee LJ, Marcucci GTargeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia.Clin Cancer Res 19 2355-67 5/1/2013
  • He H, Luedke E, Zhang X, Yu B, Schmitt A, McClarren B, Grignol V, Carson WE 3rd, Lee LJA naonoporous cell-therapy device with controllable biodegradation for long-term drug release.J Control Release 165 226-33 2/10/2013
  • Fei Z, Wu Y, Sharma S, Gallego-Perez D, Higuita-Castro N, Hansford D, Lannutti JJ, Lee LJGene delivery to cultured embryonic stem cells using nanofiber-based sandwich electroporation.Anal Chem 85 1401-7 2/5/2013
  • Mao Y, Triantafillou G, Hertlein E, Towns W, Stefanovski M, Mo X, Jarjoura D, Phelps M, Marcucci G, Lee LJ, Goldenberg DM, Lee RJ, Byrd JC, Muthusamy NMilatuzumab-conjugated liposomes as targeted dexamethasone carriers for therapeutic delivery in CD74+ B-cell malignancies.Clin Cancer Res 19 347-56 1/15/2013
  • Yu B, Mao Y, Bai LY, Herman SE, Wang X, Ramanunni A, Jin Y, Mo X, Cheney C, Chan KK, Jarjoura D, Marcucci G, Lee RJ, Byrd JC, Lee LJ, Muthusamy NTargeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.Blood 121 136-47 1/3/2013
  • Alachkar H, Maharry K, Nicolet D, Mrózek K, Walker A, Eiring AM, Whitman SP, Becker H, Perrotti D, Wu LC, Zhao X, Fehniger TA, Vij R, Byrd JC, Blum W, Lee LJ, Caligiuri MA, Bloomfield CD, Garzon R, Marcucci G, Hickey CJ, Schwind S, Radomska HS, Dorrance AM, Santhanam R, Mishra A, Wu YZLenalidomide-mediated enhanced translation of C/EBPα-p30 protein up-regulates expression of the antileukemic microRNA-181a in acute myeloid leukemia.Blood 121 159-69 1/3/2013
  • Wang S, Lee LJMicro-/nanofluidics based cell electroporation.Biomicrofluidics 7 11301 1/1/2013
  • Wu Y, Crawford M, Mao Y, Lee RJ, Davis IC, Elton TS, Lee LJ, Nana-Sinkam SPTherapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.Mol Ther Nucleic Acids 2 e84 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu