Marshall V Williams, Jr. PhD


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Marshall V Williams, Jr. PhD
ProfessorCollege of Medicinewilliams.70@osu.edu
353 Behavioral Med Research, Inst 460 Medical Center Drive Columbus Ohio 43210
Phone:614-293-6175Fax: 614-366-2097
  • Non-Member

General Research Interest

Dr. William's research is focused on the role(s) that a protein, deoxyuridine triphosphate nucleotidohydrolases (dUTPase) encoded by the human herpesviruses and some retroviruses has in the pathophysiology of disease.

Research Description

Several viruses including Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV8) encode for a deoxyuridine triphosphate nucleotidohydrolases (dUTPase). We have demonstrated that these herpesvirus encoded dUTPase as well as a human retrovirus encoded dUTPase possess novel properties, independent of their enzymatic activities, that alter the immune response (innate and adaptive). Our studies are focused on how the virus encoded dUTPases alter the tumor microenvironment promoting the growth/survival of tumor cells latently infected by these viruses.

Current Publications

  • Ariza ME, Williams MV, Wong HKTargeting IL-17 in psoriasis: from cutaneous immunobiology to clinical application.Clin Immunol 146 131-9 2/1/2013
  • Ariza ME, Rivailler P, Glaser R, Chen M, Williams MVEpstein-Barr virus encoded dUTPase containing exosomes modulate innate and adaptive immune responses in human dendritic cells and peripheral blood mononuclear cells.PLoS One 8 e69827 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu