Michael Oglesbee J DVM, PhD


Michael Oglesbee J DVM, PhD
ChairCollege of Veterinary Medicineoglesbee.1@osu.edu
0207 Goss Laboratory 1925 Coffey Road Columbus Ohio 43210
  • Administrative
  • Translational Therapeutics

General Research Interest

virus-heat shock protein interaction and the impact on neurovirulence 

Research Description

Cellular heat shock proteins (HSPs) are known for their support of viral gene expression, and for influencing innate and adaptive immune responses, yet nothing is known about how virus-HSP interaction may influence viral virulence. Our laboratory uses the mouse model of measles virus (MeV) neuronal infection in brain to establish the in vivo significance of this virus-host interaction. Using transgenic mice that selectively overexpress the major inducible 70 kDa HSP (hsp70) in neurons, we have shown that hsp70-dependent stimulation of MeV transcription causes enhanced neurovirulence in an immune compromised host, yet supports viral clearance in an immune competent host. Clearance requires the viral transcriptional response to hsp70, and is attributed to both increased innate and adaptive antiviral immune responses. Ongoing efforts are designed to establish mechanisms by which hsp70 may modulate these protective immune responses, either directly as a consequence of extracellular hsp70 release from infected cells, or indirectly as a consequence of hsp70-dependent changes in viral gene expression and/or cytopathic effect.

Transinstitutional Work

Our analysis of the role of hsp70 in modulating host immune responses in the central nervous system is the basis for collaboration with other investigators in the neurosciences. Spinal cord trauma induces an inflammatory response that may be either host protective or detrimental, and it is possible that hsp70 modulates these responses. This is the basis for collaboration with laboratories in the Center for Brain and Spinal Cord Repair, The Ohio State University Medical Center. The study of viral neurovirulence is also relevant to studies of viral oncolytic therapy of brain tumors, with MeV being an established oncolytic agent, and potential barriers to oncolytic therapy being innate and adaptive antiviral immune responses. This interest is the basis for collaboration with faculty in the department of Neurological Surgery, The Ohio State University Medical Center, where focus is placed upon viral oncolytic therapy of human gliomas. More broad trans-institutional involves collaborative research with investigators at the University of Marseille (France), where protein chemists with expertise in intrinsically disordered domains are supporting our ongoing to attempts to identify the structural basis for hsp70-mediated stimulation of viral gene expression.

Current Publications

  • Chiocca E Antonio, Price RL, Hollon T, Alvarez-Breackenridge C, Fernandez S, Oglesbee Mike, Cook C, Lawler S, Kwon Chang-HyukCytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Neuro Oncol 16 Suppl 3 iii8 7/1/2014
  • Lovett MC, Coates JR, Shu Y, Oglesbee MJ, Fenner W, Moore SAQuantitative assessment of hsp70, IL-1β and TNF-α in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy.Vet J 200 312-7 5/1/2014
  • Ma Y, Duan Y, Wei Y, Liang X, Niewiesk S, Oglesbee M, Li JHeat shock protein 70 enhances mucosal immunity against human norovirus when coexpressed from a vesicular stomatitis virus vector.J Virol 88 5122-37 5/1/2014
  • Bolon B, Oglesbee MJ, Clinton SK, Kulp SK, Chen CS, Perle KM, Berman-Booty LD, Thomas-Ahner JMExtra-prostatic Transgene-associated Neoplastic Lesions in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.Toxicol Pathol in press 4/17/2014
  • Ma Y, Wei Y, Zhang X, Zhang Y, Cai H, Zhu Y, Shilo K, Oglesbee M, Krakowka S, Whelan SP, Li JmRNA cap methylation influences pathogenesis of vesicular stomatitis virus in vivo.J Virol 88 2913-26 3/1/2014
  • Kim MY, Ma Y, Zhang Y, Li J, Shu Y, Oglesbee Mhsp70-dependent antiviral immunity against cytopathic neuronal infection by vesicular stomatitis virus.J Virol 87 10668-78 10/1/2013
  • Oglesbee MJ, LaBranche TInside-out: extracellular roles for heat shock proteins.Vet Pathol 50 921-4 9/1/2013
  • Price RL, Song J, Bingmer K, Kim TH, Yi JY, Nowicki MO, Mo X, Hollon T, Kwon CH, Murnan E, Alvarez-Breckenridge C, Fernandez S, Kaur B, Rivera A, Oglesbee M, Cook C, Chiocca EACytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Cancer Res 73 3441-50 6/1/2013
  • Kim MY, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, Longhi S, Girod S, Niewiesk S, Oglesbee Mhsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.J Virol 87 998-1009 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu