Susanne Wells I PhD


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Susanne Wells I PhD
Asst ProfessorCollege of Medicine - UCSusanne.Wells@cchmc.org
TCHRF 6501B, MLC 7013 3333 Burnet Avenue Cincinnati OH 45229
Phone:(513) 636-5986Fax: (513) 636-3768
  • Translational Therapeutics

Research Description

Dr. Wells' research goal is to advance the understanding of both HPV-related and -unrelated SCC development, and to develop new approaches to the diagnosis and treatment of HPV as a major cause of cancer worldwide. Two major areas of investigation in the laboratory focus on: (1) Mechanisms by which the HPV oncogenes subvert the host cell machinery to promote abnormal cell growth and cancer and (2) The role of specific cellular HPV targets in viral replication and cellular transformation. Model systems utilized include primary human and murine cells and tumors, three-dimensional organotypic epithelial rafts and mouse models of cancer.

Current Publications

  • Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SIHigh-Risk Human Papillomavirus E6 Protein Promotes Reprogramming of Fanconi Anemia Patient Cells through Repression of p53 but Does Not Allow for Sustained Growth of Induced Pluripotent Stem Cells.J Virol 88 11315-26 10/1/2014
  • Privette Vinnedge LM, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE, Wells SIThe DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers.Oncogene in press 6/23/2014
  • Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI, Adams AKDEK promotes HPV-positive and -negative head and neck cancer cell proliferation.Oncogene in press 1 3/10/2014
  • Adams AK, Wise-Draper TM, Wells SIHuman papillomavirus induced transformation in cervical and head and neck cancers.Cancers (Basel) 6 1793-820 1/1/2014
  • Bahassi el M, Li YQ, Wise-Draper TM, Deng L, Wang J, Darnell CN, Wilson KM, Wells SI, Stambrook PJ, Rixe OA patient-derived somatic mutation in the epidermal growth factor receptor ligand-binding domain confers increased sensitivity to cetuximab in head and neck cancer.Eur J Cancer 49 2345-55 7/1/2013
  • Romick-Rosendale LE, Lui VW, Grandis JR, Wells SIThe Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.Mutat Res 743-744 78-88 3/1/2013
  • Yablonska S, Hoskins EE, Wells SI, Khan SAIdentification of miRNAs Dysregulated in Human Foreskin Keratinocytes (HFKs) Expressing the Human Papillomavirus (HPV) Type 16 E6 and E7 Oncoproteins.Microrna 2 2-13 1/1/2013
  • Privette Vinnedge LM, Kappes F, Nassar N, Wells SIStacking the DEK: from chromatin topology to cancer stem cells.Cell Cycle 12 51-66 1/1/2013
  • Kim KJ, Godarova A, Seedle K, Kim MH, Ince TA, Wells SI, Driscoll JJ, Godar SRb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner.PLoS One 8 e80590 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu