Stefan Niewiesk DVM, PhD


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Stefan Niewiesk DVM, PhD
ProfessorCollege of Veterinary Medicineniewiesk.1@osu.edu
0460 Veterinary Medicine Acad Bldg 1900 Coffey Road Columbus Ohio 43210
Phone:614-688-3605Fax: (614) 292-6473
  • Leukemia Research

General Research Interest

Paramyxovirus pathogenesis, vaccination (in the presence of maternal antibodies), T cell tumors, adult T cell leukemia, oncolytic therapy 

Research Description

One of the interests of the Niewiesk laboratory is the use of measles vaccine virus as oncolytic therapy to cure T cell leukemias. We use the mouse model of adult T cell leukemia to study the interaction between tumor cells, microenviroment and virus. One aspect of this research is how to use genetically improved viruses to combat leukemia and how to combine viral oncolytic therapy with other conventional or experimental therapies.

Transinstitutional Work

Participation in Viral Oncology program of the CCC at The Oio State University and the program project grant "Retrovirus Models of Lymphocyte Transformation and Disease" with participants from Washington University in St. Louis. Collaboration on vaccination and antivirals with Emory University, Cornell University and various companies.

Current Publications

  • Zhang Y, Wei Y, Zhang X, Cai H, Niewiesk S, Li JRational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase.J Virol 88 11411-29 10/1/2014
  • M Parrula MC, Fernandez SA, Landes K, Huey D, Lairmore M, Niewiesk SSuccess of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.Virus Res 189 206-13 8/30/2014
  • Ma Y, Duan Y, Wei Y, Liang X, Niewiesk S, Oglesbee M, Li JHeat shock protein 70 enhances mucosal immunity against human norovirus when coexpressed from a vesicular stomatitis virus vector.J Virol 88 5122-37 5/1/2014
  • Wei Y, Zhang Y, Cai H, Mirza AM, Iorio RM, Peeples ME, Niewiesk S, Li JRoles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis.J Virol 88 4338-52 4/1/2014
  • Kim D, Niewiesk SSynergistic induction of interferon α through TLR-3 and TLR-9 agonists stimulates immune responses against measles virus in neonatal cotton rats.Vaccine 32 265-70 1/3/2014
  • Schneider-Schaulies J, Niewiesk S, Carsillo T, Huey D, Levinsky A, Obojes KCotton Rat (Sigmodon hispidus) Signaling Lymphocyte Activation Molecule (CD150) Is an Entry Receptor for Measles Virus.PLoS One 9 e110120 1/1/2014
  • Green MG, Huey D, Niewiesk SThe cotton rat (Sigmodon hispidus) as an animal model for respiratory tract infections with human pathogens.Lab Anim (NY) 42 170-6 5/1/2013
  • Kim D, Niewiesk SSynergistic induction of interferon α through TLR-3 and TLR-9 agonists identifies CD21 as interferon α receptor for the B cell response.PLoS Pathog 9 e1003233 3/1/2013
  • Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona AInteraction between the hemagglutinin-neuraminidase and fusion glycoproteins of human parainfluenza virus type III regulates viral growth in vivo.MBio 4 e00803-13 1/1/2013
  • Kim MY, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, Longhi S, Girod S, Niewiesk S, Oglesbee Mhsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.J Virol 87 998-1009 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu