Stefan Niewiesk DVM, PhD


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Stefan Niewiesk DVM, PhD
ProfessorCollege of Veterinary Medniewiesk.1@osu.edu
0460 Veterinary Medicine Acad Bldg 1900 Coffey Road Columbus Ohio 43210
Phone:614-688-3605Fax: 614-292-6473
  • Viral Oncology

General Research Interest

Paramyxovirus pathogenesis, vaccination (in the presence of maternal antibodies), T cell tumors, adult T cell leukemia, oncolytic therapy 

Research Description

One of the interests of the Niewiesk laboratory is the use of measles vaccine virus as oncolytic therapy to cure T cell leukemias. We use the mouse model of adult T cell leukemia to study the interaction between tumor cells, microenviroment and virus. One aspect of this research is how to use genetically improved viruses to combat leukemia and how to combine viral oncolytic therapy with other conventional or experimental therapies.

Transinstitutional Work

Participation in Viral Oncology program of the CCC at The Oio State University and the program project grant "Retrovirus Models of Lymphocyte Transformation and Disease" with participants from Washington University in St. Louis. Collaboration on vaccination and antivirals with Emory University, Cornell University and various companies.

Current Publications

  • Niewiesk SSynergistic induction of interferon a through TLR-3 and TLR-9 agonists stimulates immune responses against measles virus in neonatal cotton rats.Vaccine 32 265-70 1/3/2014
  • Yin H, Kannian P, Dissinger N, Haines R, Niewiesk S, Green PLHuman T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo.J Virol 86(16) 8412-21 8/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu