Balveen Kaur PhD


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Balveen Kaur PhD
ProfessorCollege of Medicinekaur.11@osu.edu
385D Wiseman Hall 400 W 12th Avenue Columbus Ohio 43210
Phone:614-292-3984Fax: (614) 688-4882
  • Translational Therapeutics

Research Description

Dr. Kaur’s laboratory is focused on the development of oncolytic viral therapies. Interests include immunomodulation, antiangiogenic strategies, and tumor microenvironment.

Current Publications

  • Kim TH, Song J, Kim SH, Parikh AK, Mo X, Palanichamy K, Kaur B, Yu J, Yoon SO, Nakano I, Kwon CHPiperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.Neuro Oncol 16 1354-64 10/1/2014
  • Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, Chiocca N, Amankulor N, Cohen JB, Glorioso JC, Grandi PUse of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV.Mol Ther in press 9/9/2014
  • Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, Caligiuri MA, Tridandapani S, Kaur BRole of Cysteine-rich 61 Protein (CCN1) in Macrophage-mediated Oncolytic Herpes Simplex Virus Clearance.Mol Ther 22 1678-87 9/1/2014
  • Kellough DA, Ecsedy JA, Kaur B, Lehman NL, Brocklyn JR, Wojton J, Meisen WHAurora-A Inhibition Offers a Novel Therapy Effective against Intracranial Glioblastoma.Cancer Res in press 8/8/2014
  • Wojton J, Meisen WH, Jacob NK, Thorne AH, Hardcastle J, Denton N, Chu Z, Dmitrieva N, Marsh R, Van Meir EG, Kwon CH, Chakravarti A, Qi X, Kaur BSapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma.Oncotarget in press 7/17/2014
  • Yoo JY, Hurwitz BS, Bolyard C, Yu JG, Zhang J, Selvendiran K, Rath KS, He S, Bailey Z, Eaves D, Cripe TP, Parris DS, Caligiuri MA, Yu J, Old M, Kaur BBortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects.Clin Cancer Res 20 3787-98 7/15/2014
  • Kaur Balveen, Meisen WH, Hardcastle J, Wojton J, Wohleb E, Alvarez-Breckenridge C, Pow-Anpongkul P, Godbout J, Kaur BVstat120 reduces the innate inflammatory response to infection and enhances oncolytic viral therapy for glioblastoma.Neuro Oncol 16 Suppl 3 iii42 7/1/2014
  • Guo Deliang, Geng F, Aggarwal R, Liu J, Yoo JY, Guo Q, Guo JY, Hurwitz B, Ru P, Cheng C, Joshi K, Ichiro Nakano, Kaur Balveen, Chakravarti ArnabInterplay of lipid droplets and autophagy regulates glioblastoma survival.Neuro Oncol 16 Suppl 3 iii9 7/1/2014
  • Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Yan F, Alinari L, Lustberg ME, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RAGenetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.Cancer Res 74 1752-65 3/15/2014
  • Chu Z, LaSance K, Blanco V, Kwon CH, Kaur B, Frederick M, Thornton S, Lemen L, Qi XIn Vivo Optical Imaging of Brain Tumors and Arthritis Using Fluorescent SapC-DOPS Nanovesicles.J Vis Exp 1/1/2014
  • Kim Y, Lee HG, Dmitrieva N, Kim J, Kaur B, Friedman AChoindroitinase ABC I-Mediated Enhancement of Oncolytic Virus Spread and Anti Tumor Efficacy: A Mathematical Model.PLoS One 9 e102499 1/1/2014
  • Onishi M, Kurozumi K, Ichikawa T, Michiue H, Fujii K, Ishida J, Shimazu Y, Chiocca EA, Kaur B, Date IGene expression profiling of the anti-glioma effect of Cilengitide.Springerplus 2 160 12/1/2013
  • Okemoto K, Kasai K, Wagner B, Haseley A, Meisen H, Bolyard C, Mo X, Wehr A, Lehman A, Fernandez S, Kaur B, Chiocca EADNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas.Clin Cancer Res 19 5952-9 11/1/2013
  • Stephenson JR, Paavola KJ, Schaefer SA, Kaur B, Van Meir EG, Hall RABrain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density.J Biol Chem 288 22248-56 8/2/2013
  • Fujii K, Kurozumi K, Ichikawa T, Onishi M, Shimazu Y, Ishida J, Chiocca EA, Kaur B, Date IThe integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus.Cancer Gene Ther 20 437-44 8/1/2013
  • Wojton J, Chu Z, Mathsyaraja H, Meisen WH, Denton N, Kwon CH, Chow LM, Palascak M, Franco R, Bourdeau T, Thornton S, Ostrowski MC, Kaur B, Qi XSystemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma.Mol Ther 21 1517-25 8/1/2013
  • Price RL, Song J, Bingmer K, Kim TH, Yi JY, Nowicki MO, Mo X, Hollon T, Kwon CH, Murnan E, Alvarez-Breckenridge C, Fernandez S, Kaur B, Rivera A, Oglesbee M, Cook C, Chiocca EACytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Cancer Res 73 3441-50 6/1/2013
  • Currier MA, Eshun FK, Sholl A, Chernoguz A, Crawford K, Divanovic S, Boon L, Goins WF, Frischer JS, Collins MH, Leddon JL, Baird WH, Hendrickson BW, Brekken RA, Kaur B, Hildeman D, Cripe TP, Haseley A, Streby KA, Wang PYVEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells.Mol Ther 21 1014-23 5/1/2013
  • Meisen WH, Kaur BHow can we trick the immune system into overcoming the detrimental effects of oncolytic viral therapy to treat glioblastoma?Expert Rev Neurother 13 341-3 4/1/2013
  • Onishi M, Ichikawa T, Kurozumi K, Fujii K, Yoshida K, Inoue S, Michiue H, Chiocca EA, Kaur B, Date IBimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models.Neuropathology 33 162-74 4/1/2013
  • Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC, Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CS, Mazzacurati L, Yoo JYEffective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus.Mol Ther 21 561-9 3/1/2013
  • Kaur B, Balgir PP, Mittu B, Kumar B, Garg NBiomedical applications of fermenticin HV6b isolated from Lactobacillus fermentum HV6b MTCC10770.Biomed Res Int 2013 168438 1/1/2013
  • Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AAThymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.PLoS One 8 e72882 1/1/2013
  • Okemoto K, Wagner B, Meisen H, Haseley A, Kaur B, Chiocca EASTAT3 activation promotes oncolytic HSV1 replication in glioma cells.PLoS One 8 e71932 1/1/2013
  • Alvarez-Breckenridge CA, Yu J, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez SA, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EANK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.Nat Med 18 1827-34 12/1/2012
  • Gatson NN, Chiocca EA, Kaur BAnti-angiogenic gene therapy in the treatment of malignant gliomas.Neurosci Lett 527 62-70 10/11/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu