David Symer E MD, PhD


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David Symer E MD, PhD
Asst ProfessorCollege of Medicinesymer.2@osu.edu
440 Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-292-0885Fax: (614) 292-6108
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Symer studies mammalian retrotransposons, their epigenetic controls, and resulting functional variation. His research aims to understand some of the causes and consequences of changing epigenetic states upon the transposons, the genes and transcripts they affect, and genomic instability, with an emphasis on certain cancers. In particular, specific examples of transcriptional and phenotypic variation that are due to existing or de novo endogenous retrotransposon integrants and due to the epigenetic controls that regulate them are being identified and characterized.

Current Publications

  • Schliehe C, Flynn EK, Vilagos B, Richson U, Swaminathan S, Bosnjak B, Bauer L, Kandasamy RK, Griesshammer IM, Kosack L, Schmitz F, Litvak V, Sissons J, Lercher A, Bhattacharya A, Khamina K, Trivett AL, Tessarollo L, Mesteri I, Hladik A, Merkler D, Kubicek S, Knapp S, Epstein MM, Symer DE, Aderem A, Bergthaler AThe methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.Nat Immunol in press 11/24/2014
  • Li J, Kannan M, Trivett AL, Liao H, Wu X, Akagi K, Symer DEAn antisense promoter in mouse L1 retrotransposon open reading frame-1 initiates expression of diverse fusion transcripts and limits retrotransposition.Nucleic Acids Res 42 4546-62 4/1/2014
  • Akagi K, Li J, Broutian TR, Padilla-Nash H, Xiao W, Jiang B, Rocco JW, Teknos TN, Kumar B, Wangsa D, He D, Ried T, Symer DE, Gillison MLGenome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.Genome Res 24 185-99 2/1/2014
  • Golubeva Y, Symer DCollection and preparation of rodent embryonic samples for transcriptome study.Methods Mol Biol 1092 297-356 1/1/2014
  • He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang R, Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle ACorrection: Ultra-Rare Mutation in Long-Range Enhancer Predisposes to Thyroid Carcinoma with High Penetrance.PLoS One 8(9) 9/10/2013
  • He H, Bronisz A, Liyanarachchi S, Nagy R, Li W, Huang Y, Akagi K, Saji M, Kula D, Wojcicka A, Sebastian N, Wen B, Puch Z, Kalemba M, Stachlewska E, Czetwertynska M, Dlugosinska J, Dymecka K, Ploski R, Krawczyk M, Morrison PJ, Ringel MD, Kloos RT, Jazdzewski K, Symer DE, Vieland VJ, Ostrowski M, Jarząb B, de la Chapelle ASRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.J Clin Endocrinol Metab 98 E973-80 5/1/2013
  • Akagi K, Li J, Symer DEHow do mammalian transposons induce genetic variation? A conceptual framework: the age, structure, allele frequency, and genome context of transposable elements may define their wide-ranging biological impacts.Bioessays 35 397-407 4/1/2013
  • Hertlein E, Beckwith KA, Lozanski G, Chen TL, Towns WH, Johnson AJ, Lehman A, Ruppert AS, Bolon B, Andritsos L, Lozanski A, Rassenti L, Zhao W, Jarvinen TM, Senter L, Croce CM, Symer DE, de la Chapelle A, Heerema NA, Byrd JCCharacterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease.PLoS One 8 e76607 1/1/2013
  • Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle A, He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang RUltra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.PLoS One 8 e61920 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu