Jianhua Yu PhD


Jianhua Yu PhD
Asst ProfessorCollege of Medicineyu.265@osu.edu
816 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
  • Molecular Carcinogenesis and Chemoprevention

Research Description

Dr. Yu's research interests include Immuno-cellular therapy, blood and marrow transplantation, NK cell biology, gene regulation and cell signaling in immune response and malignant transformation

Current Publications

  • Kim TH, Song J, Kim SH, Parikh AK, Mo X, Palanichamy K, Kaur B, Yu J, Yoon SO, Nakano I, Kwon CHPiperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.Neuro Oncol 16 1354-64 10/1/2014
  • Caligiuri MA, Yu J, Deng Y, Chu J, Ren Y, Fan Z, Ji X, Mundy-Bosse B, Yuan S, Hughes T, Zhang J, Cheema B, Camardo AT, Xia Y, Wu LC, Wang LS, He X, Kinghorn AD, Li XThe Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling.J Immunol 193 9/15/2014
  • Rao W, Zhao S, Yu J, Lu X, Zynger DL, He XEnhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules.Biomaterials 35 7762-73 9/1/2014
  • Thorne AH, Meisen WH, Russell L, Yoo JY, Bolyard CM, Lathia JD, Rich J, Puduvalli VK, Mao H, Yu J, Caligiuri MA, Tridandapani S, Kaur BRole of Cysteine-rich 61 Protein (CCN1) in Macrophage-mediated Oncolytic Herpes Simplex Virus Clearance.Mol Ther 22 1678-87 9/1/2014
  • Chu J, He S, Deng Y, Zhang J, Peng Y, Hughes T, Yi L, Kwon CH, Wang QE, Devine SM, He X, Bai XF, Hofmeister CC, Yu JGenetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.Clin Cancer Res 20 3989-4000 8/1/2014
  • Yoo JY, Hurwitz BS, Bolyard C, Yu JG, Zhang J, Selvendiran K, Rath KS, He S, Bailey Z, Eaves D, Cripe TP, Parris DS, Caligiuri MA, Yu J, Old M, Kaur BBortezomib-induced unfolded protein response increases oncolytic HSV-1 replication resulting in synergistic antitumor effects.Clin Cancer Res 20 3787-98 7/15/2014
  • Hughes T, Briercheck EL, McClory S, Scoville SD, Keller K, Deng Y, Cole J, Harrison N, Mao C, Zhang J, Benson DM, Yu J, Caligiuri MA, Freud AG, Trotta RThe transcription Factor AHR prevents the differentiation of a stage 3 innate lymphoid cell subset to natural killer cells.Cell Rep 8 150-62 7/10/2014
  • Han C, Zhao R, Liu X, Srivastava A, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang QEDDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer.Mol Cancer Res 12 784-94 5/1/2014
  • Freud AG, Yu J, Caligiuri MAHuman natural killer cell development in secondary lymphoid tissues.Semin Immunol 26 132-7 4/1/2014
  • Devine SM, Zhang X, Caligiuri MA, Hofmeister CC, Yu J, Chu J, Deng Y, Benson DM, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He XCS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma.Leukemia 28 917-27 4/1/2014
  • He S, Chu J, Vasu S, Deng Y, Yuan S, Zhang J, Fan Z, Hofmeister CC, He X, Marsh HC, Devine SM, Yu JFLT3L and plerixafor combination increases hematopoietic stem cell mobilization and leads to improved transplantation outcome.Biol Blood Marrow Transplant 20 309-13 3/1/2014
  • Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju RK, Jacob ST, Yuneva M, Ghoshal KReciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.Hepatology 59 555-66 2/1/2014
  • Yu J, Freud AG, Caligiuri MALocation and cellular stages of natural killer cell development.Trends Immunol 34 573-82 12/1/2013
  • Wang LS, Kuo CT, Stoner K, Yearsley M, Oshima K, Yu J, Huang TH, Rosenberg D, Peiffer D, Stoner G, Huang YWDietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis.Carcinogenesis 34 2842-50 12/1/2013
  • Wang LS, Kuo CT, Huang TH, Yearsley M, Oshima K, Stoner GD, Yu J, Lechner JF, Huang YWBlack raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue.Cancer Prev Res (Phila) 6 1317-27 12/1/2013
  • Collins SM, Bakan CE, Swartzel GD, Hofmeister CC, Efebera YA, Kwon H, Starling GC, Ciarlariello D, Bhaskar S, Briercheck EL, Hughes T, Yu J, Rice A, Benson DM JrElotuzumab directly enhances NK cell cytotoxicity against myeloma via CS1 ligation: evidence for augmented NK cell function complementing ADCC.Cancer Immunol Immunother 62 1841-9 12/1/2013
  • Rao W, Zhang W, Poventud-Fuentes I, Wang Y, Lei Y, Agarwal P, Weekes B, Li C, Lu X, Yu J, He XThermally Responsive Nanoparticle-Encapsulated Curcumin and Its Combination with Mild Hyperthermia for Enhanced Cancer Cell Destruction.Acta Biomater in press 10/26/2013
  • Park IK, Trotta R, Yu J, Caligiuri MAAxl/Gas6 pathway positively regulates FLT3 activation in human natural killer cell development.Eur J Immunol 43 2750-5 10/1/2013
  • Liu L, Luo Z, Sun HL, Cui R, Wei H, Kim T, Lee TJ, Jeon YJ, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM, Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ESInsulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer.Proc Natl Acad Sci U S A 110 15043-8 9/10/2013
  • Yu J, He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MAMicroRNAs activate natural killer cells through Toll-like receptor signaling.Blood 121 4663-71 6/6/2013
  • Alvarez-Breckenridge CA, Yu J, Caligiuri MA, Chiocca EAUncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy.Oncoimmunology 2 e23658 4/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu