Patrick L Green PhD


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Patrick L Green PhD
Assoc Dean Res & Graduate StudiesCollege of Veterinary Medgreen.466@osu.edu
Veterinary Medicine Acad Bldg 1900 Coffey Road Columbus Ohio 43210
Phone:614-688-4899Alternate Phone:614-688-3554Fax: 614-292-6473
  • Viral Oncology
  • Administrative

General Research Interest

Molecular Pathogenesis of Human T-cell Leukemia Virus (HTLV) Molecular Biology of Retrovirus Replication T-cell Activation/Transformation

Research Description

The laboratory of Patrick Green is internationally recognized for their contributions to the understanding of the molecular basis of T-lymphocyte transformation and induction of leukemia/lymphoma and neurological disease by the human T-cell leukemia viruses (HTLVs). The Green lab has three areas of research focus investigating viral and cellular regulators of HTLV gene expression/replication, cellular transformation, and virus survival or persistence in the infected host. 

Current Publications

  • Anupam R, Doueiri R, Green PLThe need to accessorize: molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycle.Front Microbiol 4 275 9/17/2013
  • Kannian P, Fernandez S, Jones KS, Green PLHuman T lymphotropic virus type 1 SU residue 195 plays a role in determining the preferential CD4+ T cell immortalization/transformation tropism.J Virol 87(16) 9344-52 8/1/2013
  • Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia MBET proteins promote efficient murine leukemia virus integration at transcription start sites.Proc Natl Acad Sci U S A 110(29) 12036-41 7/16/2013
  • Enose-Akahata Y, Abrams A, Massoud R, Bialuk I, Johnson KR, Green PL, Maloney EM, Jacobson SHumoral immune response to HTLV-1 basic leucine zipper factor (HBZ) in HTLV-1-infected individuals.Retrovirology 10 19 2/13/2013
  • Doueiri R, Anupam R, Kvaratskhelia M, Green-Church K, Lairmore MD, Green PLComparative host protein interactions with HTLV-1 p30 and HTLV-2 p28: insights into difference in pathobiology of human retroviruses.Retrovirology 9 64 8/9/2012
  • Yin H, Kannian P, Dissinger N, Haines R, Niewiesk S, Green PLHuman T-cell leukemia virus type 2 antisense viral protein 2 is dispensable for in vitro immortalization but functions to repress early virus replication in vivo.J Virol 86(16) 8412-21 8/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu