Expertise

The Biostatistics Core Shared Resource (BCSR) offers cancer investigators a centralized resource for expertise in the biostatistical and computational aspects of clinical, basic and population-based research. Utilizing the BCSR’s services and expertise, cancer researchers can collaborate on all facets of study design, data management and statistical analysis of clinical, epidemiological, public health and laboratory research data.

BCSR Director: David Jarjoura, PhD

BCSR Associate Director for Basic Science Support: Soledad Fernandez, PhD

Cancer Control, Survey Sampling, Phase III Trials: Erinn Hade, MS

Statistical Programming: Keding Hua, MS 

Cancer Control, Immunology: Amy Lehman, MAS

Cancer Control: Stan Lemeshow, PhD

Phase I/II/III Clinical Trials: Xiaobai Li, PhD

Laboratory Experimental Design: Xiaokui (Molly) Mo, PhD, MAS

Phase I/II/III Clinical Trials: Xeuliang (Jeff) Pan, PhD

Chemoprevention, Phylogenetics, Phase I/II Trials: Dennis Pearl, PhD

Phase I/II Trials: Gary Phillips, MAS

Bio-assays, Laboratory Experiments, Diagnostic Studies: Kyle Porter, MAS 

Cancer Epidemiology: Julie Stephens, MS

Phase I/II/III Clinical Trials, Diagnostic Studies: Lai Wei, PhD

Statistical Modeling Techniques: Vedat Yildiz

Cancer Control, Phase III Trials: Greg Young, MS

Microarray Analysis: Lianbo Yu, PhD

Microarray Analysis, Data Visualization: Jianying Zhang, PhD

Laboratory Experimental Design, Microarray Analysis: Xiaoli Zhang, PhD, MAS



David Jarjoura, PhD, BCSR director, manages and coordinates all services provided to OSUCCC members, and establishes unit policies and priorities. 

Dr. Jarjoura is the Director of the Center for Biostatistics and Research Professor in OSU’s Division of Biostatistics, College of Public Health.  He is the Biostatistics Core director of four NCI P01 grants and a SPORE grant and serves as the director of the Biostatistics and Research Design Program of the Center for Clinical and Translational Science.  With more than 25 years of experience in collaborating with biomedical investigators on translational laboratory experiments and large, randomized disease management trials, Dr. Jarjoura is an expert in linear mixed models and multiple endpoint hypothesis testing in randomized trials. He is most active in proposal planning and design and  mentoring new biostatisticians as well as new clincial and laboratory investigators.

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Soledad Fernandez, PhD, is the Associate Director for Basic Science Support for BCSR support as well as the Associate Director of the Center for Biostatistics and a Research Associate Professor in the Division of Biostatistics in the College of Public Health.  

Dr. Fernandez currently serves as director of Biostatistics Cores in two P01s: oncogenic RNA viruses and genetic analysis of breast tumor microenvironment. She is an expert in statistical genetics as well as basic science research support. She focuses on planning, design and proposal preparation support to OSUCCC members engaged in laboratory research, and mentoring new biostatisticians. Dr. Fernandez also serves as a biostatistical reviewer for the CSRC.

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Erinn Hade, MS, supports clinical trial and observational study designs in all cancer research programs. In particular she supports the Cancer Control program’s clinical trials and survey studies.  She is involved with two international breast cancer Phase III clinical trials out of the MCC Scientific Program, survey and observational study design and analysis for the Cancer Control (CC) program, and clinical trial design for the ET Scientific Program.


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Keding Hua, MS, provides statistical and programming support for the BCSR and offers cancer investigators expertise in simulation programming, bootstrapping and modeling.

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Amy Lehman, MAS, an expert in statistical modeling and programming, works with Cancer Control Investigators and with the Immunology program. For nearly a decade, Ms. Lehman has offered her expertise and support to cancer investigators.

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Stan Lemeshow, PhD, focuses his expertise on Cancer Control research – especially fitting in light of his role as dean of OSU’s College of Public Health and his numerous professional accomplishments, including writing and publishing books on logistic regression, survival analysis and sampling methods.

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Xiaobai Li, PhD, is an expert in modeling complex physiological processes using clinical measurements over time and in clinical trial design.  She has more than five years of experience in these areas and received training in clinical trial design at both the FDA and NIH. She provides design and implementation support for clinical trials across all programs.  In addition she serves as a biostatistical reviewer for the CSRC.

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Xiaokui (Molly) Mo, PhD, MAS, holds a doctorate in Biochemistry and a Master of Applied Statistics degree. Dr. Mo, has extensive experience in laboratory experimental design, which greatly enhances our communications with  laboratory investigators. She provides collaboration on design and measurement issues that arise in discussions with laboratory investigators primarily in the MBCG, VO and IMM Scientific Programs.

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Xueliang (Jeff) Pan, PhD, has developed strong collaborative relationships with investigators in MCC and ET, and has provided leadership in preparing a P01 in chemoprevention.  He supports clinical trial and observational study design for these and other OSUCC programs, and has expertise in image analysis and linear mixed modeling.

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Dennis Pearl, PhD, is a senior biostatistical reviewer for the CSRC and serves on the CSRC executive committee. He also supports the Molecular Carcinogenesis and Chemoprevention (MCC) program. His primary interest is in phylogenetics.

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Gary Phillips, MAS, has developed expertise in Phase I/II clinical trial designs as well as logistic regression and linear mixed modeling.  He provides support in planning, design, and analysis across programs and presents statistical lectures to fellows and junior faculty in the OSUCCC.  He is a biostatistical reviewer for the CSRC and a member of the DSM executive committee, which meets monthly to monitor AE reports for all Phase I/II clinical trials.

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Kyle Porter, MAS., provides data base management and statistical programming and analysis support for all OSUCC programs.   He has expertise in non-linear mixed modeling, as well as bio-assay statistical design and analysis.  He provides support for all programs of the OSUCCC.

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Julie Stephens, MS, provides leadership for coordination of the BSR members and provides planning, design and analysis support, and database management for all programs in the OSUCCC.   She also analyzes the Ohio Cancer Incidence Surveillance Systems data in support of cancer research programs and for public health reports, including the American Cancer Society’s Facts & Figures.

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Lai Wei, PhD, is an expert in modeling multiple measures over time and conducted research on re-estimation of sample size for time-to-event clinical trials and mouse model experiments.  She has also developed expertise in statistical genetics to support the MBCG and VO programs.  Dr. Wei serves as a biostatistical reviewer for the CSRC and provides analysis and design support for Phase I/II clinical trials.

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Vedat Yildiz is the most recent employee to join the Center for Biostatistics. Yildiz has been with the OSUCCC since 2010 after receiving an MS in statistics from Western Michigan University in 2004. He developed a strong background in programming and statistical modeling techniques while working for the safety pharmacology group that provide statistical support to Pharmaceutical Product Development Group at Battelle Institute before coming to OSU.

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Greg Young, MS, has expertise in survival analysis and linear models and provides design and analysis support for all programs of the OSUCCC.  He plays a critical role in managing the complexities of data retrieval and management in the international breast cancer Phase III clinical trials.  He is an expert in outpatient clinical trials, specifically with data capture and management, and he has also offered statistical lectures and journal club reviews for fellows and facutly in the OSUCCC.

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D, is the leader of the BCSR Microarray Analysis team and an expert in microarray statistical design and analysis, and other high dimensional designs. As such, Dr. Yu has been instrumental in developing innovative approaches in microarray analysis, yielding more reliable and transparent results than those from standard microarray methods.  Dr. Yu’s Microarray Analysis team  published a paper on normalization methods for micro-RNA data, and the group has developed robust smoothing and filtering methods for small sample microarray studies. Dr. Yu supports the MBCG, VO and IMM programs.

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Jianying Zhang, PhD, offers expert support for microarray analysis and provides leadership in data visualization of high dimensional data.  In addition, Dr. Zhang provides design and analysis support to the MBCG, MCC, ET and IMM Scientific Programs. 

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Xiaoli Zhang, PhD, MS, holds a doctorate in Molecular Biology and a Master of Science degree in Statistics.  Her strong background in molecular biology and biochemistry and extensive experience in basic laboratory experimental design and data analysis provides a great advantage to clarifying statistical issues with investigators, especially for planning and design. She has developed expertise in supporting grant preparation activities, and greatly enhances the communication between investigators and biostatisticians, especially in P01 grants. She serves as a biostatistical reviewer for the CSRC and collaborates on planning and design and measurement issues that arise in discussions with laboratory investigators and well as microarray analysis primarily in the MBCG, ET and IMM Scientific Programs.

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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu