The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expertise to members who utilize animal models to study human disease. The CPMPSR comparative pathologists are experts in normal anatomy and physiology as well as background age- and strain/breed-related lesions of various animal models.
Located in OSU’s College of Veterinary Medicine, the CPMPSR has access to considerable veterinary pathology expertise from 11 additional board-certified veterinary pathologists in the Department of Veterinary Biosciences. The College of Veterinary Medicine staff also includes veterinary radiologists, ophthalmologists and cardiologists, whose expertise is available to CPMPSR clients.
CPMPSR Director: Krista M.D. La Perle, DVM, PhD, Dipl. ACVP
CPMPSR Associate Director: Brad Bolon, DVM, MS, PhD, Dipl. ACVP and ABT
Medical Laboratory Technologist: Jody Sneddon, MT (ASCP) SH
Research Assistant: Julie Rectenwald, AA
Lab Demonstrator (Virtual Microscopy): Jenny Bolon, AA
Histology/Immunohistochemistry Laboratory Manager: Alan Flechtner, BS, HTL (ASCP)
Histotechnician: Bill Kimble
Histotechnician: Anne Saulsbery, AA, HT (ASCP)
Immunohistotechnician: Florinda Jaynes, HT (ASCP)
Krista M.D. La Perle, DVM, PhD, Dipl. ACVP, is the CPMPSR director and an associate professor at The Ohio State University.
In her CPMPSR director role, Dr. La Perle oversees all CPMPSR operations and projects, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. Additionally, she meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.
Dr. La Perle is an expert in veterinary comparative pathology: she completed her postdoctoral training in veterinary anatomic pathology at Ohio State and is board certified by the American College of Veterinary Pathologists (ACVP). In addition, she obtained her PhD in experimental and molecular pathology from Ohio State where her National Institutes of Health-funded research focused on animal models of thyroid cancer and developing gene therapy strategies of sodium/iodide symporter-mediated radionuclide imaging and therapy for cancer.
Prior to her position as the CPMPSR director, Dr. La Perle established the Genetically Engineered Mouse Phenotyping Service and was director of the Laboratory of Comparative Pathology for Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University and Rockefeller University in New York City.
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Brad Bolon, DVM, MS, PhD, Dipl. ACVP and ABT, is the CPMPSR associate director and an associate professor at The Ohio State University.
Dr. Bolon shares responsibility for all projects with Dr. Krista La Perle, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. Additionally, he meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.
Before his recent recruitment to OSU, Dr. Bolon founded GEMpath, Inc., a company that supported basic bio/pharmaceutical research, emphasizing morphologic analysis of genetically engineered (especially developing) mice, target validation, and efficacy and safety studies (rats, rabbits, dogs, primates) for proteins and small molecules. Dr. Bolon has led teams that morphologically characterized genetically engineered animal models for human cardiovascular, endocrine, metabolic, and neural diseases using in situ molecular assays (e.g., nucleic acid hybridization), and has been a leader in designing and managing core services for microscopy, photomicrography, and digital imaging in his roles at Pathology Associates International, Wyeth-Ayerst Research and Amgen. He has an extensive background in veterinary pathology with specific training and expertise in comparative pathology, developmental pathology, neuropathology, and toxicologic pathology, including training to assess anatomic, behavioral, and neurochemical disruption in brains of prenatal and neonatal mice exposed to either fungal toxins or industrial solvents.
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Jody Sneddon, MT (ASCP) SH, is a medical laboratory technologist for the CPMPSR.
With over 24 years of valuable experience working in clinical pathology laboratories at Nationwide Children’s Hospital, Sneddon processes all clinical pathology specimens for in-house analysis, submits specimens to reference laboratories, reports clinical pathology results to investigators and pathologists, and archives results and blood smears/cytology slides.
Sneddon received her Bachelor of Science degree in Medical Technology from The Ohio State University and is certified as a Medical Technologist and a Specialist in Hematology from the American Society for Clinical Pathology.
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, AA, AHT, MLT, research assistant for the CPMPSR, is an expert coordinating histopathology for good laboratory practice (GLP) animal studies and has more than 15 years of experience in the field.
Working in tandem with CPMPSR Senior Research Associate Deborah Devor-Henneman, Rectenwald processes samples, performs gross dissection of animals, collects blood samples, weighs animals and tissues, identifies gross lesions, and harvests and trims tissues for histology. Additionally, she takes digital gross photographs and performs radiography, offers investigators instruction on tissue collection, fixation and trimming, and assists with organizing and coordinating their animal studies.
Rectenwald received Associate of Applied Sciences degrees in Animal Health Technology and Medical Laboratory Technology from Columbus Technical Institute and Columbus State Community College, Columbus, OH, respectively.
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Jenny Bolon, AA is a veterinary technologist and virtual microscopy lab demonstrator for the CPMPSR. Her primary responsibilities for the CPMPSR are to perform digital slide scanning with our Aperio ScanScope XT and help Drs. La Perle and Bolon fine tune algorithms for quantitative image analysis using the Aperio Toolbox Software. Prior to joining the CPMPSR and the Department of Veterinary Biosciences in December 2013, Jenny supported radiographic, fluoroscopic and MRI imaging of OSU Veterinary Medical Center patients for over 23 years.
[back to top]Alan Flechtner,
BS, HTL (ASCP), is the CPMPSR Histology/Immunohistochemistry laboratory manager. A histotechnologist certified by the American Society of Clinical Pathologists (ASCP), Flechtner has more than 17 years of experience in all aspects of histology/immunohistochemistry and is responsible for technical and administrative oversight of the CPMPSR histology/immunohistochemistry lab.
Flechtner received his Bachelor of Science in Biology from Heidelberg College, Tiffin, OH.
AA, HT (ASCP), histotechnician for the CPMPSR, offers investigators more than 12 years of expertise in embedding, sectioning and performing routine and special histochemical stains.
Saulsbery received her Associate of Applied Sciences degree from Columbus State Community College, Columbus, OH, and she is certified by the American Society of Clinical Pathologists (ASCP).
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Bill Kimble, CPMPSR histology technician, offers investigators more than 12 years of expertise in embedding, sectioning and performing routine and special histochemical stains.
Kimble has a certificate in Histology from Columbus State Community College, Columbus, OH.[back to top]Florinda Jaynes,
HT (ASCP), CPMPSR immunohistotechnician, offers investigators more than 25 years of experience in histology and immunohistochemistry.
She is responsible for all aspects of the CPMPSR’s immunohistochemistry, including optimizing antigen retrieval techniques, novel antibodies and numerous detection methods.
Jaynes is certified by the American Society of Clinical Pathologists (ASCP).[back to top]