Genetically Engineered Mouse Modeling

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Mouse modeling is a powerful tool, highly effective for elucidating disease mechanisms and interrogating novel experimental therapeutics. The Genetically Engineered Mouse Modeling Shared Resource (GEMMSR) is a recently established facility available to all investigators on the Ohio State campus who currently work or intend to work with mouse models of human diseases.

The GEMMSR director and staff have extensive experience in the generation and maintenance of genetically engineered mouse lines. GEMMSR can assist in the generation of classical transgenic lines by pronuclear injection and targeted lines (knock-out, knock-in, conditional) by ES cell technology. It also offers sperm or embryo cryopreservation, rederivation and in vitro fertilization (IVF) services.

The GEMMSR director and staff are particularly interested in helping investigators with minimal experience who would like to start using mouse models to complement and strengthen their in vivo studies or grant proposals.

Director: Vincenzo Coppola, MD


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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu