The Leukemia Tissue Bank Shared Resource (LTBSR) provides technical expertise and training to facilitate the successful translation of basic leukemia research to the clinical setting via an extensive repository of tissue samples and accompanying pathologic, cytogenetic and clinical data for ready correlation of clinical and biological results.
Committed to furthering translational research efforts for OSUCCC–James members and the cancer research community, the LTBSR provides investigators with training and technical support as well as procurement, processing, storage, retrieval and distribution of clinical research materials.
LTBSR Director: Guido Marcucci, MD
Laboratory Supervisor: Donna Bucci, BS
Clinical Research Data Coordinator: Christopher Manring, BS
Guido Marcucci, MD, director of the LTBSR, is an associate professor of medicine in The Ohio State University’s Hematology/Oncology Division. He is also jointly appointed in Ohio State's Department of Molecular Virology, Immunology and Medical Genetics, as well as in Ohio State's College of Pharmacy’s Division of Pharmaceutics.
Also the director of the Myeloid Malignancy Program at OSUCCC–James, Dr. Marcucci focuses on drug development and the discovery of molecular prognostic biomarkers in acute myeloid leukemia, for which he is NCI-funded. He is a member of the CALGB Leukemia Science Committee and the principal investigator on several CALGB and OSU clinical and correlative study protocols.
The author and coauthor of numerous manuscripts published in peer-review journals such as the New England Journal of Medicine, Cancer Cell, Journal of Clinical Investigation, Journal of Clinical Oncology and Blood, Dr. Marcucci earned his medical degree from the Catholic University of Sacred Heart, Rome, Italy. He completed his internal medicine internship and residency at the State University of New York, Buffalo, New York, and a two-year oncology fellowship at the Roswell Park Cancer Institution, also in Buffalo.
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Donna Bucci, BS, the LTBSR laboratory supervisor, brings 25 years of biomedical laboratory expertise to the LTBSR. She has co-authored more than 20 professional publications and abstracts, creates technical manuals and manages clinical trial sites for molecular virology diagnostic assays and a tissue-based assay for testing chemotherapeutic agents’ effectiveness on patient tumor samples.
Bucci’s areas of expertise include cell biology and immunology with an emphasis on Immunohistochemistry, microscopy and flow cytometric analysis.
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Christopher Manring, BS, is the clinical research data coordinator for the LTBSR. He is an expert in performing all aspects of routine sample processing, including logging samples from various studies, assigning unique identifiers, and preparing centrifuge tubes, eppendorf tubes, counting vials and cryovials for viable cells.
Additionally, Manring prepares ficoll separated mononuclear cells from peripheral blood and bone marrow patient samples, performs cell counts, obtains viability data from samples, and determines allocation of each sample for various post-ficoll sample processing.
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