Expertise

The Pharmacoanalytical Shared Resource (PhASR) staff offers expertise in pharmacology, bioanalytical methodology and pharmacokinetics and is available for consultation on clinical or pre-clinical PK/PD experimental design and analysis.

PhASR Director: Kenneth K. Chan, PhD

Technical Director: Mitch A. Phelps, PhD

Research Asst. Professor: Zhongfa Liu, PhD

Adjunct Asst. Professor: Jeffrey S. Johnston, PhD

Research Associate: Yonghua Ling, PhD

Research Associate: Jeffrey A. Cotrill

Administrator: Joy E. Scott

Dr. Kenneth K. Chan, PhD, is the director of the Pharmacoanalytic Shared Resource as well as the director of the Biomedical Mass Spectrometry Laboratory in The Ohio State University’s College of Pharmacy. He is also a professor of Pharmaceutics and Internal Medicine at Ohio State's College of Pharmacy and College of Medicine.

Dr. Chan has extensive experience in the study of the pharmacokinetics, disposition and metabolism of anticancer drugs, and he was the principal investigator for the Preclinical Pharmacology Contract Studies of Antitumor Agents.

Additional expertise includes: advanced analytic methodology including various forms of gas chromatography, high pressure liquid chromatography, fluorescence, gas chromatograph-mass spectrometry, liquid chromatographic-mass spectrometry, tandem mass spectrometry, and stable isotope labeling and analytical application. He has also developed sensitive and specific methods for the analysis of numerous drugs and metabolites.

Formerly a faculty member of the University of Southern California and director of USC’s Pharmacoanalytic Core Laboratory, Dr. Chan joined Ohio State in 1992 where he served in the same role until assuming the PhASR director role.

He received his doctorate degree in pharmaceutical chemistry from the University of California at San Francisco. 

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Mitch A. Phelps, PhD, technical director for PhASR, is an assistant professor in Ohio State's College of Pharmacy, Division of Pharmaceutics and College of Medicine Department of Pharmacology.

Dr. Phelps has been with the OSUCCC–James for nearly four years applying his expertise in analytical methodologies and data modeling to study the disposition of novel anti-cancer agents. Dr. Phelps helped establish PhASR and supported its initial development in his previous role as operations manager. In his current role as technical director, Dr. Phelps manages project throughput, develops collaborative projects with new and existing users, and supports PK/PD/PGx modeling and data analysis.  His work has resulted in collaborations with other basic science and clinical researchers to conduct pre-clinical studies and clinical trials to advance the development of novel drug compounds.

Dr. Phelps received his doctorate in biophysics from Ohio State and post-doctoral training under Dr. Jim Dalton. He is a Fellow with Ohio State’s Center for Clinical and Translational Sciences.

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Zhongfa Liu, PhD, is a research assistant professor in Ohio State’s Division of Pharmaceutics in the College of Pharmacy and the manager of the Biomedical Mass Spectrometry Facility, which provides support for pre-clinical pharmacology studies through the National Cancer Institute. Dr. Liu provides PhASR researchers with analytical and translational expertise for method development and application of pharmacoanalytic methods.

Dr. Liu’s research interests include bioanalytical mass spectrometry; post-translational protein and DNA modification, identification, quantitation  and validation of epigenetic biomarkers; epigenetic modulation by dietary supplements; natural products and their synthetic analogs; drug analytical method development; preclinical and clinical pharmacokinetics; metabolite and pharmacodynamics; and antisense drug therapy.

Dr. Liu received his doctoral degree in chemistry from Case Western Reserve University, Cleveland, Ohio, and his post-doctoral training in mass spectrometry from Ohio State under Dr. Chan.

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Jeffrey S. Johnston, PhD, is an adjunct assistant professor in Ohio State’s College of Pharmacy, Division of Pharmaceutics, and he serves as a research specialist for PhASR.

Dr. Johnston supports the development of bioanalytical methods for pharmacokinetic and pharmacodynamic studies, including quantitative proteasome inhibition assays. Dr. Liu also supports pharmacokinetic and pharmacodynamic data analysis.

Dr. Johnston received his doctorate in pharmaceutics from Ohio State. 

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Yonghua Ling, PhD,  research associate, maintains extensive expertise in quantification of small molecules in biological matrices by LC-MS/MS, drug metabolism and disposition by LC-MS/MS, bioanalytical method development with solid phase, liquid-liquid extractions and protein precipitation. Dr. Liu conducts method development and validation, sample processing and data analysis, and PK experimental design.

Dr. Ling received her doctoral degree in physical chemistry from the University of Miami, and she completed her post doctoral training at Ohio State under Dr. Chan.

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Jeffrey A. Cotrill, research associate, offers expertise in developing molecular biological and analytical assays to quantify drugs and biomolecules.

Mr. Cotrill supports bioanalytical method development, validation and sample analaysis. He also has primary responsibility for the maintenance of equipment, sample inventories and PhASR protocols.

Mr. Cotrill received his bachelor’s from Ohio State in molecular genetics and microbiology.

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Joy E. Scott, an administrative associate in Ohio State's College of Pharmacy, provides administrative support within PhASR.

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The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu