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Breast Clinical Trials


With an emphasis on transdisciplinary translational research, the OSUCCC-James facilitates investigator-initiated early phase clinical trials and participates in many cooperative groups.

Protocol No.PITitle
OSU-0107Doreen AgneseProspective Cohort Study of BRCA1 & BRCA2 Carriers
OSU-10129Dawn AllainThe Value of Genetic Counselors in Genetic Testing for Hereditary Breast-Ovarian Cancer
OSU-9942Barbara AndersenStress Immunity & Breast Cancer Recurrence
CALGB-60202Clara BloomfieldEmbedded companion to CALGB 40101: Drug Metabolism and Transport PG in Breast CA patients on CALGB 40101
OSU-09142William CarsonMyeloid-Derived Suppressor Cell Function in Breast Cancer Patients
OSU-06010Kevin EvansLymph Node Evaluation in the Axilla of Symptomatic Older Women During Breast Sonography.
NSABP-B-43William FarrarA Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy.
NSABP-B-47William FarrarRandomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
OSU-12033Gayle GordilloMASTECTOMY RECONSTRUCTION OUTCOMES CONSORTIUM (MROC) STUDY
OSU-07123Stacey HindyEpidemiology of Breast Implant Infections in Post-Mastectomy Breast Cancer Patients Undergoing Breast Reconstruction
OSU-06007Kimberly KellyPerceived Recurrence Risk of Breast Cancer.
OSU-09005Kimberly KellyBreast Cancer Patients Perceptions of Recurrence Risk and Treatment Expectations
OSU-06137Janice Kiecolt-GlaserBreast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
CALGB-150714Rachel LaymanEmbedded Companion Study to CALGB-40502
CALGB-60704Rachel LaymanEmbedded Companion Study to CALGB-40502
OSU-0252Joanne LesterEvaluation and Treatment of Urogenital Atrophy in High Risk Breast Patients and Breast Cancer Survivors
OSU-11092Joanne LesterEffect of Survivorship Care Planning on Distress: A Randomized Control Trial with Leukemia and Breast Cancer Survivors.
SWOG-S1007Maryam LustbergA Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less
OSU-12127Maryam LustbergA randomized, double-blind, placebo controlled, phase II study of BKM120 plus paclitaxel in patients with HER2 negative inoperable locally advanced or metastatic breast cancer, with or without PI3K pathway activation
OSU-11022Maryam LustbergPrevention of Aromatase Inhibitor-Induced Joint Symptoms with Omega 3 Fatty Acid Supplementation: a randomized placebo controlled pilot study
OSU-08140Maryam LustbergIsolation and Characterization of Circulating Tumor Cells in Localized and Metastatic Breast Cancer Patients by Immunocytochemical and PCR Detection after Immunomagnetic Cell Enrichment
CALGB-60701Ewa MrozekEmbedded Companion to CALGB-40601
CALGB-150702Ewa MrozekEmbedded Companion to CALGB-40601
OSU-12061Erin OlsonA two-cohort, open-label, multicenter Phase II trial assessing the efficacy and safety of pertuzumab given in combination with trastuzumab and vinorelbine in first line patients with HER2-positive advanced (metastatic or locally advanced) breast cancer
OSU-12109Erin OlsonYOUNG AND STRONG: An Education and Supportive Care Intervention Study for Young Women with Breast Cancer
OSU-12156Douglas PostIncreasing Adherence to Adjuvant Hormonal Therapy among Breast Cancer Patients: Phase I - Intervention Development
OSU-09012Douglas PostDeveloping a communication Tool for Appalachian Breast Cancer Survivors
OSU-07015Stephen Povoski8 Gauge Mammotome Vacuum-Assisted Biopsy Technique: Retrospective Chart Review
OSU-07016Stephen PovoskiAssessment of Nine Standardized Quadrantectomy Resection Margins During Breast Conservation Surgery for Breast Cancer: Retrospective Chart Review
ECOG-E2108Stephen PovoskiA Randomized Phase III Trial of the Value of Early Local Therapy for the Intact Primary Tumor in Patients with Metastatic Breast Cancer
RTOG-1119Allison QuickPHASE II RANDOMIZED STUDY OF WHOLE BRAIN RADIOTHERAPY IN COMBINATION WITH CONCURRENT LAPATINIB IN PATIENTS WITH BRAIN METASTASIS FROM HER2-POSITIVE BREAST CANCER A COLLABORATIVE STUDY OF RTOG AND KROG
OSU-10097Bhuvaneswari RamaswamyA Randomized Phase II Study of Fulvestrant vs. Fulvestrant in Combination with Bortezomib in Women with ER Positive Metastic Breast Cancer
OSU-08153Bhuvaneswari RamaswamyA Phase II Open-label Study of Subcutaneous CPG ODN (PF03512676) in Combination with Trastuzumab in Patients with Metastatic Breast Cancer
CALGB-150605Bhuvaneswari RamaswamyEmbedded Companion Study to CALGB-40503
CALGB-60605Bhuvaneswari RamaswamyEmbedded Companion Study to CALGB-40503
CALGB-150804Bhuvaneswari RamaswamyEmbedded companion study to CALGB 70604
CALGB-60803Bhuvaneswari RamaswamyEmbedded companion study to CALGB 70604
OSU-11127Leigha Senter-JamiesonThe impact of pregnancy during and after breast cancer on survival in carriers of BRCA1 and BRCA2 mutations
OSU-12112Charles ShapiroA Randomised, Double-blind, Parallel-group, Multicentre, Phase III Study to Compare the Efficacy and Tolerability of Fulvestrant (FASLODEXTM) 500 mg with Anastrozole (ARIMIDEXTM) 1 mg as Hormonal Treatment for Postmenopausal Women with Hormone Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Have Not Previously Been Treated With Any Hormonal Therapy (FALCON)
OSU-07088Charles ShapiroThe Columbus Breast Cancer Tissue Bank
OSU-0109Charles ShapiroHuman Breast Cancer and National Breast Tissue Bank
OSU-05082Amanda TolandVariants in High Risk Breast Cancer Genes and Contribution to Cancer Risk.
OSU-05102Amanda TolandIdentification of Human Cancer Susceptibility & Resistance Genes.
OSU-10152Miguel VillalonaPhase 1 Study of IMC-CS4, a Monoclonal Antibody Targeted to the CSF-1 Receptor (CSF-1R), in Subjects With Advanced Solid Tumors Refractory to Standard Therapy or for Which No Standard Therapy is Available
CALGB-150709Robert WesolowskiEmbedded Companion to CALGB-40603
CALGB-60703Robert WesolowskiEmbedded Companion to CALGB-40603
OSU-12187Robert WesolowskiSingle-Patient Compassionate Use Treatment using Trastuzumab Emtansine (T-DM1) For Her2-Positive Metastatic Breast Cancer
OSU-12018Robert WesolowskiA Phase 1b Study to Assess the Safety of PLX3397 and Paclitaxel in Patients With Advanced Solid Tumors
OSU-12020Robert WesolowskiMINT I Multi-Institutional Neo-adjuvant Therapy MammaPrint project I
OSU-12078Robert WesolowskiTHE BEACON STUDY (BREAST CANCER OUTCOMES WITH NKTR-102):A PHASE 3 OPEN-LABEL, RANDOMIZED, MULTICENTER STUDY OF NKTR-102 VERSUS TREATMENT OF PHYSICIAN¿S CHOICE (TPC) IN PATIENTS WITH LOCALLY RECURRENT OR METASTATIC BREAST CANCER PREVIOUSLY TREATED WITH AN ANTHRACYCLINE, A AXANE, AND CAPECITABINE
RTOG-1005Julia WhiteA PHASE III TRIAL OF ACCELERATED WHOLE BREAST IRRADIATION WITH HYPOFRACTIONATION PLUS CONCURRENT BOOST VERSUS STANDARD WHOLE BREAST IRRADIATION PLUS SEQUENTIAL BOOST FOR EARLY-STAGE BREAST CANCER
CALGB-40903Lisa YeePHASE II STUDY OF NEOADJUVANT LETROZOLE FOR POSTMENOPAUSAL WOMEN WITH ESTROGEN RECEPTOR POSITIVE DUCTAL CARCINOMA IN SITU [DCIS)
CALGB-70806Lisa YeeVitamin D and Breast Cancer Biomarkers
OSU-10024Lisa YeeOmega 3 Fatty Acids and Breast Cancer Prevention: Protective Benefits of Increased Fish Consumption
OSU-08189Lisa YeeBreast Cancer Prevention by Letrozole in High Risk Women
OSU-0253Lisa YeeBreast Fine Needle Aspiration and Breast Duct Fluid Collection in High Risk Breast Patients.
OSU-9990Lisa YeeFatty Acids & Peroxisome Proliferator-Activated Receptors in Breast Cancer Prevention