Head and Neck Oncology Clinical Trials

Protocol No.PITitle
OSU-11010William CarsonA Phase I/II Trial of Cetuximab in Combination with Interleukin-12 Administered to Patients with Unresectable Primary or Recurrent Squamous Cell Carcinoma of the Head and Neck
RTOG-1008Virginia DiavolitsisA Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
RTOG-1216Virginia DiavolitsisRandomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of The Head And Neck
RTOG-0920Maura GillisonA Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer
OSU-11124Maura GillisonRandomized Double-Blind Phase II Trial of Everolimus Versus Placebo as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)
OSU-11169Maura GillisonA PILOT STUDY TO EXAMINE THE EFFECT OF RADIATION THERAPY ON HPV LATENCY AND REACTIVATION STATUS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE OROPHARYNX AND ORAL CAVITY
RTOG-3501Maura GillisonTRYHARD: A PHASE II, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED STUDY OF LAPATINIB (TYKERB®) FOR NON-HPV LOCALLY ADVANCED HEAD AND NECK CANCER WITH CONCURRENT CHEMORADIATION.
OSU-10028Maura GillisonEvaluation of inter-reader agreement for determination of HPV status for oropharynx cancers by use of HPV in situ hybridization and p16 immunohistochemistry
OSU-10038Maura GillisonPrevalence, Persistence, and Risk Factors for Oral Human Papillomavirus (HPV) Infection
OSU-10056Maura GillisonShort-term natural history of oral HPV infection among urban young adults: Study of Papillomavirus in Teens and Twenties (SPITT)
OSU-10128Maura GillisonPilot studies with Newly Diagnosed Squamous Cell Carcinoma of the Oropharynx
OSU-13254Maura GillisonPhase I Study of Platinum-based Chemoradiotherapy (CRT) with Oral Rigosertib in Patients with Intermediate or High-risk Head and Neck Squamous Cell Carcinoma
OSU-14042Maura GillisonAn Open Label, Randomized Phase 3 Clinical Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Platinum-refractory Squamous Cell Carcinoma of the Head and Neck (SCCHN)
OSU-14014John GreculaA Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Escalating, Multicenter Study of SGX942 for the Attenuation of Oral Mucositis in Patients Being Treated with Concomitant Chemoradiation for the Treatment of Squamous Cell Carcinoma of the Head and Neck
ACRIN-6685Nathan HallA MULTICENTER TRIAL OF FDG-PET/CT STAGING OF HEAD AND NECK CANCER AND ITS IMPACT ON THE N0 NECK SURGICAL TREATMENT IN HEAD AND NECK CANCER PATIENTS
OSU-08095John KalmarThe Role of Direct Visual Fluorescence in Oral Examination
OSU-0361Michael KnoppDynamic Contrast Enhanced Magnetic Resonance Imaging for Non-Invasive Diagnostic Work-Up in Solid Tumors of the Eye and Orbit.
OSU-0456Jas LangTissue Procurement and Database for the Study of Molecular Events in Primary, Recurrent, and Metastatic Squamous Cell Carcinoma of the Head and Neck.
OSU-09052Susan MalleryEvaluation of Oral Rinse Formulations for Sustained Salivary levels of Black Raspberry Anthocyanins
OSU-07061Enver OzerA Pilot Study Assessing Transoral Robotic Surgery (TORS) for Oral and Laryngopharyngeal Benign and Malignant Lesions Using the Da Vinci Robotic Surgical System.
ECOG-E3311Enver OzerPhase II Randomized Trial of Transoral Surgical Resection followed by Low-dose or Standard-dose IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer
RTOG-1221Enver OzerRandomized Phase II Trial of Transoral Endoscopic Head And Neck Surgery followed by Risk-Based IMRT and Weekly Cisplatin versus IMRT and Weekly Cisplatin for HPV Negative Oropharynx Cancer
ECOG-E1305Panayiotis SavvidesA Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer
OSU-13141Panayiotis SavvidesA Phase I/II clinical trial of sorafenib in combination with cisplatin and docetaxel in patients with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN)
OSU-09120Ted TeknosA Phase I Trial Of Vorinostat In The Treatment Of Advanced Laryngeal, Hypopharyngeal, Nasopharyngeal And Oropharyngeal Squamous Cell Carcinoma Of The Head And Neck.

With an emphasis on transdisciplinary translational research, the OSUCCC-James facilitates investigator-initiated early phase clinical trials and participates in many cooperative groups.

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu