Gregory Adams, PhD
Mentor: Joseph Palumbo, MD
Project: Thrombin promotes prostate cancer progression
Project Summary: Determine the contribution of the blood coagulation system to prostate cancer pathogenesis using various mouse models. The project will focus on the enzymatic action of thrombin on primary tumor growth
William Cantara, PhD
Mentor: Karin Musier-Forsyth, PhD
Project: Stuctural characterization of the 5'-UTR of the oncogenic HTLV-1 retrovirus
Project Summary: We aim to understand the three-dimensional structure of a key region within the genome of a cancer-causing virus. The results of this study will provide new drug targets for cancer therapy.
Dalia Elgamal, PhD
Mentor: John C. Byrd, MD
Project: PRMT5 dysregulation as a driver event in Richter's transformation
Project Summary: Determine the expression and function of PRMT5, an enzyme involved in repression of various cell cycle regulatory and tumor suppressor genes, in chronic lymphocytic leukemia (CLL) and Richter's transformation (RS). My project will provide insight on PRMT5 as a potential marker to identify CLL patients that will likely progress to RS. This study will offer vital information to develop new therapies for RS, a currently incurable disease.
Luiz Henrique de Lima Araujo, MD
Mentor: David Paul Carbone, MD, PhD
Project: Circulating microRNAs in non-small cell lung cancer treated with Vandetanib
Project Summary: Develop a molecular signature that will be used to select patients with advanced Non-Small Lung Cancer to receive a targeted therapy named vandetanib. The signature will be based on the expression of small molecules named microRNAs, which can be found in patients’ blood, and can be assessed before treatment beginning.
Kara Keplinger, MD
Mentor: Matthew Ringel, MD
Project: P21 activated kinase as a therapeutic target in Papillary Thyroid Cancer
Project Summary: Evaluate the effectiveness of new medications which block a protein called PAK21 in killing thyroid cancer cells. This may provide a new chemotherapeutic agent for a type of cancer
which has few effective medical therapies available.
Annette Ratcliff, PhD
Mentor: Patrick Green PhD & Jesse Kwiek, PhD
Project: Defining the Role of Fatty Acid Synthase in HTLV-1 Replication and T lymphocyte Transformation
Project Summary: We aim to understand how and why a cancer-causing virus changes the activity of an enzyme that produces new fatty acids in human cells. These studies may lead to the development of new cancer therapies.
Eric Samordnitsky, PhD
Mentor: Sameek Roychowdhury, MD, PhD
Project: Modeling acquired resistance fo molecularly targeted cancer therapies through next generation sequencing
Project Summary: We are learning that cancer is hundreds (maybe thousands) of different diseases, not just one disease. Even worse, when attacked with drugs, cancer learns how to fight off the drug. Therefore, we are developing a computer program to understand each cancer and help researchers and clinicians find the weak spot of a cancer at hand to choose the correct drugs to help treat that patient.