2010 Postdoctoral Pelotonia Fellows


Aruna Battu
Project: Role of histone modifications in cancer pathogenesis
Project Summary: Learn how modifications in histones, proteins that help compact DNA in the cells, are involved in the recognition and repair of DNA damage caused by ultra-violet (UV) rays. DNA damage caused by UV rays is the primary cause of skin cancers and identifying the role of histone modifications in DNA repair will eventually lead to the development of novel drug targets that can help cure skin cancer.




Hemant Bid
Project: Dual Targeting of the Type 1 Insulin‐like Growth Factor Receptor and its Ligands as an Effective Anti‐angiogenic Strategy for Sarcomas
Project Summary: Identify the mechanism by which IGF-1R binding antibodies fail to suppress tumor angiogenesis, and using this information develop effective approaches to suppress tumor angiogenesis. The findings will help researchers to design more effective angiogenesis-directed treatment of childhood sarcomas.


Enrico Caserta
Project: Tumor Suppression Functions of PTEN in Stromal Cells
Project Summary: Investigate the multiple roles played by an important protein, known to counteract the progression of cancer, and uncover some of the less known cancer protection mechanisms directed by this protein. The information obtained may eventually be used to develop novel and more efficient pharmacological therapies adding extra and more suited weapons to the war against cancer.

 

Nancy Engelmann
Project: Novel 13 C Tomato Carotenoids for Absorption and Metabolism Studies in Humans
Project Summary: Evaluate the absorption and metabolism of tomato carotenoids in human subjects. The goal is to better understand how tomato carotenoids, which are responsible for the red, orange, and yellow colors of tomatoes, may prevent or slow down prostate cancer.

 

Daniel Kiss
Project: Relationship of cytoplasmic processing bodies to the re-activation of microRNA-silenced mRNAs
Project Summary


 

I-Lu Lai
Project: Potentiation of the Antiproliferative Activities of PARP Inhibitors in TNBC cells via Chemical Genetic Silencing of BRCA1/2 by Novel Energy Restriction-Mimetic Agents
Project Summary: Study how novel energy restriction-mimetic agents (ERMA) and PARP inhibitor work together to block DNA repair pathway and to result in cancer cells death in Triple-negative breast cancer (TNBC). This may be provided to improve the effect of PARP inhibitors to BRCA1/2 functional TNBC.

Jiang Li
Project: Molecular Mechanism of DNA Repair by (6-4) Photolyase
Project Summary: This study will investigate the repair mechanism of Ultraviolet-damaged DNA by (6-4) photolyase, which may introduce an efficient way to prevent skin cancer.

 

Markus Mair
Project: Genetic Dissection of the Tumor Microenvironment
Project Summary: This study will investigate the repair mechanism of Ultraviolet-damaged DNA by (6-4) photolyase, which may introduce an efficient way to prevent skin cancer.


 

Chelsea Martin
Project: Pharmacologic inhibition of PI3 Kinase in genetically engineered mouse models of PTEN mutation-associated tumorigenesis
Project Summary: Many forms of cancer have an overactive PI3K pathway that encourages tumor growth. New cancer treatments are being developed to inhibit this particular pathway. My project will determine if the success of these new treatments will depend on the type of genetic mutation that activate the PI3K pathway in cancer cells. We will determine if these treatments can prevent cancer before it has formed and reduce cancers that have already formed.


Daisuke Ogawa
Project: Pharmacologic inhibition of PI3 Kinase in genetically engineered mouse models of PTEN mutation-associated tumorigenesis
Project Summary



Thierry Pecot
Project: Imaging of Mammary Glands in Mouse Models of Breast Cancer
Project Summary: Reconstruct and characterize fibroblasts, macrophages, endothelial and epithelial cells along the cancer progression and for different genotypes in the tumor micro-environment. The findings will help biologists to better understand the formation and development of cancer in the breast.

 

Parvathi Ranganathan
Project: Regulation of Acute Graft-Versus-Host Disease by microRNA-155
Project Summary




Shantibhushan Senapati
Project: Role of E2F7-8 in Hepatocyte Endoreplication and Hepatocellular Carcinoma (HCC)
Project Summary: Acute graft versus host disease (aGVHD) is a common complication of bone marrow transplants used to treat various blood cancers. The main goal of our research is to study the effect of a small genetic molecule called microRNA-155 in the regulation of aGVHD. Specifically we focus on the mechanism via which microRNA-155modulates the donor immune cells that cause aGVHD.



Anil Singh
Project: The PTEN Protein Interactome and Its Role in Tumor Progression
Project Summary: Identify novel cellular pathways and proteins controlled by PTEN, a gene that regulates cell growth and division and is frequently mutated or absent in a number of human cancers. When these cellular pathways are identified, they can be blocked by drugs in cancer cells to prevent their uncontrolled growth.



Takayuki Uchida
Project: Role of mouse ORC1 in endoreplication
Project Summary: Investigate the role of a fundamental regulator in mitotic replication, called ORC1, in endoreplication that occurs in some type of cancer cells to become resistant against anti-mitotic drugs. The findings of the specific molecular mechanism in endoreplication will allow us to disrupt endoreplication in cancer cells and kill them by anti-mitotic drugs.




Mumtaz Yaseen
Project: NF-κB Signaling and Metabolic Regulation of Sarcomas
Project Summary: Evaluate how a key intracellular signaling pathway, NF-κB, important for growth and survival in normal cells becomes chronically active in bone and muscle cancers. This investigation may provide a new insight into how a same signaling pathway contributes to cancer and cancer related metabolic disorders.

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu