Modeling Human Disease

The Genetically Engineered Mouse Modeling Shared Resource

Vincenzo CoppolaMouse modeling is a powerful, highly effective tool for understanding cancer etiology and investigating novel experimental therapeutics. The OSUCCC – James Genetically Engineered Mouse Modeling Shared Resource is available to all Ohio State investigators who work or intend to work with mouse models of human diseases.

Director Vincenzo Coppola, MD, is a former scientist with the NCI’s Mouse Cancer Genetics Program. He and his staff are particularly interested in helping investigators with minimal experience who would like to start using mouse models to complement and strengthen their in vivo studies or grant proposals.

The facility has extensive experience generating and maintaining genetically engineered mouse lines, including classical transgenic lines by pronuclear injection and targeted lines (knockout, knock-in, conditional) by embryonic stem cell technology. The facility also offers sperm or embryo cryopreservation, rederivation and in vitro fertilization (IVF) services.

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