Fellowship Publications

Selected Pelotonia Fellowship Publications 

Madhu M. Ouseph, Jing Li, Hui-Zi Chen, Thierry Pecot, Pamela Wenzel, John C. Thompson, Grant Comstock, Veda Chokshi, et al. (2012). Atypical E2F Repressors and Activators Coordinate Placental Development. Developmental Cell 22, 849-862

Zorko NA, Bernot KM, Whitman SP, Siebenaler RF, Ahmed EA, Marcucci GG, Yanes DA, et al. Mll-Partial Tandem Duplication and Flt3-Internal Tandem Duplication in a Double Knock-in Mouse Recapitulates Features of Counterpart Human Acute Myeloid Leukemias. Blood. 2012. Accepted.

Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, et al. (2011). Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha. Cancer Res 71, 561-571

S. S. Rao, S. Bentil, J. DeJesus, J. Larison, A. Hissong, et al. (2012). Inherent interfacial mechanical gradients in 3D hydrogels influence tumor cell behaviors. PLoS ONE. In Press

Dworkin, M., et al. Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations, Journal of the Royal Society Interface, February 2012

Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, et al. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 Nature Cell Biology, 2011 Dec 18;14(2):159-67

Kauffman, K.J.; et al. Optimization of Rapamycin-Loaded Acetalated Dextran Microparticles for Immunosuppresion. Int. J. Pharm. 2012; 422(1-2): 356-363

B. Kodgire P, Mukkawar P, North JA, et al. Nucleosome Stability Dramatically Impacts Targeting of Somatic Hypermutation. Mol. Cell. Biol. Epub 2012 Mar 5

C. Simon M, North JA, et al. Histone Fold Modifications Control Nucleosome Unwrapping and Disassembly. Proc Natl Acad Sci USA. 2011. 108(31):12711-6. Epub 2100 Jul 18

D. Forties RA, North JA, et al. A Quantitative Model of Nucleosome Dynamics. Nucleis Acids Res. 2011. 39(19):9306-13. Epub 2011 Jul 14

E. North JA, et al. Phosphorylation of Histone H3(T118) Alters Nucleosome Dynamics and Remodeling. Nucleic Acids Res. 2011. 39(15):6465-74. Epub 2011 May 16

Studebaker AW, Hutzen B, et al. Oncolytic measles virus prolongs survival in a murine model of cerebral spinal fluid-disseminated medulloblastoma. Neuro Oncol 2012, 14(4):459-470

Lapalombella R, Yeh YY, et al. Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals. Cancer Cell. (Accepted in January 2012)

Ahn-Jarvis, JH., et al. Optimizing isoflavone-rich food delivery systems for human clinical trials In: Preedy, V.(Ed.) Food and Nutritional Components in Focus, Royal Society of Chemistry Publishing, Cambridge, UK in press, October 2012

Gurkan OU, He C, Zielinski R, et al. Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilatorassociated lung injury. Experimental Lung Research. 2011 Dec; 37(10):575-84

Bhattacharya S, Sandy A, et al. (2010). Unwinding protein complexes in ALTernative telomere maintenance. J Cell Biochem 109, 7-15

Chen MC, Chen CH, Chuang HC, et al. (2011), Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology. 53, 148-59

Lee SL, Hsu EC, Chou CC, Chuang HC, et al. (2011), Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 54, 6364-74

Smith SB, Kiss DL, et al. Pronounced and extensive microtubule defects in a Saccharomyces cerevisiae DIS3 mutant. Yeast. 2011 Nov;28(11):755-69.

Machemer, K. et al. Interplay of MYB factors in differential cell expansion, and consequences for tomato fruit development. Plant J. 2011 Oct; 68 (2) 337-50

Asp ML, Tian M, Kliewer KL, et al. Rosiglitazone delayed weight loss and anorexia while attenuating adipose depletion in mice with cancer cachexia. Cancer Biol Ther. 2011; 12 (11): 957-65

Bid HK, et al. Potent inhibition of angiogenesis by the IGF-1 receptortargeting antibody SCH717454 is reversed by IGF-2. Mol Cancer Ther. 2012 Mar;11(3):649-59. Epub 2011 Dec 21

Bid HK, et al. Targeting angiogenesis in childhood sarcomas. Sarcoma. 2011;2011:601514. Epub 2010 Dec 9

Bid HK, et al. Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. PLoS One. 2012;7(4):e35513. Epub 2012 Apr 17

Bo Wang, et al. Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1α. Hepatology, 2012 in press

Lu C.H., Choi J.H., Engelmann Moran N., et al. Laboratory-scale production of 13C-labeled lycopene and phytoene by bioengineered Escherichia coli. J. Agric. Food Chem. 2011, 58(18)9996-10005

Ford N.A., Engelmann Moran N., et al. An interaction between carotene-15,15’-monooxygenase expression and consumption of a tomato or lycopene-containing diet impacts serum and testicular testosterone. Int J Cancer. 2011, Epub ahead of print

Engelmann N.J., et al. Nutritional aspects of phytoene and phytofluene, carotenoid precursors to lycopene. Adv. Nutr. 2011, 2 (1) 51-61

Thavendiranathan, P., Walls, M., Giri, S., Rajagopalan, S., Moore, S., et al. (2012). Improved detection of myocardial involvement in acute inflammatory cardiomyopathies using T2 mapping. Circulation: Cardiovascular Imaging, 5, 1, 102-110

Cummings HE, Barbi J, Reville P, Oghumu S, Zorko N, et al. Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis. Proc. Natl. Acad. Sci. USA 2012;109(4):1251-6

Li X, Wang Q, Yu X, Liu H, Yang H, Zhao C, Liu X, Tan C, et al. (2011). Arabidopsis cryptochrome 2 (CRY2) functions by the photoactivation mechanism distinct from the tryptophan (trp) triad-dependent photoreduction. Proc. Natl. Acad. Sci. USA 108: 20844-20849

Liu Z, Tan C, et al. (2011). Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase. Proc. Natl. Acad. Sci. USA 108: 14831-14836

Meenach, S.A.; Kim, Y.J.; Kauffman, K.J.; et al. Synthesis, Optimization, and Characterization of Camptothecin-Loaded Acetalated Dextran Porous Microparticles for Pulmonary Delivery. Mol. Pharm. 2012; 9(2): 290-298.

Grierson, P., et al. (2012). BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription. Hum. Mol. Genet., 21, 1172-1183.

DeFraia, C., et al. (2011). Analysis of retrotransposon activity in plants, In: Epigenetic Phenomena in Plants: Understanding and Analysis, Charlie Spillane and Peter McKeown ed. Methods in Molecular Biology. Humana Press. In press

Gonzalez-Escobedo, G., et al. (2011). Chronic and acute infection of the gallbladder by Salmonella. Understanding the carrier state. Nat Rev Microbiol, 9 (1), 9-14

Nasser MW, Qamri Z, Deol YS, et al. (2011). S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways. Cancer Research, 72(3):604-15

Deol YS, et al. 2011. Tumor suppressive effects of psoriasin (S100A7) are mediated through α-catenin/TCF4 pathway in estrogen receptor positive breast cancer cells. Journal of Biological Chemistry, 286 (52):44845-54.

Z. Liu, X. Guo, C. Tan, J. Li, et al. Electron tunneling pathways and role of adenine in repair of cyclobutane pyrimidine dimer by DNA photolyase. 2012, Journal of American Chemistry Society, accepted

J. Li, et al. Applications of Vibrational Spectroscopy in the study of flavin-based photoactive proteins. 2011, Spectroscopy, Vol. 25, 261-269

Z. Liu, C. Tan, X. Guo, Y-T. Kao, J. Li, et al. Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase. 2011, Proceedings of the National Academy of Sciences of USA., vol. 108 no. 36 14831-14836

Zhongqi Ge, et al. Nuclear Hat1p Complex (NuB4) Components Participate in DNA Repair-linked Chromatin Reassembly, Journal of Biological Chemistry, May 13, 2011, 286, 16790-9

Nair, D. M., Ge, Z., et al. Genetic interactions between POB3 and the acetylation of newly synthesized histones, Curr Genet, 4, 271-86

Wang, H., Ge, Z., et al. The human histone chaperone sNASP interacts with linker and core histones through distinct mechanisms. Nucleic Acids Res, 40, 660-9

Eisfeld AK, et al. Heritable polymorphism predisposes to high BAALC expression in acute myeloid leukemia. Proc Natl Acad Sci USA. 2012 Apr 9. [Epub ahead of print]

Eisfeld AK, et al. miR-3151 interplays with its host gene BAALC and independently impacts on outcome of patients with cytogenetically normal acute myeloid leukemia. Blood First Edition Paper, prepublished online April 23, 2012; DOI 10.1182/ blood-2012-02-408492

William Blum, Sebastian Schwind, Somayeh S.Tarighat, Susan Geyer, Ann-Kathrin Eisfeld, et al. Clinical and pharmacodynamic activity of bortezomib and decitabinein acute myeloid leukemia. Accepted for publication in Blood April 6th 2012

Holpuch AS, Phelps MP, Desai KG, Chen W, Koutras GM, et al. Evaluation of a mucoadhesive fenretinide patch for local intraoral delivery: a strategy to reintroduce fenretinide for oral cancer chemoprevention. Carcinogenesis. 2012 May;33(5):1098-105. Epub 2012 Mar 15

Yali Zhu, Nil Celebi Cherukuri, Jamie N. Jackel, et al. (2012). Characterization of the RNA silencing suppression activity of the Ebola virus VP35 protein in plants and mammalian cells. Journal of Virology. doi:10.1128/JVI.05741-11

Xiuling Yang, Yan Xie, Priya Raja, Sizhun Li, Jamie N. Wolf, et al. (2011). Suppression of methylation-mediated transcriptional gene silencing by αC1-SAHH protein interaction drives geminivirus-DNA α satellite association. Plos Pathogens, 7, 10: e1002329

Ranganathan P, et al. Regulation of acute graft-versus-host disease by microRNA-155. Blood. 2012 Apr 4. [Epub ahead of print]

Ibhazehiebo, K., Iwasaki, T., Okano-Uchida, T., et al. (2011). Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6. Neurotoxicology. 32: 400-409

Cai, N., Kurachi, M., Shibasaki, K., Okano-Uchida, T., et al. (2012). CD44-Positive Cells Are Candidates for Astrocyte Precursor Cells in Developing Mouse Cerebellum. Cerebellum. 11:181-193

Sharma, A., et al. HIV-1 infection modifies the translational activity of infected lymphocytes: unexpected effects on eIF4E and CBP80 exchange. PLoS Pathogens 2012. 8(3): e1002612

Sharma, A., et al. Approaches to study the role of helicases in viral replication. Methods in Enzymology (Book Chapter) 2012. In press

Singh S, Janoos F, Pécot T, Caserta E, et al. Non-parametric population analysis of cellular phenotypes. Proceedings of the Medical Image and Computational Computer Assisted Intervention, 2011;14(Pt 2):343-51

Singh S, Janoos F, Pécot T, Caserta E, et al. Identifying nuclear phenotypes using semi-supervised metric learning. Proceedings of the Information Processing and Medical Imaging conference, 2011; 22:398-410

Pécot T, Singh S, Caserta E, et al. Non parametric cell nuclei segmentation based on a tracking over depth from 3D fluorescence confocal images. Proceedings of the International Symposium on Biomedical Imaging, to be published in May 2012

Ulm, E.A., et al. H.M. Developmental functions for the Caenorhabditis elegans sp protein SPTF-3. Mechanisms of Development 2011; 128:428-41

Zhou, C., et al. SPANosomes as delivery vehicles for small interfering RNA (siRNA). Mol Pharm, 9: 201-210, 2012

Zhang, Y. *, Zhou, C. *, et al. Efficient siRNA Delivery Using a Polyamidoamine Dendrimer with a Modified Pentaerythritol Core. Pharm Res, doi: 10.1007/s11095-012-0676-x., 2012

Zhou, C., et al. Synthesis and characterization of lipoidal aminebased nanocarrier formulations for small interfering RNA delivery. Therapeutic Delivery, 2012 (Accepted)

Alinari L; Mahoney E; Patton J; Zhang X; Huynh L; Earl CT; et al. FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death. Blood. 2011 Dec 22;118(5):6893-903

Xu Z, Chen YW, Battu A, et al. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. J Med Chem. 2011 Nov 10;54(21):7567-78. Epub 2011 Oct 12

Battu A, et al. ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation. Nucleic Acids Res. 2011 Oct;39(18):7931-45. Epub 2011 Jul 3

Tegla CA, Cudrici C, Rozycka M, Soloviova K, Ito T, Singh AK, et al. Rus H. C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation. Exp Mol Pathol. 2011 Aug;91(1):335-45. Epub 2011 Apr 22

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