Providing Tools for Discovery

The OSUCCC – James has contributed Pelotonia dollars to an Ohio State and state of Ohio investment in a significant upgrade and expansion of nuclear magnetic resonance (NMR) capabilities on Ohio State’s main campus.

Vicki Wysocki, PhD, an Ohio Eminent Scholar in the Department of Chemistry and Biochemistry in Ohio State’s College of Arts and Sciences, says several state-of-the-art instruments for measurements in both solution and solids were purchased and outfitted with a broad range of capabilities, including highfield superconducting magnets, cryogenically cooled measurement probes to optimize sensitivity, and sample robots for high-throughput applications.

“These capabilities are invaluable to cancer researchers at OSU as they will allow them to show the characterization at atomic detail of the structure and conformational dynamics of onco-proteins, their binding to small drugs and potential drug candidates, and the signature of changes in metabolic profiles in cancer during disease and treatment,” adds Rafael Bruschweiler, PhD, an Ohio Research Scholar with joint appointments in the Department of Chemistry and Biochemistry and in the College of Medicine at Ohio State.

Many of the new instruments are housed in Ohio State’s Campus Chemical Instrument Center (CCIC), which was founded in 1981 as a unit of the OSU Office of Research to provide research facilities for the entire campus in three areas: nuclear magnetic resonance, mass spectrometry and proteomics, and macromolecular X-ray crystallography.

“The CCIC is an interdisciplinary unit, servicing faculty from the colleges of Arts and Sciences; Education and Human Ecology; Engineering; Food, Agricultural and Environmental Sciences; Medicine; Optometry; Pharmacy; Veterinary Medicine; and Ohio State’s Comprehensive Cancer Center, to name a few,” Wysocki says.

She notes that the CCIC also is a hub for the Ohio NMR and Ohio MS Consortiums, providing researchers in colleges and universities throughout Ohio with access to all of the center’s facilities with on-campus user fees.

“In NMR, the existing 600 and 800 MHz instruments in the Riffe Building have recently been upgraded with new consoles, and a 700 MHz instrument has been installed in the same location as part of the overall upgrade,” Wysocki says, adding that installation of an 850 MHz instrument has begun in the new Chemical and Biomedical Engineering and Chemistry building, a second location of CCIC NMR. “That instrument will be joined by several other new instruments in the coming months.”

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