We Scan Solutions
The OSUCCC – James Digital Pathology team of experts is dedicated to building and implementing state-of-the-art tools and technologies that will help in detecting and diagnosing cancer accurately and quickly. Our team’s mission is to develop digital pathology tools to enable researchers, collaborators and expert physicians to find answers to research questions—simple and complex—using the most sophisticated technology available.
It Starts With the Scan
The digital pathology process begins with whole-slide imaging, or scanning conventional glass slides and then using leading technology to join consecutive images digitally into a single, whole image—replicating the information on the glass slide.
Using ultra-fast, high-capacity, whole-slide scanners from leading vendors, technicians can convert as many as 120 traditional glass slides into high-resolution digital images in less than two minutes. (source: Leica Biosystems)
Key features include:
- Superior image quality at 5-, 20- and 40-times magnification
- Adaptable to both 1” x 3” and 2” x 3” slides as well as immunofluorescent images
These enhanced images can be viewed and interpreted on a computer, and by multiple people across multiple locations simultaneously when needed.
- Convert glass slides to high-resolution digital images at 5-, 20-, and 40-times magnification
- Scan both standard 1” x 3” and 2” x 3” whole mount slides
- Scan immunofluorescent images
Digital Image Analysis
Once the image data is converted into millions of pixels and transferred (or hosted) onto specially designed desktop systems, the OSUCCC – James pathology specialists use Visiopharm Biotopix Digital Image Analysis (DIA) image analysis software to capture the biology that matters, quantify spatial and cellular relations, visualize clinically relevant patterns, and mine big data to uncover novel biomarker signatures. (source: Visiopharm)
What does this mean? The OSUCCC – James pathology experts can more accurately and quickly answer a multitude of questions about each patient’s diagnosis, enabling patients to receive personalized and potentially life-saving therapies even sooner.
Digital Image Analysis Services
The Digital Pathology Shared Resource uses VIS 7.0 software by Visiopharm. With this, the OSUCCC – James digital pathology experts can:
- Detect and precisely measure tissues, tumors or other desired morphologies
- Count and measure stained nuclei and categorize stain intensity
- Measure cytoplasmic staining and categorize stain intensity
- Measure, assess and quantify membrane staining and categorize stain intensity, completeness and more
- Count and measure cells
- Count and measure nuclei
- Count and measure vessels
- Count and measure spots
- Precisely quantify spatial relationships between stained cells and morphologic features
One of the key benefits of the OSUCCC – James Digital Pathology team’s expertise and platform (the way they obtain, store, analyze, convert and share cell information) is the ability to share and collaborate among numerous cancer specialists.
Using Leica’s Aperio eSlide Manager software, researchers—whether down the hall, in a different building or on opposite sides of the globe—can share and review images instantly, then assess and contribute valuable insights that ultimately lead to a more informed, more detailed diagnosis and personalized care plan for each patient.
Our internationally recognized teams of specialists and subspecialists span a broad range of disciplines, all specializing in cancer research, prevention, detection, treatment and cures. In fact, our physician experts help write the U.S. national clinical guidelines for treating specific cancers.
Our subspecialization and singular focus enable us to develop and deliver the most targeted therapies for each patient, leading to improved outcomes, faster responses, fewer side effects and more hope for cancer patients everywhere.
The Digital Pathology Shared Resource uses eSlide Manager software by Aperio-Leica. Our experts can:
- Host high-resolution images for viewing by collaborators virtually anywhere in the world
- Permit remote review and annotation by one or many collaborators
- Archive digital slide images, annotations and reviews for future use
- Provide Web-based service instantly and anywhere at any time.
Using Technology and Expertise to Predict Outcomes
The OSUCCC –James is implementing a long-term digital pathology solution for the cancer program as well as the overall health system, providing a safe, secure, permanent record of cell specimens and analysis. Doing so will enable our experts to compare and study a patient’s cancer progression, regression or other changes.
Not only will all new patient pathology slides be digitized, so also will those pathology slides that were processed over the past seven years at the OSUCCC – James.
That way, our pathology experts can easily access and review comprehensive information about a patient’s current diagnostic testing and results as well as information about previous testing and results. Then they can compare those outcomes with current information to develop the best individualized care plan for each patient.