Cancer is complex — there is no routine endometrial cancer, nor is there ever a routine way to treat it.

The OSUCCC – James physicians are nationally and internationally renowned in research and patient care for their one particular cancer. Because of that expertise and understanding of cancer’s complexities and how it acts and reacts differently in each person, the very best outcomes — and the most effective means of treating cancer patients — come from a team approach.

At the OSUCCC – James, endometrial cancer patients have a team of experts that includes medical gynecologic oncologists, surgical oncologists, radiation oncologists, geneticists, nutritionists and more. Also on that team are endometrial cancer researchers who help sequence tumors to identify key molecules that fuel each patient’s cancer and who then develop drugs that target only those particular molecules. Many of our experts also help write the national clinical guidelines for treatments.

As one of only a few cancer centers in the country funded by the National Cancer Institute to conduct both phase I and phase II clinical trials, the OSUCCC – James offers patients access to more clinical trials than nearly any other cancer hospital in the country and to more of the latest, most targeted, most effective treatment options — many that are available nowhere else but at the OSUCCC – James.

There are several types of treatment for endometrial cancer. The OSUCCC – James team of subspecialists determine the best treatment for each patient based on his or her specific, individual endometrial cancer. Patients may receive one treatment or a combination of treatments.

Treatment Options

The following treatments are available to treat endometrial cancer:


Surgery is the treatment chosen most often for endometrial cancer and may involve a total hysterectomy (removing the uterus and cervix), a bilateral salpingo-oophorectomy (surgery to remove both ovaries and both fallopian tubes) or a radical hysterectomy (surgery to remove the uterus, cervix and part of the vagina).

The ovaries, fallopian tubes or nearby lymph nodes may also be removed during a radical hysterectomy.

Even after the cancer is surgically removed, patients may undergo additional radiation or hormone treatment to kill any cancer cells that may have been missed. This lowers the risk of the cancer coming back.

Radiation Therapy

Radiation therapy uses X-rays to reach and destroy cancer cells. Radiation is often used to treat specific areas of the body.


Chemotherapy uses specialized drugs to stop the growth of cancer cells, either by destroying the cells or by preventing them from making new cells. The way the chemotherapy is given depends on the type and stage of the cancer being treated.

Hormone Therapy

Certain female sex hormones such as estrogens may in some cases cause endometrial cancer to grow. Hormone therapy uses drugs, surgery or radiation to stop or block hormones responsible for endometrial cancer. Hormone therapy alone will not cure endometrial cancer and over time it may stop working.


Immunotherapy is a treatment that uses the patient’s immune system to fight cancer. Substances made by the body, or made in a laboratory, can be used to encourage the body’s immune system to activate and attack endometrial cancer cells in the body.

Targeted Therapy

Targeted therapy is a type of drug treatment designed to attack cancer cells and leave healthy cells unharmed. These drugs tend to have less severe side effects and are usually more tolerated than chemotherapy drugs.

Several different types of targeted drugs are available to treat endometrial cancer. Some help constrict or stop blood vessels from forming in a tumor, serving to close off the nutrient supply to the tumor. Others work on the immune system by identifying and attacking certain substances on cancer cells.

Kinase inhibitors stop an important protein from working in cancer cells, causing them to die or stop growing.

(Source: National Cancer Institute )

Endometrial Cancer Research & Clinical Trials

For cancer patients, clinical trials mean hope. Hope for a cancer-free world and for better, more targeted ways to prevent, detect, treat and cure individual cancers.

Patients can enter clinical trials before, during or after starting their cancer treatment.

The OSUCCC – James has more than 500 open clinical trials at any given time, with some of the world’s latest discoveries available to clinical trial patients right here in Columbus, Ohio. In fact, patients have access to more cancer clinical trials here than at nearly any other hospital in the region as well as access to some of the most advanced, targeted treatments and drugs available.

The OSUCCC – James is one of only a few U.S. cancer centers funded by the National Cancer Institute (NCI) to conduct phase I and phase II clinical trials on novel anticancer drugs. These trials go only to centers that demonstrate an exemplary capacity for research and clinical care, the expertise to deliver the latest in treatments and the infrastructure to interpret and track treatment results.

Additionally, Ohio State has nearly 300 cancer researchers dedicated to understanding what makes each patient’s cancer grow, move, metastasize or reoccur. Because of the OSUCCC – James’ NCI phase I and phase II approvals, these experts can move research discoveries into clinical trials and make them available to patients sooner.

If you have received an endometrial cancer diagnosis, or if you want a second opinion or just want to speak to an endometrial cancer specialist, we are here to help you. Call 800-293-5066 or 614-293-5066 to make an appointment.

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The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue

Columbus, Ohio 43210

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