The world-renowned medical research experts at the OSUCCC – James are currently studying a number of different ways to detect Hodgkin’s lymphoma early so that treatment can begin as soon as possible, when options for treatment and cure are best.

Unlike some cancers, Hodgkin’s lymphoma has no screening test to help detect it, so the best way patients and doctors can work together to detect the disease is to know the risk factors and symptoms.

If you have received a Hodgkin’s lymphoma diagnosis, or if you want a second opinion or just want to speak to a lymphoma specialist, we are here to help you. Call 800-293-5066 or 614-293-5066 to make an appointment.

Diagnosing Hodgkin’s Lymphoma

Hodgkin’s lymphoma is most frequently diagnosed by a lymph node biopsy of an enlarged lymph node.

Evaluation of Hodgkin’s Lymphoma

If you are diagnosed with Hodgkin’s lymphoma symptoms, the OSUCCC – James experts will conduct an examination and often order a variety of blood tests, which may include:

Physical Exam

During a physical exam, your doctor will check for signs of Hodgkin’s lymphoma by examining general signs of health; discussing your health habits, past illnesses and previous treatments; and looking for anything unusual, such as swollen lymph nodes in the neck, underarm or groin.

Blood Tests

A blood test measures and counts the different types of cells in the blood.

A complete blood count, also called a CBC, lets the medical experts check for:

  • The number of red blood cells and platelets
  • The number and type of white blood cells
  • The amount of red blood cell hemoglobin, which is the protein that carries oxygen
  • The portion of the blood sample made up of red blood cells

Other blood tests may be done to measure the amount of certain chemicals and antibodies (proteins) in the blood. A peripheral blood smear is used to analyze how blood cells look under a microscope.

Blood Chemistry Studies

These tests measure the function of the liver and kidneys and will determine what type and how much chemotherapy a patient can safely receive.

Sedimentation Rate

This is a blood test that is a marker in the blood of inflammation. Some patients with Hodgkin’s lymphoma have an elevated sedimentation rate.

Bone Marrow Aspiration & Biopsy

After Hodgkin’s disease is confirmed, some patients may have a bone marrow aspiration and biopsy to determine if the lymphoma has spread to the bone marrow.

During a bone marrow aspiration, an OSUCCC – James specialist will insert a hollow needle into the hip bone or breastbone to remove a small sample of liquid bone marrow. For a bone marrow biopsy, a hollow needle will be inserted into the hip bone to collect a small sample of bone and marrow.

By studying blood and bone marrow samples, blood disorder specialists (called hematopathologists) can look for certain changes in the white blood cells, called lymphocytes.

Imaging Tests

The OSUCCC – James lymphoma specialists may use specialized X-rays or other imaging tests to help determine which lymph nodes are affected by Hodgkin’s lymphoma and if the disease has spread to other parts of the patient’s body.

Diagnostic medical imaging exams might include the following:

Computed Tomography (CT) Scanning

Use X-rays to capture cross-sectional images of the lymph nodes. Patients may need to have a dye injected into a vein to help highlight certain organs or tissues. For adult patients with Hodgkin’s lymphoma, CTs are used to examine the chest, neck, pelvis and abdomen.

Magnetic Resonance Imaging (MRI) Scans

Use powerful magnets to capture high-resolution images. MRIs can show excellent detail of certain areas inside the body, especially soft tissues.

Positron Emission Tomography (PET) Scans

A nuclear medicine technology that finds spots of cancer activity in the body. By injecting a small amount of radioactive glucose (sugar) into a vein, the scanner can capture images where the sugar collects and identify cancer cell activity. 


Some of these imaging tests, such as CT and PET, might also be used to see how well a patient’s cancer treatment is working.

(Source: National Cancer Institute)

Hodgkin’s Lymphoma Stages

Hodgkin’s lymphoma stages are:

Stage I

Hodgkin’s lymphoma in one lymph node area or one group of lymph nodes, for example, only lymph nodes in the left neck.

Stage II

Hodgkin’s lymphoma in two or more lymph node areas, either above or below the diaphragm. For example, lymph nodes that are enlarged in the R and L neck represent stage II Hodgkin’s lymphoma.

Stage III

Hodgkin’s lymphoma found in the lymph nodes or the spleen above and below the diaphragm.

Stage IV

Hodgkin’s lymphoma spread to the bone marrow, the bones, or to more than one organ (i.e. the lungs, the liver, etc).

(Source: National Cancer Institute)

If you have received a Hodgkin’s lymphoma diagnosis, or if you want a second opinion or just want to speak to a lymphoma specialist, we are here to help you. Call 800-293-5066 or 614-293-5066 to make an appointment.

Make an Appointment


Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator


Please enter a keyword (i.e. Name, Location) or choose a Cancer Type


Find a Location

Search by Building Name, Doctor Name, or ZIP code

The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue

Columbus, Ohio 43210

What to Expect at The James

Patient and Visitor's Guide

Get information about your stay, amenities, visitor information and more.

Your First Appointment

Know what to bring, how to prepare and what to expect at your first appointment.

Patient Education

Read from a library of resources designed by experts to help you answer questions and make informed decisions.

Contact Us