Cancer is complex — there is no routine neuroendocrine cancer, nor is there ever a routine way to treat it.

The OSUCCC – James physicians are nationally and internationally renowned in research and patient care for their one particular cancer. Because of that expertise and understanding of cancer’s complexities and how it acts and reacts differently in each person, the very best outcomes — and the most effective means of treating cancer patients — come from a team approach.

At the OSUCCC – James, neuroendocrine cancer patients have a team of experts that includes medical oncologists, surgical oncologists, radiation oncologists, geneticists, endocrinologists, nutritionists and more. Also on that team are neuroendocrine cancer researchers who help sequence tumors to identify key molecules that fuel each patient’s cancer and who then develop drugs that target only those particular molecules. Many of our experts also help write the national clinical guidelines for treatments.

As one of only a few cancer centers in the country funded by the National Cancer Institute to conduct both phase I and phase II clinical trials on novel anticancer drugs, the OSUCCC – James offers patients access to more clinical trials than nearly any other cancer hospital in the country and to more of the latest, most targeted, most effective treatment options — many that are available nowhere else but at the OSUCCC – James.

There are several types of treatment for neuroendocrine cancer. The OSUCCC – James team of subspecialists determine the best treatment for each patient based on his or her specific, individual neuroendocrine cancer. Patients may receive one treatment or a combination of treatments.


Surgery to remove the neuroendocrine tumor often is necessary to stop the tumor’s effects on hormone production. The doctor may remove all or part of the tumor. Types of surgery for neuroendocrine tumors often include:


The surgeon removes only the tumor. Enucleation is used especially for small and local neuroendocrine tumors.

Local Excision

The surgeon removes the tumor and some of the tissue around the tumor.


The surgeon removes part or all of the organ in which the neuroendocrine tumor is located. The surgeon also may remove nearby lymph nodes. Resection may have many different names, based on the organ being removed.


A special instrument freezes and destroys the cancerous tissue.

Radiofrequency Ablation

Using a special probe, the surgeon applies high-energy radio waves to the tissue to destroy cancer cells.

Radiation Therapy

Radiation therapy uses X-rays or other types of radiation to destroy cancer cells. Some neuroendocrine tumors are treated with a radioactive substance that is infused or delivered directly to the cancerous cells.


Chemotherapy uses drugs to stop the growth of cancer cells, either by destroying the cells or by stopping the cells from dividing. Chemotherapy may be given by mouth, injected into a vein or placed directly into an organ or body cavity.

Regional chemotherapy is delivered directly to the area in which a neuroendocrine tumor is located.

Hormone Therapy

Neuroendocrine cancers often are treated with hormone therapy alone, or along with other treatment, depending on the type and stage of disease.

Hormone therapy adds, blocks or removes hormones to stop the production of extra hormones and sometimes slows growth of tumors. The type of hormone therapy depends on the site of the tumor and hormone affected by the tumor.

Targeted Therapy

Targeted therapies use drugs and other substances to identify and attack specific cancer cells while sparing normal, healthy cells. Targeted therapies are used to treat several types of metastatic and recurrent neuroendocrine cancers.

Endocrine Biomarker 

(Source: National Cancer Institute)

Clinical Trials

Many patients with neuroendocrine cancer opt for new therapies being investigated in clinical trials

If you have received a neuroendocrine cancer diagnosis, or if you want a second opinion or just want to speak to a neuroendocrine cancer specialist, we are here to help you. Call 800-293-5066 or 614-293-5066 to make an appointment.

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The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue

Columbus, Ohio 43210

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