The nationally recognized subspecialists at the OSUCCC – James believe the best way to treat patients and manage their disease successfully is to deliver the latest, most effective treatments available and to work with nationally and internationally renowned experts to develop the newest and best non-Hodgkin’s lymphoma (NHL) treatments and programs.

Because these renowned subspecialists understand that NHL is a complex disease, they use the most effective means of treating patients through an expert team approach from across multiple medical disciplines. These teams also run groundbreaking studies, and through detailed observations, evaluate the latest treatments and targeted therapies. 

If you’ve been diagnosed with non-Hodgkin’s lymphoma, would like a second opinion or would like to speak with a lymphoma specialist, please call The James Line at 800-293-5066 or 614-293-5066 to make an appointment.

Treatment Options

Treatment for Non-Hodgkin’s lymphoma depends on all of the following: 

  • The type of NHL 
  • The patient’s age and general health
  • If the NHL was just diagnosed or if it has come back
  • The stage of the cancer

The OSUCCC – James team of experts will recommend one or more of the following treatments, based on your individual needs, to manage your NHL:


Chemotherapy, which destroys cancer cells or stops them from dividing, is the treatment plan most often prescribed for B-cell or T-cell NHL patients.

Chemotherapy drugs can be taken by mouth or injected into a vein or muscle.

Chemotherapy treatments may take place in the clinic or in the hospital, depending on the type of chemotherapy drugs utilized.

Radiation Therapy

Radiation therapy uses high-energy X-rays or other radiation to kill cancer cells or keep them from growing.

The OSUCCC – James radiation specialists are leaders in innovative radiation treatments, including conformal imaging-based radiation therapy, intensity-modulated radiation therapy (IMRT), total-body radiation therapy, total-skin electron beam therapy, stereotactic radiosurgery and using a Varian TrueBeam Linear Accelerator


Immunotherapy, also called biologic therapy, interacts with a patient's immune system to fight cancer. Substances made by the body or in a laboratory are used to direct or restore the body's natural defenses against cancer. Treatments for B-cell NHL often include monoclonal antibodies like rituximab that improve the effectiveness of chemotherapy.

Stem Cell Transplantation

Stem cell transplants enable patients to receive chemotherapy therapy treatment and then later replace blood-forming cells that have been destroyed by cancer treatment.

Stem cells, which are immature blood cells, are removed from the blood or bone marrow of either the patient or a donor, and then they are frozen and stored. After chemotherapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into and restore the body's blood cells.

If a stem cell transplant is needed, the OSUCCC – James has one of the most active, sophisticated programs in the entire nation.

(Source: National Cancer Institute)

Non-Hodgkin’s Lymphoma Research & Clinical Trials

For lymphoma patients, clinical trials mean hope.

The OSUCCC – James has hundreds of open clinical trials at any given time, with some of the world’s latest discoveries available to clinical trial patients right here in Columbus, Ohio. Typically 10-12 trials for patients with various types of non-Hodgkin’s lymphoma are available at any one time at the OSUCCC – James. In fact, patients have access to more cancer clinical trials here than at nearly any other hospital in the region as well as access to some of the most advanced, targeted treatments and drugs available.  

Who Should Participate in a Clinical Trial?

Patients can enter clinical trials before, during or after starting their individual treatments.

The OSUCCC – James is one of only a few U.S. cancer centers funded by the National Cancer Institute to conduct phase I and phase II clinical trials on novel anticancer drugs.

These trials go only to centers that demonstrate an exemplary capacity for research and clinical care, the expertise to deliver the latest in treatments and the infrastructure to interpret and track treatment results.

If you’ve been diagnosed with non-Hodgkin’s lymphoma, would like a second opinion or would like to speak with a lymphoma specialist, please call The James Line at 800-293-5066 or 614-293-5066 to make an appointment.

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The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue

Columbus, Ohio 43210