Cancer is complex — there is no routine peritoneal cancer, nor is there ever a routine way to treat it.

The OSUCCC – James peritoneal cancer specialists and subspecialists are nationally and internationally renowned in research and patient care for their one particular cancer. In fact, our physician experts actually help write the national clinical guidelines for treating specific cancers. Because of that expertise and understanding of cancer’s complexities and how it acts and reacts differently in each person, the very best outcomes — and the most effective means of treating cancer patients — come from a team approach.

At the OSUCCC – James, the peritoneal cancer treatment team includes internationally recognized gynecologic and gastrointestinal medical oncologists, surgical oncologists, radiation oncologists, geneticists, nutritionists and more. Also on that team are peritoneal cancer researchers who help sequence tumors to identify key molecules that fuel each patient’s cancer and who then develop drugs that target only those particular molecules. Working together and across medical disciplines, this super subspecialized team develops individualized, highly targeted treatment plans that specifically target the molecular and biological makeup of your individual cancer.

As one of only a few cancer centers in the country funded by the National Cancer Institute to conduct both phase I and phase II clinical trials, the OSUCCC – James offers patients access to more clinical trials than nearly any other cancer hospital in the region and more of the most targeted, most effective treatment options, many of which are available only at the OSUCCC – James.

Peritoneal Cancer Treatment

As a National Cancer Institute (NCI)–designated comprehensive cancer center, the OSUCCC — James offers patients access to novel therapies that may not be available anywhere else in the United States. The James also leads some of the world’s most advanced, sophisticated clinical trials for peritoneal cancer.

Every person’s disease is different, with individually unique genes and molecules driving that disorder. At the OSUCCC – James, our peritoneal cancer subspecialists are world-renowned experts who focus solely on gynecologic and gastrointestinal disorders and who reach across medical disciplines to design the very best treatment plan and therapies to target each patient’s specific cancer.

One or more of the following treatments may be recommended.

Patients may also benefit from new therapies available in clinical trials.


Not all peritoneal cancer patients may require surgery. Your OSUCCC – James experts will recommend surgery only if it is beneficial.

Only a few hospitals in the country perform as many peritoneal surgeries as the OSUCCC — James specialists perform each year, lending to its nationally and internationally renowned expertise.

Radiation Therapy

Radiation therapy is used in selective cases of peritoneal cancers.

Radiation therapy uses high-energy X-rays or other types of radiation targeted directly at the cancer cells to destroy those cells or keep them from growing.

The radiation is aimed at the cancer from outside the body or delivered to the cancer inside the body through tiny seeds that are usually directed to the organ using catheters, or thin tubes.

A patient with peritoneal cancer may receive radiation therapy before or after a surgery to remove tissue or a tumor. Radiation can shrink a tumor to make surgery more successful, and it is delivered only to the tumor in order to prevent damage to surrounding, healthy tissue.


Chemotherapy drugs stop cancer cell growth by either destroying the cells or stopping them from dividing and making new cells.

Chemotherapy drugs can be taken by mouth or injected into a vein or muscle, and they may be given over a period of months.

When the drugs enter the bloodstream, they can reach cancer cells throughout the body (called systemic chemotherapy). Combination chemotherapy uses more than one anti-cancer drug.

A low-dose chemotherapy is often given while a patient is also undergoing external radiation therapy.

HIPEC Therapy

Hyperthermic intraperitoneal chemotherapy (HIPEC) treatment where a concentrated amount of chemotherapy is delivered to the abdomen during surgery. The OSUCCC – James is one of the select centers in the country to perform this procedure.

Targeted Therapies

Targeted therapies are drugs that target and attack cancer cells without destroying healthy surrounding cells. These drugs sometimes have less severe side effects than other treatments, including standard chemotherapy drugs delivered alone. And sometimes, by delivering these drugs in combination with chemotherapy, targeted therapies interrupt certain proteins and receptors to stop cancer cells from growing.


Immunotherapy, also called biologic therapy, boosts a patient's immune system to fight cancer. Substances made by the body or made in a laboratory are used to direct or restore the body's natural defenses against cancer.

Treatments can include treating patients with proteins that block tumor growth (called monoclonal antibodies) and vaccines.

Peritoneal Cancer Research & Clinical Trials

For cancer patients, clinical trials mean hope. Hope for a cancer-free world and for better, more targeted ways to prevent, detect, treat and cure individual cancers.

Patients can enter clinical trials before, during or after starting their cancer treatment.

The internationally recognized experts at the OSUCCC – James believe the best way to treat patients and manage their disease successfully is to be at the forefront of delivering the latest, most effective treatments available and by working with nationally and internationally renowned experts to develop the newest and best peritoneal cancer treatments and programs.

The OSUCCC – James has more than 500 open clinical trials at any given time, with some of the world’s latest discoveries available to clinical trial patients right here in Columbus, Ohio. In fact, patients have access to more of this nation’s leading-edge, targeted treatments and cancer clinical trials here than at nearly any other hospital in the region as well as access to some of the most advanced, targeted treatments and drugs.

Additionally, the OSUCCC – James is one of only a few U.S. cancer centers funded by the National Cancer Institute (NCI) to conduct phase I and phase II clinical trials. These trials go only to centers that demonstrate an exemplary capacity for research and clinical care, the expertise to deliver the latest in treatments and the infrastructure to interpret and track treatment results.

The OSUCCC – James and Ohio State have nearly 300 cancer researcher scientists dedicated to understanding what makes each patient’s cancer grow, spread or reoccur. And because of the OSUCCC – James’ NCI phase I and phase II approvals, these experts can move research discoveries into clinical trials and get them to patients sooner, which can mean improved outcomes, faster responses and fewer side effects.

If you’ve been diagnosed with peritoneal cancer, would like a second opinion or would like to speak with a peritoneal cancer specialist, please call The James Line at 800-293-5066 or 614-293-5066 to make an appointment.

Who Should Participate in a Clinical Trial

For some patients, taking part in a clinical trial may be the best treatment choice. Patients can enter clinical trials before, during or after starting their cancer treatment.

The OSUCCC – James is one of only a few institutions funded by the National Cancer Institute (NCI) to conduct phase I and II clinical trials on NCI–sponsored anticancer drugs.

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The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue

Columbus, Ohio 43210

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