Clinical Trials

The James Cancer Center Columbus, OH

open for enrollment

Open-Label, Dose-Escalation Study of INCB054828 in Subjects With Advanced Malignancies

Protocol: OSU-15241

Full Title

A Phase I/II, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB054828 in Subjects With Advanced Malignancies

Purpose

The purpose of this study will be to evaluate the safety, tolerability, and pharmacological

activity of INCB054828 in subjects with advanced malignancies. This study will have three

parts, dose escalation (Part 1), dose expansion (Part 2) and combination therapy (Part 3).

Are you eligible?

Inclusion Criteria:

Inclusion Criteria:

1. Male or female subjects, age 18 years or older on day of signing consent

2. Part 1: Any advanced solid tumor malignancy; Part 2: Subjects with squamous non-small

cell lung cancer, cholangiocarcinoma/gastric cancer, urothelial cancer,

breast/endometrial cancer, multiple myeloma, or MPNs that have a tumor or malignancy

that has been evaluated and confirmed to harbor genetic alterations in FGF or FGFR

genes. A subject's fibroblast growth factor (FGF) or fibroblast growth factor

receptor (FGFR) alteration may be based on local or central laboratory results. Part

3: Dose finding: subjects with solid tumor malignancies who qualify for combo

therapy; dose-expansion: FGF/FGFR+ subjects qualified to receive combo therapy

3. Has progressed after prior therapy and there is no further effective standard

anticancer therapy available (including subject refuses or is intolerant)

4. Life expectancy > 12 weeks

5. Eastern Cooperative Oncology Group (ECOG) performance status:

Part 1: 0 or 1

Part 2 and 3: 0, 1, or 2

Exclusion Criteria:

1. Treatment with other investigational study drug for any indication for any reason, or

receipt of anticancer medications within 21 days or 5 half-lives before first dose of

study drug

2. Prior receipt of a selective FGFR inhibitor

3. History of a calcium/phosphate homeostasis disorder

4. History and/or current evidence of ectopic mineralization/calcification

5. Current evidence of corneal disorder/keratopathy

6. Has a history or presence of inadequate liver, renal, hematopoietic and/or cardiac

function parameters outside protocol-defined range

7. Prior radiotherapy within 2 weeks of study treatment

Exclusion Criteria:

Inclusion Criteria:

1. Male or female subjects, age 18 years or older on day of signing consent

2. Part 1: Any advanced solid tumor malignancy; Part 2: Subjects with squamous non-small

cell lung cancer, cholangiocarcinoma/gastric cancer, urothelial cancer,

breast/endometrial cancer, multiple myeloma, or MPNs that have a tumor or malignancy

that has been evaluated and confirmed to harbor genetic alterations in FGF or FGFR

genes. A subject's fibroblast growth factor (FGF) or fibroblast growth factor

receptor (FGFR) alteration may be based on local or central laboratory results. Part

3: Dose finding: subjects with solid tumor malignancies who qualify for combo

therapy; dose-expansion: FGF/FGFR+ subjects qualified to receive combo therapy

3. Has progressed after prior therapy and there is no further effective standard

anticancer therapy available (including subject refuses or is intolerant)

4. Life expectancy > 12 weeks

5. Eastern Cooperative Oncology Group (ECOG) performance status:

Part 1: 0 or 1

Part 2 and 3: 0, 1, or 2

Exclusion Criteria:

1. Treatment with other investigational study drug for any indication for any reason, or

receipt of anticancer medications within 21 days or 5 half-lives before first dose of

study drug

2. Prior receipt of a selective FGFR inhibitor

3. History of a calcium/phosphate homeostasis disorder

4. History and/or current evidence of ectopic mineralization/calcification

5. Current evidence of corneal disorder/keratopathy

6. Has a history or presence of inadequate liver, renal, hematopoietic and/or cardiac

function parameters outside protocol-defined range

7. Prior radiotherapy within 2 weeks of study treatment

Lung Cancers Bladder Cancer Stomach (Gastric) Cancer Multiple Myeloma Gynecologic Cancers Breast Cancer Liver Cancer