Clinical Trials

The James Cancer Center Columbus, OH

open for enrollment

Optimal Sequencing of Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in First-Line NSCLC

Protocol: OSU-16074

Full Title

Randomized Phase II Trial Evaluating the Optimal Sequencing of PD-1 Inhibition with Pembrolizumab (MK-3475) and Standard Platinum-based Chemotherapy in Patients with Chemotherapy naive stage IV Non-small Cell Lung Cancer

Purpose

This is a multicenter randomized phase II to determine if the administration of standard

platinum-based chemotherapy before MK-3475 in with Chemotherapy naive stage IV Non-small

Cell Lung Cancer (NSCLC) will improve the overall response rate (ORR) compared to MK-3475

administered before chemotherapy. Patients will be given Pembrolizumab as maintenance up to

1 year: Carboplatin and paclitaxel or pemetrexed every 3 weeks x 4 cycles followed by

pembrolizumab every 3 weeks for up to 1 year. Pembrolizumab every 3 weeks x 4 cycles

followed by carboplatin and paclitaxel or pemetrexed every 3 weeks x 4 cycles followed by

pembrolizumab every 3 weeks for up to 1 year.

Study Objective

While a genotype-directed strategy has been established as effective in treatment selection

for patients with advanced NSCLC, only a minority of patients at this time will have a

readily identifiable actionable molecular target. Furthermore, genotype-directed therapy has

not been validated for patients with squamous cell carcinoma of the lung. Therefore, the

majority of patients with advanced NSCLC will continue to rely on standard platinum-based

doublet chemotherapy. Given the plateau in effectiveness of this approach, novel treatment

strategies are clearly warranted.

Are you eligible?

Inclusion Criteria:

Inclusion Criteria:

1. Be ≥ 18 years of age on day of signing informed consent.

2. Have a life expectancy of at least 3 months.

3. Have a histologically or cytologically confirmed diagnosis of stage IV NSCLC.

4. Have a performance status of 0 or 1 on the ECOG.

5. Have a measurable disease based on RECIST 1.1.

6. Have provided tissue from an archival tissue sample or newly obtained core or

excisional biopsy of tumor lesion.

7. In patients with non-squamous non-small cell lung cancer, investigators must be able

to produce source documentation of the EGFR mutation status or ALK translocation

status.

8. Demonstrate adequate organ function.

9. Female patient of childbearing potential should have a negative urine or serum

pregnancy test within 72 hours.

10. Female parents of childbearing potential must be willing to use 2 methods of birth

control or be surgically sterile.

11. Male patients must agree to use an adequate method of contraception.

Exclusion Criteria:

1. Has received prior treatment with chemotherapy or biologic therapy for stage IV

NSCLC.

2. Is currently participating in or has participated in a study of an investigational

agent or using an investigational device.

3. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any

other form of immunosuppressive therapy.

4. Has had a prior mAb within 4 weeks prior to study Day 1 or who has not recovered from

adverse events due to agents administered more than 4 weeks earlier.

5. Has had prior chemotherapy or radiation.

6. Has a known additional malignancy that is progressing or requires active treatment.

7. Has known active CNS metastases and/or carcinomatous meningitis.

8. Has an active autoimmune disease requiring systemic treatment within the past 3

months or a documented history of clinically severe autoimmune disease, or a syndrome

that requires systemic steroids or immunosuppressive agents.

9. Has evidence of interstitial lung disease or active, non-infectious pneumonitis.

10. Has an active infection requiring systemic therapy.

11. Has a history or current evidence of any condition, therapy, or laboratory

abnormality that might confound the results of the trial.

12. Has known psychiatric or substance abuse disorders.

13. Is pregnant or breastfeeding, or expecting to conceive or father children within the

projected duration of the trial.

14. Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or

CTLA-4 antibody.

15. Has a known history of HIV.

16. Has known active Hepatitis B or Hepatitis C.

17. Has received a live vaccine within 30 days prior to the planned first dose of study

therapy.

18. Has a known history of active TB.

19. Hypersensitivity to pembrolizumab or any of it's excipients.

Exclusion Criteria:

Inclusion Criteria:

1. Be ≥ 18 years of age on day of signing informed consent.

2. Have a life expectancy of at least 3 months.

3. Have a histologically or cytologically confirmed diagnosis of stage IV NSCLC.

4. Have a performance status of 0 or 1 on the ECOG.

5. Have a measurable disease based on RECIST 1.1.

6. Have provided tissue from an archival tissue sample or newly obtained core or

excisional biopsy of tumor lesion.

7. In patients with non-squamous non-small cell lung cancer, investigators must be able

to produce source documentation of the EGFR mutation status or ALK translocation

status.

8. Demonstrate adequate organ function.

9. Female patient of childbearing potential should have a negative urine or serum

pregnancy test within 72 hours.

10. Female parents of childbearing potential must be willing to use 2 methods of birth

control or be surgically sterile.

11. Male patients must agree to use an adequate method of contraception.

Exclusion Criteria:

1. Has received prior treatment with chemotherapy or biologic therapy for stage IV

NSCLC.

2. Is currently participating in or has participated in a study of an investigational

agent or using an investigational device.

3. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any

other form of immunosuppressive therapy.

4. Has had a prior mAb within 4 weeks prior to study Day 1 or who has not recovered from

adverse events due to agents administered more than 4 weeks earlier.

5. Has had prior chemotherapy or radiation.

6. Has a known additional malignancy that is progressing or requires active treatment.

7. Has known active CNS metastases and/or carcinomatous meningitis.

8. Has an active autoimmune disease requiring systemic treatment within the past 3

months or a documented history of clinically severe autoimmune disease, or a syndrome

that requires systemic steroids or immunosuppressive agents.

9. Has evidence of interstitial lung disease or active, non-infectious pneumonitis.

10. Has an active infection requiring systemic therapy.

11. Has a history or current evidence of any condition, therapy, or laboratory

abnormality that might confound the results of the trial.

12. Has known psychiatric or substance abuse disorders.

13. Is pregnant or breastfeeding, or expecting to conceive or father children within the

projected duration of the trial.

14. Has received prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or

CTLA-4 antibody.

15. Has a known history of HIV.

16. Has known active Hepatitis B or Hepatitis C.

17. Has received a live vaccine within 30 days prior to the planned first dose of study

therapy.

18. Has a known history of active TB.

19. Hypersensitivity to pembrolizumab or any of it's excipients.

Lung Cancers