David O'Malley, MD

The James Cancer Center
David O'Malley

Clinical Expertise

  • Cervical Cancer
  • Endometrial Cancers
  • Gynecologic Cancers
  • Gynecologic Oncology
  • Minimally Invasive Surgical Procedures
  • Ovarian Cancers
  • Peritoneal Cancers
  • Reproductive Health
  • Robotics
  • Soft Tissue Cancers
  • Uterine Cancers
  • Vaginal Cancers
  • Vulvar Cancers
  • Women's Health
Insurance Information



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I am a gynecologic oncologist and professor in the Department of Obstetrics and Gynecology at The Ohio State University Wexner Medical Center. I have been on the Ohio State faculty since 2005.

I earned my medical degree from Wayne State University School of Medicine, completed my residency at Case Western Reserve University (MetroHealth) and the Cleveland Clinic Foundation, and my fellowship at Yale University.

I am actively involved in improving the quality of patient care, safety and satisfaction. I serve as the chair of The James Committee on Patient Satisfaction and am a member of the Patient Experience Counsel, the Perioperative Quality Management Committee and The James Quality and Patient Safety Committee.

I am active nationally as a member of the Marketing and Communication Committee of the Society of Gynecologic Oncologists (SGO) and the Ovarian Cancer, Developmental Therapeutics and Membership Committees of the Gynecologic Oncology Group (GOG). I was appointed to the panel of the National Comprehensive Cancer Network (NCCN) Guidelines for Ovarian Cancer. Most recently, I accepted the invitation to be one of three U.S. members of the steering committee for TRINOVA 3, a multinational phase III ovarian cancer trial.

My drive to have no patient with a gynecologic cancer succumb to the disease guides my research that specializes in the development of therapeutics/treatments for gynecologic cancers, concentrating on ovarian and uterine (endometrial). I have designed, coordinated and published on phase I, II and III clinical trials with a special interest in compounds that effect angiogenesis. This led to becoming the institutional principal investigator for the NCCN Ovarian Cancer Outcomes Project. Improving patient treatment options cannot be accomplished without understanding how the treatments are having an effect at the cellular level; therefore, I continue to participate in projects that help define these mechanisms. I work to improve not only the therapies (chemotherapy) but to identify patients that would benefit (or not benefit) from adjuvant therapeutic options in ovarian and uterine cancer (specifically high risk histologies) patients.

My quest to improve patient outcomes has led to working on improving surgical techniques. I have implemented robotic assisted minimally invasive surgical techniques in all aspects of practice, and published the improved outcomes of these techniques. I have collaborated across multiple medical specialties to identify ways to improve the technique and outcomes of how malignant cells are removed at the time of surgery (Ramen spectroscopy). My team has submitted and been awarded grants to study these techniques and my research has been recognized with more than 50 publications.

I was named to the Castle Connolly list of “Regional Top Doctors” from 2011-2018 and was rated in the top 10 percent of physicians in the nation for patient satisfaction in 2017.

Education and Background


  • Wayne State University School of Medicine

    Detroit, MI


  • OB/GYN / Gynecological Oncology

    Yale University School of Medicine

    New Haven, CT

Board Certifications

  • American Board of OB/GYN
  • American Board of OB/GYN (Subspecialty: Gynecologic Oncology)

Academic Department

I see patients at

JamesCare Gynecologic Oncology at Mill Run

3651 Ridge Mill Drive, Hilliard, Ohio 43026


Stefanie Spielman Comprehensive Breast Center

1145 Olentangy River Road, Columbus, Ohio 43212


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 3/26/2018, Dr. O'Malley has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office at 614-293-7802.

  • Amgen, Inc.
  • AstraZeneca
  • Clovis Oncology
  • Tesaro, Inc.


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