Don Benson, MD, PhD

The James Cancer Center
Don Benson

Clinical Expertise

  • Amyloidosis
  • Blood Cancers
  • Bone Marrow Transplantation
  • Hematology
  • Lymphomas
  • Multiple Myeloma
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I’m an oncologist and hematologist caring for patients with multiple myeloma, amyloidosis and other blood cancers. I’m also actively involved in clinical and laboratory-based research to develop new treatments and approaches to these conditions. I serve as an associate professor of clinical internal medicine for The Ohio State University and as Head of Translational Research in the division of hematology at the OSU Wexner Medical Center. In 2014 and 2017, I was rated in the top 10 percent of physicians in the nation for patient satisfaction.

We strive to deliver personalized care to our patients by taking into account not only their specific type of cancer but their desires and goals as well. Our research programs work toward developing novel treatments that harness and enhance the immune system’s ability to detect and kill cancer cells. Natural killer cells are a type of immune cell capable of eliminating cancer cells. Much of the research we do focuses on augmenting or recovering the function of these cells.

I’ve published 87 peer-reviewed clinical, translational and laboratory based research papers in journals such as Journal of Clinical Oncology, Blood, PNAS, Cancer Cell, Clinical Cancer Research and many others. My team’s work has been presented at international scientific meetings around the world, and has been funded by the National Cancer Institute, the American Cancer Society, Pelotonia and other sources.

I feel blessed to work at The James because of my team. I believe that the collective care we provide to patients is much greater than our individual contributions. Our patients have the added benefit of the entire institution supporting them in their fight to overcome cancer.

Education and Background


  • Northeastern Ohio Universities College of Medicine

    Rootstown, OH


  • Hematology/Oncology

    Ohio State University Wexner Medical Center

    Columbus, OH

Board Certifications

  • American Board of Internal Medicine
  • American Board of Internal Medicine (Subspecialty: Medicine Oncology)

Academic Department

I see patients at

The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue, Columbus, Ohio 43210


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 3/26/2018, Dr. Benson has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office at 614-293-7802.

  • Columbus Community Clinical Oncology Program
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