Don Benson, MD, PhD

The James Cancer Center
Don Benson

A physician, or doctor, is extensively trained to diagnose and treat complex medical problems. Often, physicians focus their practice on certain disease categories, treatment methods or patient types. Physicians can diagnose and treat illness, prescribe medication, offer medical consultation and advice, perform surgery and more.


  • Hematology

Clinical Expertise

  • Bone Marrow Transplantation
  • Multiple Myeloma
  • Amyloidosis
  • Blood Cancers
Insurance Information



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I’m a hematologist/oncologist caring for patients with multiple myeloma, amyloidosis and those undergoing blood and marrow transplantation. I am privileged to lead clinical trials and research projects in my laboratory to develop new treatments for and understanding of these conditions. I am grateful to teach in The Ohio State University College of Medicine, where I have received both the Professor of the Year Award (2012) and the Distinguished Educator Award (2015). I currently serve as a professor of medicine and as the director of the Myeloma Program, as well as the interim director of the Division of Hematology, Department of Internal Medicine at The Ohio State University. For many years, I have been recognized as being in the top 10 percent of physicians in the nation for patient satisfaction.

We strive to deliver personalized care to our patients by taking into account not only their specific type of cancer but their desires and goals as well. My team’s research programs work toward developing novel treatments that enhance the immune system’s ability to detect and kill cancer cells. Natural killer cells are a type of immune cell capable of eliminating cancer cells, and much of the research we do focuses in the exciting area of immunotherapy for cancer.

I’ve published over 100 peer-reviewed clinical, translational and laboratory-based research papers in journals such as Journal of Clinical Oncology, Blood, PNAS, Cancer Cell, Clinical Cancer Research and others. My team’s work has been presented at international scientific meetings around the world and has been funded by the National Cancer Institute, the American Cancer Society, Pelotonia and other sources.

I feel blessed to work at The James because of my team. I believe that the collective care we provide to patients is much greater than our individual contributions. Our patients have the added benefit of the entire institution supporting them in their fight to overcome cancer.

Education and Background


  • Northeastern Ohio Universities College of Medicine

    Rootstown, OH


  • University of Virginia Health System

    Charlottesville, VA


  • Hematology/Oncology

    Ohio State University Wexner Medical Center

    Columbus, OH

Board Certifications

  • American Board of Internal Medicine
  • American Board of Internal Medicine (Subspecialty: Medicine Oncology)

Academic Department

I see patients at

The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue, Columbus, Ohio 43210


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 12/20/2018, Dr. Benson has reported no relationships with companies or entities.


Clinical Trials | Lead

  • OSU-17279

  • OSU-19036

  • OSU-17144

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