Lawrence Shirley, MD

The James Cancer Center
Lawrence Shirley

A physician, or doctor, is extensively trained to diagnose and treat complex medical problems. Often, physicians focus their practice on certain disease categories, treatment methods or patient types. Physicians can diagnose and treat illness, prescribe medication, offer medical consultation and advice, perform surgery and more.


  • Surgical Oncology

Clinical Expertise

  • Thyroid Diseases
  • Adrenal Gland Cancers
  • Neuroendocrine Tumors
  • Thyroid Cancer
  • Endocrine Cancers
  • Parathyroid Diseases
  • Parathyroid Cancers
  • Adrenocortical Adenoma
  • Adrenocortical Carcinoma
Insurance Information



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I’m a surgical oncologist with a focus on endocrine cancers, specifically tumors of the thyroid, parathyroid and adrenal glands. I enjoy the spectrum of patient care, from removing tumors in patients who go back to living normal, productive lives, to treating those with widespread cancer who could have improved quality of life with surgical treatment.

In dealing with patients who have lesions within the thyroid, traditionally we have been uncertain which should be removed and which can be observed. At the OSUCCC – James, we use the latest technology to help make this determination so that we can safely remove some cancers while keeping other patients from unnecessary procedures.

Once patients have a diagnosis of cancer, I’m able to collaborate with my colleagues to make sure these patients have the most cutting-edge treatments. My research interests include the development of novel therapeutics for aggressive thyroid cancer, and determining the role of a tumor’s microenvironment in thyroid cancer progression.

I also serve as an assistant professor for surgical oncology for The Ohio State University College of Medicine, and have co-authored many articles in such journals as Cancer Research, Journal of Surgical Oncology and Journal Of Medicine And Biomedical Sciences.

There is no greater honor than being able to practice alongside some of the most renowned cancer experts in the world. Beyond this, there’s a wonderful camaraderie among my colleagues. We’re all focused on one goal – creating a cancer-free world.

Education and Background


  • University of Kentucky College of Medicine

    Lexington, KY


  • Thomas Jefferson University Hospital

    Philadelphia, PA


  • Surgical Oncology

    Ohio State University Wexner Medical Center

    Columbus, OH

Board Certifications

  • American Board of Surgery

Academic Department

  • Department of Surgery
  • Division of Surgical Oncology

I see patients at

The James at Martha Morehouse Outpatient Care

2050 Kenny Road, Columbus, Ohio 43221


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 12/20/2018, Dr. Shirley has reported no relationships with companies or entities.


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