Matthew Old, MD

The James Cancer Center
Matthew Old

A physician, or doctor, is extensively trained to diagnose and treat complex medical problems. Often, physicians focus their practice on certain disease categories, treatment methods or patient types. Physicians can diagnose and treat illness, prescribe medication, offer medical consultation and advice, perform surgery and more.


  • Otolaryngology

Clinical Expertise

  • Lip Cancers
  • Melanoma
  • Skin Cancers
  • Head and Neck Cancer
  • Skull Base Tumors
  • Thyroid Cancer
  • Parathyroid Cancers
  • Salivary Gland Cancers
  • Facial Cancers
  • Bell Palsy
  • Carotid Body Tumor
  • Ear Cancer
  • Esophageal Cancers
  • Facial Nerve Diseases
  • Facial Paralysis
  • Goiter, Endemic
  • Goiter, Nodular
  • Goiter, Substernal
  • Graves Disease
  • Hyperparathyroidism, Primary
  • Hyperparathyroidism, Secondary
  • Jaw Diseases
  • Jaw Cancers
  • Laryngeal Diseases
  • Laryngostenosis
  • Laryngeal Cancers
  • Lichen Planus, Oral
  • Lingual Goiter
  • Mandibular Diseases
  • Maxillary Diseases
  • Maxillofacial Injuries
  • Microvessels
  • Mouth Diseases
  • Mouth Cancers
  • Multiple Endocrine Neoplasia Type 1
  • Multiple Endocrine Neoplasia Type 2a
  • Multiple Endocrine Neoplasia Type 2b
  • Oropharyngeal Cancers
  • Otorhinolaryngeal Cancer
  • Nose Diseases
  • Nose Cancers
  • Parathyroid Diseases
  • Pharyngeal Diseases
  • Pharyngeal Cancers
  • Thyroid Diseases
  • Thyroid Dysgenesis
  • Tracheal Tumors
  • Tracheal Stenosis
  • Zenker Diverticulum
Insurance Information



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I’m an associate professor and director of the Department of Otolaryngology - Head and Neck Surgery. I was named to the Castle Connolly list of "Regional Top Doctors" from 2015-2018 and was also rated in the top 10 percent of physicians in the nation for patient satisfaction in 2017.

I graduated with honors from Stanford University with a degree in Human Biology and received my MD from the University of Texas-Houston Medical School. After finishing residency at the University of Michigan, I completed a Cranial Base, Microvascular Reconstruction, and Head and Neck Surgery Fellowship at Vanderbilt University in Nashville, TN. I was proud to receive many notable academic achievement awards during my education, as well as being a member of Stanford’s NCAA and PAC-10 championship men’s swimming team.

I am currently an active member of the American Academy of Otolaryngology, specifically the Head and Neck Education Committee, which ensures members receive the best and most current training in head and neck oncology. I am a member of the American Head and Neck Society with a role on the Microvascular Reconstructive Committee. In addition, I was recently named a Fellow of the American College of Surgeons.

My surgical and clinical expertise is in head and neck oncology, microvascular reconstruction, skin defect reconstruction, skull base surgery, robotic surgery, paragangliomas and carotid body tumors, and thyroid and parathyroid surgery. I have authored seven chapters on head and neck oncology and reconstruction and has more than 75 peer-reviewed publications.

My current research is focused on oncolytic viral therapy, HPV and head and neck cancer, and novel therapeutics for head and neck cancer. I’m working on multiple clinical trials with oncolytic viruses for head and neck cancer and metastatic disease.

I believe strongly in the mission of the OSUCCC – James to create a cancer-free world using cutting-edge research and individualized treatment for our patients. I’m humbled and inspired to be part of such a noble cause.

Education and Background


  • University of Texas Medical School at Houston

    Houston, TX


  • University of Michigan Hospitals

    Ann Arbor, MI


  • Head & Neck Surgery

    Vanderbilt University Medical Center

    Nashville, TN

Board Certifications

  • American Board of Otolaryngology

Academic Department

I see patients at

The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue, Columbus, Ohio 43210


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 12/20/2018, Dr. Old has reported no relationships with companies or entities.

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