Nicole O Williams, MD
Academic Title: Associate Professor in the College of Medicine
Research Program: Translational Therapeutics
About Me
More info forI am a medical oncologist who specializes in managing the treatment of patients with breast cancer. I serve as director of the BreastCARE Program in the Cancer and Aging Resiliency Clinic at the OSUCCC – James. I joined the Division of Medical Oncology at The Ohio State University in 2016 after completing my fellowship training in hematology and oncology and in breast oncology at University Hospitals/Case Western Reserve Medical Center in Cleveland. I also completed a geriatric medicine fellowship at Summa Health System in Akron, Ohio. My breast oncology fellowship training gave me extensive interdisciplinary experience in breast cancer assessment and treatment, including cancer genetics, imaging, prevention, surgical observation and radiation techniques. I have combined my clinical practice in breast medical oncology with my experience in breast genomics laboratory and clinical investigation. As a member of the Translational Therapeutics Program at the OSUCCC – James, my research is focused on treating breast cancer and brain metastases from breast cancer. I am also involved in clinical trials investigating new treatments for breast cancer in the neoadjuvant, adjuvant and metastatic settings. One study looks at how well fulvestrant and palbociclib work in treating older patients with breast cancer that responds to hormone treatment but cannot be removed by surgery. Since estrogen can cause the growth of estrogen-receptor-positive breast cancer cells, hormone therapy using fulvestrant may fight estrogen-receptor-positive breast cancer by blocking the use of estrogen by tumor cells, while palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. As a result, giving fulvestrant together with palbociclib may be an effective treatment for hormone-responsive breast cancer. I have co-authored numerous publications in such peer-reviewed journals as International Journal of Behavioral Medicine, Breast Cancer Research and Treatment, and International Journal of Cancer. Additionally, I am a member of several professional organizations, including the American Medical Association, the American College of Physicians, the American Society of Clinical Oncology, the American Society of Hematology and the American Association for Cancer Research.
Clinical Expertise
More info for- Breast Imaging
- Breast Cancer
Where I See Patients
More info forStefanie Spielman Comprehensive Breast Center
1145 Olentangy River Road Columbus, Ohio 43212 800-293-5066 Location InformationEducation & Training
More info forMedical School
- Northeast Ohio Medical University
Po Box 95, Rootstown, OH
Fellowship - Geriatric Medicine
- Summa Health System GME
Graduate Medical Education, Akron, OH
Internship - Internal Medicine
- Summa Health System GME
Graduate Medical Education, Akron, OH
Residency - Internal Medicine
- Summa Health System GME
Graduate Medical Education, Akron, OH
Fellowship - Breast Oncology
- University Hospitals Cleveland Medical Center
11100 Euclid Ave, Cleveland, OH
Fellowship - Hematology & Oncology
- University Hospitals Cleveland Medical Center
11100 Euclid Ave, Cleveland, OH
- Northeast Ohio Medical University
Academic Office & Contact Information
More info forAcademic Office:
Lincoln Tower 1335
1800 Cannon Dr
Columbus, Ohio 43210Email:
williams.6027@osu.eduReviews
More info forPatient Satisfaction Review
The overall patient satisfaction rating is an average of all patient responses to the five questions gathered from the Outpatient Oncology survey, developed by Press Ganey Associates for use in oncology clinics across the country. On behalf of The James, Press Ganey administers the survey to patients who see our providers in an outpatient clinic office. For additional information about the patient satisfaction survey, please visit our
Patient Satisfaction Survey page The comments are submitted by patients and reflect their view and opinions. The comments are not endorsed by and do not necessarily reflect the views of The James.
Publications
More info forSeptember 14, 2024Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial.
Shatsky RA, Trivedi MS, Yau C, Nanda R, Rugo HS, Davidian M, Tsiatis B, Wallace AM, Chien AJ, Stringer-Reasor E, Boughey JC, Omene C, Rozenblit M, Kalinsky K, Elias AD, Vaklavas C, Beckwith H, Williams N, Arora M, Nangia C, Roussos Torres ET, Thomas B, Albain KS, Clark AS, Falkson C, Hershman DL, Isaacs C, Thomas A, Tseng J, Sanford A, Yeung K, Boles S, Chen YY, Huppert L, Jahan N, Parker C, Giridhar K, Howard FM, Blackwood MM, Sanft T, Li W, Onishi N, Asare AL, Beineke P, Norwood P, Brown-Swigart L, Hirst GL, Matthews JB, Moore B, Symmans WF, Price E, Heditsian D, LeStage B, Perlmutter J, Pohlmann P, DeMichele A, Yee D, van 't Veer LJ, Hylton NM, Esserman LJ
Nat Med
July 19, 2024Subcutaneous vs Intravenous Trastuzumab/Pertuzumab: A Time and Motion Substudy of a Phase II Trial of Adjuvant Trastuzumab/Pertuzumab for Stage I HER2+ Breast Cancer (ADEPT trial).
Waks AG, Chen EL, Graham N, Frey AM, Almeida K, Attaya V, Ryding C, Abbass I, Fung A, Sussell J, Cortazar P, Harvey C, Leth D, Faggen M, Sinclair N, Walsh J, Tung N, Sinclair S, Lo S, Yardley D, Valero V, Meisel J, Ballinger TJ, Adams S, Carey LA, Rauch JK, Abramson VG, Williams NO, Chen WY, Leone JP, Schumer ST, Tayob N, Tolaney SM
JCO Oncol Pract
June 19, 2024The survival benefit of adjuvant trastuzumab with or without chemotherapy in the management of small (T1mic, T1a, T1b, T1c), node negative HER2+ breast cancer.
Johnson KCC, Ni A, Quiroga D, Pariser AC, Sudheendra PK, Williams NO, Sardesai SD, Cherian M, Stover DG, Gatti-Mays M, Ramaswamy B, Lustberg M, Jhawar S, Skoracki R, Wesolowski R
NPJ Breast Cancer
June 1, 2024Real-world treatment patterns of adjuvant endocrine therapy and ovarian suppression in premenopausal HR+/HER2+ breast cancer.
Sukumar JS, Sardesai S, Ni A, Williams N, Johnson K, Quiroga D, Ramaswamy B, Wesolowski R, Cherian M, Stover DG, Gatti-Mays M, Pariser A, Sudheendra P, George MA, Lustberg M
Cancer Med
May 30, 2024Chemotherapy-induced gut microbiome disruption, inflammation, and cognitive decline in female patients with breast cancer.
Otto-Dobos LD, Grant CV, Lahoud AA, Wilcox OR, Strehle LD, Loman BR, Adarkwah Yiadom S, Seng MM, Halloy N, Russart KLG, Carpenter KM, Dawson E, Sardesai SD, Williams NO, Gatti-Mays ME, Stover DG, Sudheendra PK, Wesolowski R, Kiecolt-Glaser JK, Bailey MT, Andridge RR, Pyter LM
Brain Behav Immun
December 27, 2023Stereotactic Radiosurgery for Women Older than 65 with Breast Cancer Brain Metastases.
Upadhyay R, Klamer BG, Perlow HK, White JR, Bazan JG, Jhawar SR, Blakaj DM, Grecula JC, Arnett A, Mestres-Villanueva MA, Healy EH, Thomas EM, Chakravarti A, Raval RR, Lustberg M, Williams NO, Palmer JD, Beyer SJ
Cancers (Basel)
November 22, 2023Retrospective cohort study of CDK4/6-inhibitor-induced alopecia in breast cancer patients.
Minta A, Rose L, Park C, Ramaswamy B, Stover D, Gatti-Mays M, Cherian M, Williams N, Sudheendra P, Wesolowski R, Sardesai S, Lustberg M, Loprinzi CL, Ruddy KJ, Cathcart-Rake E, Trovato S, Dulmage B
Support Care Cancer
October 14, 2023Survival outcomes seen with neoadjuvant chemotherapy in the management of locally advanced inflammatory breast cancer (IBC) versus matched controls.
Johnson KC, Grimm M, Sukumar J, Schnell PM, Park KU, Stover DG, Jhawar SR, Gatti-Mays M, Wesolowski R, Williams N, Sardesai S, Pariser A, Sudheendra P, Tozbikian G, Ramaswamy B, Doto D, Cherian MA
Breast
September 4, 2023Depression, Inflammation, and Intestinal Permeability: Associations with Subjective and Objective Cognitive Functioning throughout Breast Cancer Survivorship.
Madison AA, Andridge R, Kantaras AH, Renna ME, Bennett JM, Alfano CM, Povoski SP, Agnese DM, Lustberg M, Wesolowski R, Carson WE, Williams NO, Reinbolt RE, Sardesai SD, Noonan AM, Stover DG, Cherian MA, Malarkey WB, Kiecolt-Glaser JK
Cancers (Basel)
July 20, 2023Prediction of Malnutrition and the Relationships Among Pain, Function, Depression, and Cancer Stage in Older Women With Breast Cancer.
Overcash J, Goetz R, Williams N
Clin J Oncol Nurs
June 24, 2023The Immunomodulatory Effects of Dexamethasone on Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer.
Johnson KCC, Goldstein D, Tharakan J, Quiroga D, Kassem M, Grimm M, Miah A, Vargo C, Berger M, Sudheendra P, Pariser A, Gatti-Mays ME, Williams N, Stover D, Sardesai S, Wesolowski R, Ramaswamy B, Tozbikian G, Schnell PM, Cherian MA
Oncol Ther
March 22, 2023Conflicts hurt: social stress predicts elevated pain and sadness after mild inflammatory increases.
Madison AA, Renna M, Andridge R, Peng J, Shrout MR, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, Williams NO, Noonan AM, Reinbolt RE, Stover DG, Cherian MA, Malarkey WB, Kiecolt-Glaser JK
Pain
January 1, 2023A troubled heart: Mood disorder history longitudinally predicts faster cardiopulmonary aging in breast cancer survivorship.
Madison AA, Filatov M, Andridge R, Haas G, Povoski SP, Agnese DM, Lustberg M, Reinbolt RE, Wesolowski R, Williams NO, Malarkey WB, Kiecolt-Glaser JK
PLoS One
January 1, 2023Phase Ib study of HSP90 inhibitor, onalespib (AT13387), in combination with paclitaxel in patients with advanced triple-negative breast cancer.
Williams NO, Quiroga D, Johnson C, Brufsky A, Chambers M, Bhattacharya S, Patterson M, Sardesai SD, Stover D, Lustberg M, Noonan AM, Cherian M, Bystry DM, Hill KL, Chen M, Phelps MA, Grever M, Stephens JA, Ramaswamy B, Carson WE, Wesolowski R
Ther Adv Med Oncol
October 5, 2022Typhoid Vaccine Does Not Impact Feelings of Social Connection or Social Behavior in a Randomized Crossover Trial Among Middle-Aged Female Breast Cancer Survivors.
Madison AA, Way B, Ratner K, Renna M, Andridge R, Peng J, Rosie Shrout M, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, VanDeusen JB, Williams NO, Sardesai SD, Noonan AM, Reinbolt RE, Stover DG, Cherian MA, Malarkey WB, Kiecolt-Glaser JK
Brain Behav Immun
September 7, 2022Treatment of Brain Metastases: The Synergy of Radiotherapy and Immune Checkpoint Inhibitors.
Matsui JK, Perlow HK, Raj RK, Nalin AP, Lehrer EJ, Kotecha R, Trifiletti DM, McClelland S, Kendra K, Williams N, Owen DH, Presley CJ, Thomas EM, Beyer SJ, Blakaj DM, Ahluwalia MS, Raval RR, Palmer JD
Biomedicines
July 25, 2022Influence of Patient Functional Status and Depression on Strain in Caregivers.
Overcash J, Johnston M, Sinnott LT, Williams N
Clin J Oncol Nurs
July 13, 2022Distress Disorder Histories Relate to Greater Physical Symptoms Among Breast Cancer Patients and Survivors: Findings Across the Cancer Trajectory.
Renna ME, Shrout MR, Madison AA, Lustberg M, Povoski SP, Agnese DM, Reinbolt RE, Wesolowski R, Williams NO, Ramaswamy B, Sardesai SD, Noonan AM, VanDeusen JB, Stover DG, Cherian M, Malarkey WB, Di Gregorio M, Kiecolt-Glaser JK
Int J Behav Med
July 10, 2022Living with Advanced Breast Cancer: A Descriptive Analysis of Survivorship Strategies.
Grimm M, Radcliff L, Giles M, Nash R, Holley E, Panda S, Brophy L, Williams N, Cherian M, Stover D, Gatti-Mays ME, Wesolowski R, Sardesai S, Sudheendra P, Reinbolt R, Ramaswamy B, Pariser A
J Clin Med
April 1, 2022Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference.
Kiecolt-Glaser JK, Renna M, Peng J, Sheridan J, Lustberg M, Ramaswamy B, Wesolowski R, VanDeusen JB, Williams NO, Sardesai SD, Noonan AM, Reinbolt RE, Stover DG, Cherian MA, Malarkey WB, Andridge R
Brain Behav Immun
March 24, 2022Impact of Dose Intensity on Pathologic Complete Response Rate in HER2-Positive Breast Cancer Patients Receiving Neoadjuvant Docetaxel, Carboplatin, Trastuzumab and Pertuzumab (TCHP).
Le D, Vargo C, Collins S, Williams N, Palettas M, Berger M
Target Oncol
February 15, 2022Updates in the Treatment of Chemotherapy-Induced Peripheral Neuropathy.
Mezzanotte JN, Grimm M, Shinde NV, Nolan T, Worthen-Chaudhari L, Williams NO, Lustberg MB
Curr Treat Options Oncol
February 14, 2022Geriatric risk factors for serious COVID-19 outcomes among older adults with cancer: a cohort study from the COVID-19 and Cancer Consortium.
Elkrief A, Hennessy C, Kuderer NM, Rubinstein SM, Wulff-Burchfield E, Rosovsky RP, Vega-Luna K, Thompson MA, Panagiotou OA, Desai A, Rivera DR, Khaki AR, Tachiki L, Lynch RC, Stratton C, Elias R, Batist G, Kasi A, Shah DP, Bakouny Z, Cabal A, Clement J, Crowell J, Dixon B, Friese CR, Fry SL, Grover P, Gulati S, Gupta S, Hwang C, Khan H, Kim SJ, Klein EJ, Labaki C, McKay RR, Nizam A, Pennell NA, Puc M, Schmidt AL, Shahrokni A, Shaya JA, Su CT, Wall S, Williams N, Wise-Draper TM, Mishra S, Grivas P, French B, Warner JL, Wildes TM, COVID-19 and Cancer Consortium
Lancet Healthy Longev
January 31, 2022Long-Term Follow-Up of Fractional CO2 Laser Therapy for Genitourinary Syndrome of Menopause in Breast Cancer Survivors.
Quick AM, Hundley A, Evans C, Stephens JA, Ramaswamy B, Reinbolt RE, Noonan AM, Van Deusen JB, Wesolowski R, Stover DG, Williams NO, Sardesai SD, Faubion SS, Loprinzi CL, Lustberg MB
J Clin Med
October 1, 2021Assessment of Leptomeningeal Carcinomatosis Diagnosis, Management and Outcomes in Patients with Solid Tumors Over a Decade of Experience.
Rinehardt H, Kassem M, Morgan E, Palettas M, Stephens JA, Suresh A, Ganju A, Lustberg M, Wesolowski R, Sardesai S, Stover D, Vandeusen J, Cherian M, Prieto Eibl MDPG, Miah A, Alnahhas I, Giglio P, Puduvalli VK, Ramaswamy B, Williams N, Noonan AM
Adv Psychosom Med
September 8, 2021Patient preferences and adherence to adjuvant GnRH analogs among premenopausal women with hormone receptor positive breast cancer.
Sukumar JS, Quiroga D, Kassem M, Grimm M, Shinde NV, Appiah L, Palettas M, Stephens J, Gatti-Mays ME, Pariser A, Cherian M, Stover DG, Williams N, Van Deusen J, Wesolowski R, Lustberg M, Ramaswamy B, Sardesai S
Breast Cancer Res Treat
May 20, 2021Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer.
Weber ZT, Collier KA, Tallman D, Forman J, Shukla S, Asad S, Rhoades J, Freeman S, Parsons HA, Williams NO, Barroso-Sousa R, Stover EH, Mahdi H, Cibulskis C, Lennon NJ, Ha G, Adalsteinsson VA, Tolaney SM, Stover DG
Genome Med
May 18, 2021Genomic features of rapid versus late relapse in triple negative breast cancer.
Zhang Y, Asad S, Weber Z, Tallman D, Nock W, Wyse M, Bey JF, Dean KL, Adams EJ, Stockard S, Singh J, Winer EP, Lin NU, Jiang YZ, Ma D, Wang P, Shi L, Huang W, Shao ZM, Cherian M, Lustberg MB, Ramaswamy B, Sardesai S, VanDeusen J, Williams N, Wesolowski R, Obeng-Gyasi S, Sizemore GM, Sizemore ST, Verschraegen C, Stover DG
BMC Cancer
March 16, 2021Hospital Admissions Associated With Cancer Pain in Older Adults With and Without Dementia.
Strassels SA, Moss KO, Mallow PJ, Tamer RM, Monroe TB, Williams NO, Levine AS, Muench U
Pain Manag Nurs
February 27, 2021Comprehensive review of molecular mechanisms and clinical features of invasive lobular cancer.
Pramod N, Nigam A, Basree M, Mawalkar R, Mehra S, Shinde N, Tozbikian G, Williams N, Majumder S, Ramaswamy B
Oncologist
February 1, 2021Patient-reported sexual function of breast cancer survivors with genitourinary syndrome of menopause after fractional CO2 laser therapy.
Quick AM, Zvinovski F, Hudson C, Hundley A, Evans C, Stephens JA, Arthur E, Ramaswamy B, Reinbolt RE, Noonan AM, VanDeusen JB, Wesolowski R, Stover DG, Williams NO, Sardesai SD, Faubion SS, Loprinzi CL, Lustberg MB
Menopause
January 1, 2021Tumor lysis Syndrome in a Patient with Metastatic Breast Cancer Treated with Alpelisib.
Handy C, Wesolowski R, Gillespie M, Lause M, Sardesai S, Williams N, Grimm M, Kassem M, Ramaswamy B
Breast Cancer (Auckl)
January 1, 2021Integration of a Geriatric Assessment With Intervention in the Care of Older Adults With Hematologic Malignancies.
Wall SA, Huang Y, Keiter A, Funderburg A, Kloock C, Yuhasz N, Gure TR, Folefac E, Stevens E, Presley CJ, Williams NO, Krok-Schoen JL, Naughton MJ, Rosko AE
Front Oncol
January 1, 2021A Cardiac Rehabilitation Program for Breast Cancer Survivors: A Feasibility Study.
Zvinovski F, Stephens JA, Ramaswamy B, Reinbolt RE, Noonan AM, VanDeusen JB, Wesolowski R, Stover DG, Williams NO, Sardesai SD, Mehta L, Foraker R, Gulati M, Lustberg M, Quick AM
J Oncol
November 16, 2020Triple-negative breast cancer: promising prognostic biomarkers currently in development.
Sukumar J, Gast K, Quiroga D, Lustberg M, Williams N
Expert Rev Anticancer Ther
November 5, 2020Clinical impact of interruption in adjuvant Trastuzumab therapy in patients with operable HER-2 positive breast cancer.
Sardesai S, Sukumar J, Kassem M, Palettas M, Stephens J, Morgan E, Addison D, Baliga R, Stover DG, VanDeusen J, Williams N, Cherian M, Lustberg M, Wesolowski R, Ramaswamy B
Cardiooncology
November 1, 2020Worry and rumination in breast cancer patients: perseveration worsens self-rated health.
Renna ME, Rosie Shrout M, Madison AA, Lustberg M, Povoski SP, Agnese DM, Reinbolt RE, Wesolowski R, Williams NO, Ramaswamy B, Sardesai SD, Noonan AM, VanDeusen JB, Malarkey WB, Kiecolt-Glaser JK
J Behav Med
July 6, 2020Implementing a multidisciplinary approach for older adults with Cancer: geriatric oncology in practice.
Presley CJ, Krok-Schoen JL, Wall SA, Noonan AM, Jones DC, Folefac E, Williams N, Overcash J, Rosko AE
BMC Geriatr
July 1, 2020Features, Outcomes, and Management Strategies of Male Breast Cancer: A Single Institution Comparison to Well-Matched Female Controls.
Liu J, Suresh A, Palettas M, Stephens J, Ganju A, Morgan E, Kassem M, Hou Y, Parwani A, Noonan A, Reinbolt R, VanDeusen J, Sardesai S, Williams N, Cherian M, Tozbikian G, Stover DG, Lustberg M, Li Z, Ramaswamy B, Wesolowski R
Abstr Euro J of Hum Gen
May 19, 2020Exploratory analysis of immune checkpoint receptor expression by circulating T cells and tumor specimens in patients receiving neo-adjuvant chemotherapy for operable breast cancer.
Wesolowski R, Stiff A, Quiroga D, McQuinn C, Li Z, Nitta H, Savardekar H, Benner B, Ramaswamy B, Lustberg M, Layman RM, Macrae E, Kassem M, Williams N, Sardesai S, VanDeusen J, Stover D, Cherian M, Mace TA, Yu L, Duggan M, Carson WE
BMC Cancer
May 6, 2020Metastatic breast cancer patient perceptions of somatic tumor genomic testing.
Adams EJ, Asad S, Reinbolt R, Collier KA, Abdel-Rasoul M, Gillespie S, Chen JL, Cherian MA, Noonan AM, Sardesai S, VanDeusen J, Wesolowski R, Williams N, Shapiro CL, Macrae ER, Pilarski R, Toland AE, Senter L, Ramaswamy B, Lee CN, Lustberg MB, Stover DG
BMC Cancer
Consulting and Related Relationships
More info forAt The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 09/30/2024, Dr. Williams has reported no relationships with companies or entities.
Patient Comments
Nicole answered all of my concerns with empathy and expertise.
Nicole Williams makes me feel at ease and explains results of my scans etc..
Best doctors, PA's and staff! Excellent!
Had blood mammo and breast scan and infusion. Super helpful staff
I was a new patient at the James facility for breast cancer. I had just moved into this area and I was so nervous. I have had cancer for 10 years and I always fear that I will eventually not have any choices left, but Dr. Williams and her staff assure me that there are more choices.
I feel very confident that I am in good hands
Always good
Dr Williams and her team at the CARE Clinic are outstanding.
Answered all my questions
Everyone I saw was very nice and informative.
All good.
My oncologist and her PA are very knowledgeable and keep me well informed on everything!
They are very good in entertaining patients. Excellent job. Keep on doing the good work.
No recommendations to do this or to avoid this or these things were given to keep cancer away after being in remission 5 years. I just talked most of the appt.
Even on a tight busy schedule, every department/provider took the time needed to do the job the right way
Dr. Williams & staff are great!
Dr. Williams and Nancy Stasik gave me HOPE
Wonderful doctor Dr. Nicole Williams.