Sam Penza, MD

The James Cancer Center
Sam Penza

A physician, or doctor, is extensively trained to diagnose and treat complex medical problems. Often, physicians focus their practice on certain disease categories, treatment methods or patient types. Physicians can diagnose and treat illness, prescribe medication, offer medical consultation and advice, perform surgery and more.


  • Hematology

Clinical Expertise

  • Bone Marrow Cancers
  • Bone Marrow Transplantation
  • Peripheral Blood Stem Cell Transplantation
Insurance Information



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I’m a senior transplant physician with more than 20 years experience in blood and marrow/hematopoietic stem cell transplantation (BMT/HSCT). I have expertise in managing Graft vs. Host Disease (GVHD) and post-transplant infectious complications. My passion is identifying, developing and implementing system improvements and processes that will improve the quality of patient care and safety.

Additionally I serve as medical director of quality at The James and physician advisor for Ohio State. I’m involved in more than a dozen clinical trials of new therapies to treat BMT/HSCT transplant issues and complications.

I’m pleased to have been honored by multiple years of clinical recognition by America’s Best Doctors, Top Doctors in Central Ohio, America's Top Physicians and Best Doctors in Columbus. I’ve been recognized for having high patient satisfaction, and was named as professor of the year from the College of Medicine.

I believe in the OSUCCC – James’ three-pronged mission of excellence in patient care, teaching and research to improve the quality of life for all patients. As I see it, the patient is my focus — not just his or her disease.

Being in an academic environment is very rewarding and I serve as a professor of clinical internal medicine for The Ohio State University College of Medicine. I enjoy teaching medical students and residents how to deliver quality, compassionate care. I view myself as having a critical role in educating the next generation of doctors.

Education and Background


  • Ohio State University College of Medicine

    Columbus, OH


  • Hematology/Oncology

    Ohio State University Wexner Medical Center

    Columbus, OH

Board Certifications

  • American Board of Internal Medicine
  • American Board of Internal Medicine (Subspecialty: Hematology)
  • American Board of Internal Medicine (Subspecialty: Medicine Oncology)

Academic Department

I see patients at

The James Cancer Hospital and Solove Research Institute

460 West 10th Avenue, Columbus, Ohio 43210


Consulting and Related Relationships

At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 12/20/2018, Dr. Penza has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.

  • Merck & Co., Inc.
  • Astellas Pharma, Inc.
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