Deliang Guo, PhD
Leadership Title: Urban and Shelley Meyer Professorship in Cancer
Academic Title: Professor in the College of Medicine
Research Program: Translational Therapeutics
Columbus, Ohio 43210-2208
About Me
More info forI am a professor in the Department of Radiation Oncology at The Ohio State University and a member of the Translational Therapeutics Program at the OSUCCC – James, where my work is focused on determining the key molecular targets in cancer metabolism and translating those findings into the clinical setting.
I am the co-holder of a patent on a novel strategy for targeting EGFR-activated glioblastoma, the most lethal form of brain cancer. My recent research includes work that first identifies that lipid droplets are unique organelles enriched in glioblastoma patient tumor tissues and suggests a novel therapeutic strategy to treat this disease by interrupting lipid-droplet metabolism. I have also been part of research targeting SREBP-1-driven lipid metabolism to treat cancer.
I have co-authored a dozen articles in prestigious publications, such as Neuro-Oncology, Current Pharmaceutical Design, Clinical Cancer Research and Journal of Translational Medicine. He has also made presentations to various organizations, including the American Heart Association and American Association for Cancer Research.
Research Interests
More info for- Glioblastoma
- Neoplasms
- Glioma
- Brain Neoplasms
- Melanoma
Academic Office & Contact Information
More info forAcademic Office:
Tzagournis Medical Research Fa 0544
420 W 12th Ave
Columbus, Ohio 43210-2208Phone:
614-366-3774Email:
guo.416@osu.eduPublications
More info forSeptember 1, 2024Tumor cells utilize acetate for tumor growth and immune evasion.
Sun P, Liu J, Guo D
MedComm (2020)
August 28, 2024Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma.
Zhong Y, Geng F, Mazik L, Yin X, Becker AP, Mohammed S, Su H, Xing E, Kou Y, Chiang CY, Fan Y, Guo Y, Wang Q, Li PK, Mo X, Lefai E, He L, Cheng X, Zhang X, Chakravarti A, Guo D
Cell Rep Med
May 31, 2024The thioredoxin system determines CHK1 inhibitor sensitivity via redox-mediated regulation of ribonucleotide reductase activity.
Prasad CB, Oo A, Liu Y, Qiu Z, Zhong Y, Li N, Singh D, Xin X, Cho YJ, Li Z, Zhang X, Yan C, Zheng Q, Wang QE, Guo D, Kim B, Zhang J
Nat Commun
May 6, 2024STAT3 activation of SCAP-SREBP-1 signaling upregulates fatty acid synthesis to promote tumor growth.
Fan Y, Zhang R, Wang C, Pan M, Geng F, Zhong Y, Su H, Kou Y, Mo X, Lefai E, Han X, Chakravarti A, Guo D
J Biol Chem
November 5, 2023SREBF1/SREBP-1 concurrently regulates lipid synthesis and lipophagy to maintain lipid homeostasis and tumor growth.
Geng F, Guo D
Autophagy
September 30, 2023Unlocking Translational Potential: Conditionally Reprogrammed Cells in Advancing Breast Cancer Research.
Daneshdoust D, Luo M, Li Z, Mo X, Alothman S, Kallakury B, Schlegel R, Zhang J, Guo D, Furth PA, Liu X, Li J
Cells
July 25, 2023SREBP-1 upregulates lipophagy to maintain cholesterol homeostasis in brain tumor cells.
Geng F, Zhong Y, Su H, Lefai E, Magaki S, Cloughesy TF, Yong WH, Chakravarti A, Guo D
Cell Rep
May 9, 2022Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth.
Cheng C, Geng F, Li Z, Zhong Y, Wang H, Cheng X, Zhao Y, Mo X, Horbinski C, Duan W, Chakravarti A, Cheng X, Guo D
Nat Metab
January 19, 2022Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy.
Hong Z, Liu T, Wan L, Fa P, Kumar P, Cao Y, Prasad CB, Qiu Z, Liu J, Wang H, Li Z, Wang QE, Guo P, Guo D, Yilmaz AS, Lu L, Papandreou I, Jacob NK, Yan C, Zhang X, She QB, Ma Z, Zhang J
Cancer Res
October 23, 2020Lipid Droplets Maintain Energy Homeostasis and Glioblastoma Growth via Autophagic Release of Stored Fatty Acids.
Wu X, Geng F, Cheng X, Guo Q, Zhong Y, Cloughesy TF, Yong WH, Chakravarti A, Guo D
iScience
September 8, 2020DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy.
Cheng X, Geng F, Guo D
Mol Cell Oncol
June 9, 2020Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress.
Cheng X, Geng F, Pan M, Wu X, Zhong Y, Wang C, Tian Z, Cheng C, Zhang R, Puduvalli V, Horbinski C, Mo X, Han X, Chakravarti A, Guo D
Cell Metab