Francesca Cottini, MD
Academic Title: Assistant Professor in the College of Medicine
Research Program: Leukemia and Hematologic Malignancies
About Me
More info forI am a hematologist who specializes in the treatment of patients with plasma cell disorders, such as multiple myeloma and amyloidosis. I completed my residency and hematology/medical oncology fellowship here at The Ohio State University, where I became passionate about how the immune system affects myeloma growth, response to therapy and risk of infections. As a cancer-treating physician, my goal is to tailor therapies, reduce toxicities and improve the quality of life of my patients. At the OSUCCC – James, we work as a multidisciplinary team to identify and test innovative therapeutic approaches in the lab that can be rapidly applied to patients in the clinic. This derives from the perfect interactions between bench research, drug development efforts and clinical care. As a member of the Translational Therapeutics Program at the OSUCCC – James, my laboratory research focuses on the development of translational therapeutics for patients with multiple myeloma. My objective is to integrate concepts of myeloma biology, genomics and immunotherapy to improve patient outcomes by personalized therapeutic approaches. Currently, I am developing novel therapeutic approaches to benefit patients at high risk of poor outcomes, using both 2D and 3D models to study the interactions between myeloma cells and the tumor microenvironment. My work has been patented, presented at major conferences and published in numerous peer-reviewed journals, including Nature Medicine, Cancer Discovery, Blood Cancer Journal, Leukemia, Blood, Leukemia & Lymphoma, and Amyloid. I am a member of national and international scientific organizations, such as the American Society of Hematology, the European Hematology Association and the American Society of Clinical Oncology. I also serve as a reviewer for several scientific journals. My research has been supported by the Multiple Myeloma Research Foundation, the International Myeloma Society, the Pelotonia Foundation, the Pardee Foundation, and the National Cancer Institute. In addition to my clinical and research work, I am an assistant professor in the Division of Hematology at The Ohio State University, where I help to train the next generation of cancer physicians and researchers. I love working at the OSUCCC – James because it provides me various avenues to contribute to our mission of creating a cancer-free world. Everybody is dedicated to providing optimal care for our patients and progressing our research with laboratory science and clinical trials.
Clinical Expertise
More info for- Hematology
- Multiple Myeloma
- Amyloidosis
Research Interests
More info for- Amyloidosis
- Biomarkers
- Cell Biology
Education & Training
More info forFellowship - Medical Oncology
- Dana-Farber Cancer Institute
44 Binney St, Boston, MA
Medical School
- Libera Universita Vita Salute S. Raffaele Milano
Via Olgettina Milano, 58, Milano
Fellowship - Hematology & Oncology
- Ohio State University Wexner Medical Center
700 Ackerman Rd, Columbus, OH
Internship - Internal Medicine
- Ohio State University Wexner Medical Center
700 Ackerman Rd, Columbus, OH
Residency - Internal Medicine
- Ohio State University Wexner Medical Center
700 Ackerman Rd, Columbus, OH
Fellowship - Medical Oncology
- San Raffaele Hospital
Via Olgettina Milano, Milan
- Dana-Farber Cancer Institute
Academic Office & Contact Information
More info forAcademic Office:
Comprehensive Cancer Center 0370C
410 W 12th Ave
Columbus, Ohio 43210-1214Phone:
614-292-6818Email:
francesca.cottini@osumc.eduPublications
More info forJune 20, 2024CREB1 promotes expression of immune checkpoint HLA-E leading to immune escape in multiple myeloma.
Ismael A, Robinette AJ, Huric L, Schuetz J, Dona K, Benson D, Cocucci E, Cottini F
Leukemia
April 12, 2024CD56 expression predicts response to Daratumumab-based regimens.
Robinette AJ, Huric L, Dona K, Benson D, Cottini F
Blood Cancer J
November 10, 2023Concomitant 1q+ and t(4;14) influences disease characteristics, immune system, and prognosis in double-hit multiple myeloma.
Ozga M, Zhao Q, Huric L, Miller C, Rosko A, Khan A, Umyarova E, Benson D, Cottini F
Blood Cancer J
August 17, 2023Understanding DNA Damage Response and DNA Repair in Multiple Myeloma.
Petrilla C, Galloway J, Kudalkar R, Ismael A, Cottini F
Cancers (Basel)
July 27, 2023TTK/MPS1 inhibitor OSU-13 targets the mitotic checkpoint and is a potential therapeutic strategy for myeloma.
Longo LVG, Hughes T, McNeil-Laidley B, Cottini F, Hilinski G, Merritt E, Benson DM
Haematologica
July 13, 2023Modified carfilzomib dosing is associated with improved treatment responses and longer time on treatment in patients with multiple myeloma.
Khan AM, Dvorak K, Zhao Q, Bumma N, Cottini F, Devarakonda S, Umyarova E, Sharma N, Benson D, Rosko A
Haematologica
July 1, 2023Characterization of monoclonal gammopathy of undetermined significance progression to multiple myeloma through meta-analysis of GEO data.
Aljabban J, Syed S, Syed S, Rohr M, Mukhtar M, Aljabban H, Cottini F, Mohammed M, Hughes T, Gonzalez T, Panahiazr M, Hadley D, Benson D
Heliyon
May 18, 2023Survival outcomes following autologous stem cell transplant with melphalan 140mg/m2 versus 200mg/m2 preparative regimens in patients with multiple myeloma.
Sharma N, Benson E, Zhao Q, Nunnelee J, Cottini F, Elder P, Rosko A, Bumma N, Khan A, Umyarova E, Devarakonda S, Efebera YA, Benson DM
Leuk Lymphoma
February 1, 2023Transformed Plasmablastic Lymphoma Presenting With Marked Lymphocytosis and Spontaneous Tumor Lysis Syndrome.
Hadjiyannis Y, Miller C, Hollie NI, Balakrishna J, Cottini F
J Hematol (Brossard)
January 1, 2023Impact of interval progression before autologous stem cell transplant in patients with multiple myeloma.
Bao A, Zhao Q, Kudalkar R, Rodriguez J, Sharma N, Bumma N, Devarakonda SS, Khan AM, Umyarova E, Rosko AE, Benson D, Cottini F
Front Oncol
December 5, 2022Outcomes After Salvage Autologous Hematopoietic Cell Transplant for Patients With Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience.
Khan AM, Ozga M, Bhatt H, Faisal MS, Ansari S, Zhao Q, Bumma N, Cottini F, Devarakonda S, Rosko A, Sharma N, Umyarova E, Benson D
Clin Lymphoma Myeloma Leuk
October 27, 2022Comparison of Patient Outcomes With Two Different Formulations of Melphalan as Conditioning Chemotherapy for Autologous Hematopoietic Cell Transplantation in Multiple Myeloma.
Khan AM, Yucebay F, Zhao Q, Umyarova E, Cottini F, Bumma N, Rosko A, Benson D, Sharma N, Efebera Y, Devarakonda S
Clin Lymphoma Myeloma Leuk
July 27, 2022Racial differences as predictors of outcomes in young patients with multiple myeloma.
Bao A, Zhao Q, Merritt E, Bumma N, Devarakonda S, Khan AM, Umyarova E, Rosko AE, Benson DM, Cottini F
Blood Cancer J
May 3, 2022Improvement in Post-Autologous Stem Cell Transplant Survival of Multiple Myeloma Patients: A Long-Term Institutional Experience.
Nunnelee J, Cottini F, Zhao Q, Faisal MS, Elder P, Rosko A, Bumma N, Khan A, Devarakonda S, Benson DM, Efebera Y, Sharma N
Cancers (Basel)
April 5, 2022Redefining CD56 as a biomarker and therapeutic target in Multiple Myeloma.
Cottini F, Rodriguez J, Hughes T, Sharma N, Guo L, Lozanski G, Liu B, Cocucci E, Yang Y, Benson D
Mol Cancer Res
January 1, 2022Incidence, Treatment, and Survival of Patients With T-Cell Lymphoma, T-Cell Large Granular Leukemia, and Concomitant Plasma Cell Dyscrasias.
Braunstein Z, McLaughlin E, Ruiz M, Wei L, Bumma N, Benson D, Devarakonda S, Chaudhry M, Khan A, Cottini F, Hanel W, Baiocchi R, Chung C, Addison D, Couette N, Meara A, Jarjour W, Porcu P, Mishra A, Reneau JC, Rosko AE, Brammer JE
Front Oncol
July 7, 2021Functional expression of aryl hydrocarbon receptor as a potential novel therapeutic target in human multiple myeloma.
Hughes T, Cottini F, Catton E, Ciarlariello D, Chen L, Yang Y, Liu B, Mundy-Bosse BL, Benson DM
Leuk Lymphoma
Consulting and Related Relationships
More info forAt The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 09/30/2024, Dr. Cottini has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.
- sanofi
- Cardinal Health
- techspert.io
- Mosaic Research Management
- Multiple Myeloma Research Foundation