John Spencer Gunn, PhD
Academic Title: Professor
Research Program: Cancer Biology
Columbus, Ohio 43205
About Me
More info forI am a professor in the Department of Pediatrics at The Ohio State University and Nationwide Children’s Center for Microbial Pathogenesis, as well as a member of the Cancer Biology Program at the OSUCCC – James, where my research centers on microbial resistance to innate immunity. In particular, I am focused on the macrophage as well as the mucosal surface.
In one of my studies, I am using a mouse model to determine if S. Typhi gallbladder carriage leads to cancer. If so, this finding could contribute significantly to early detection or prevention of gallbladder cancer. It also could indicate a broader relationship between chronic infections and cancer.
I have authored or co-authored many articles in well-respected publications, including the Journal of Biological Chemistry, Frontiers in Microbiology, Antimicrobial Agents and Chemotherapy, and International Journal of Pharmaceutics.
Research Interests
More info for- Infection
- Tularemia
- Typhoid Fever
- Carrier State
Academic Office & Contact Information
More info forAcademic Office:
Children's Hospital - Educatio
700 Childrens Dr
Columbus, Ohio 43205Phone:
614-292-5495Publications
More info forMarch 8, 2024Current vaccine strategies and novel approaches to combatting Francisella infection.
Harrell JE, Roy CJ, Gunn JS, McLachlan JB
Vaccine
April 6, 2020Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia.
Tang J, Tu S, Lin G, Guo H, Yan C, Liu Q, Huang L, Tang N, Xiao Y, Pope RM, Rajaram MVS, Amer AO, Ahmer BM, Gunn JS, Wozniak DJ, Tao L, Coppola V, Zhang L, Langdon WY, Torrelles JB, Lipkowitz S, Zhang J
J Exp Med