Maria MILKOVA Mihaylova, PhD
Academic Title: Assistant Professor in the College of Medicine
Research Program: Molecular Carcinogenesis and Chemoprevention
About Me
More info forI am an assistant professor in the Department of Biomedical Sciences at The Ohio State University and a recipient of the Block Lectureship Junior Faculty Award. As a member of the Molecular Carcinogenesis and Chemoprevention Program at the OSUCCC – James, I am interested in understanding the effects of diet and aging on cellular metabolism.
It is now appreciated that organismal and cellular metabolism can become deregulated with age, which can potentially accelerate cancer initiation or progression. One area of focus in my lab is understanding how metabolic deregulation in the gastrointestinal tract and liver can augment tissue homeostasis and promote age-related pathologies, including cancer.
By employing a number of genetic and multidisciplinary analytical approaches in both mouse models and 3D organoid culture systems, I hope ultimately to translate metabolic liabilities into potential therapeutics.
I have authored and co-authored studies published in peer-reviewed journals, such as Cell Stem Cell, Cell, Aging Cell and Cell Reports.
Education & Training
More info forPost-doctoral - PhD
- University of California-San Diego / Salk Institute
San Diego, CA
USA
Post-doctoral - Post Doc
- Massachusetts Institute of Technology / Whitehead Institute
Cambridge, MA
USA
- University of California-San Diego / Salk Institute
Academic Office & Contact Information
More info forAcademic Office:
1645 Neil Ave
Columbus, Ohio 43210-1218Email:
Maria.Mihaylova@osumc.eduPublications
More info forMay 15, 2024Determination of fatty acid uptake and desaturase activity in mammalian cells by NMR-based stable isotope tracing.
Lin P, Sledziona J, Akkaya-Colak KB, Mihaylova MM, Lane AN
Anal Chim Acta
March 1, 2024Mass Spectrometry Imaging and Histology for the Analysis of Budding Intestinal Organoids.
Sekera ER, Akkaya-Colak KB, Lopez A, Mihaylova MM, Hummon AB
Anal Chem
January 1, 2024Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.
Kolonay DW, Sattler KM, Strawser C, Rafael-Fortney J, Mihaylova MM, Miller KE, Lepper C, Baskin KK
Front Cell Dev Biol
June 22, 2022Colorectal Cancer Risk Is Impacted by Sex and Type of Surgery After Bariatric Surgery.
Hussan H, Akinyeye S, Mihaylova M, McLaughlin E, Chiang C, Clinton SK, Lieberman D
Obes Surg
June 8, 2021High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity.
Mana MD, Hussey AM, Tzouanas CN, Imada S, Barrera Millan Y, Bahceci D, Saiz DR, Webb AT, Lewis CA, Carmeliet P, Mihaylova MM, Shalek AK, Yilmaz ÖH
Adv Biochem Eng Biotechnol
June 1, 2021Metabolic Regulation of Stem Cells in Aging.
Keller A, Temple T, Sayanjali B, Mihaylova MM
Adv Psychosom Med
January 1, 2021Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft-Versus-Host Disease.
Snyder KJ, Choe HK, Gao Y, Sell NE, Braunreiter KM, Zitzer NC, Neidemire-Colley L, Kalyan S, Dorrance AM, Keller A, Mihaylova MM, Singh S, Sehgal L, Bollag G, Ma Y, Powell B, Devine SM, Ranganathan P
Front Oncol