Nicole R Grieselhuber, MD, PhD

Nicole R Grieselhuber, MD, PhD

Physician

Specialty:Hematology

Gender: female

Academic Title: Assistant Professor in the College of Medicine

Research Program: Leukemia and Hematologic Malignancies

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614-293-3196
  • About Me

    I am a medical oncologist who specializes in treating patients with blood cancers like acute myeloid leukemia (AML) and myelodysplastic syndrome. I received my doctor of medicine from the Washington University School of Medicine in St. Louis and completed my fellowship in hematology and oncology right here at The Ohio State University. As a member of the Leukemia and Hematologic Malignancies Program at the OSUCCC – James, my primary research focus is on myeloid malignancies, specifically working to better understand how leukemia develops and how leukemia cells respond to novel targeted therapies. Current research projects include pre-clinical investigations of BET inhibitors in combination with other targeted therapies in pre-clinical models of acute myeloid leukemia and basic investigations into the role of BET proteins in leukemogenesis. This works relies heavily upon the use of primary patient samples procured by the Leukemia Tissue Bank, both in in vitro assays and patient-derived xenografts. I’m very passionate about seeing discoveries from this research translated into improved treatment options for leukemia patients at The James and around the world. In addition to my clinical work and research, I serve as an assistant professor in the Division of Hematology, Department of Internal Medicine at Ohio State. I am also a member of several professional organizations, including the American Society of Clinical Oncology, the American Society of Hematology and the American College of Physicians. I am honored to be a part of the OSUCCC – James. The close collaboration between everyone in the hospital is truly unique, and it’s rewarding both personally and professionally to be able to work alongside a diverse team of smart, hardworking clinicians and researchers who are focused on improving the lives of leukemia patients and achieving our ultimate goal of a cancer-free world.

  • Clinical Expertise

    • Hematology
  • Where I See Patients

    The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

    The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

    Location Information
  • Education & Training

    Fellowship - Hematology & Oncology

    • Ohio State University Wexner Medical Center
      700 Ackerman Rd, Columbus, OH

    Internship - Internal Medicine

    • Ohio State University Wexner Medical Center
      700 Ackerman Rd, Columbus, OH

    Residency - Internal Medicine

    • Ohio State University Wexner Medical Center
      700 Ackerman Rd, Columbus, OH

    Medical School

    • Washington University School of Medicine
      660 S Euclid Ave, Saint Louis, MO
  • Academic Office & Contact Information

    Academic Office:

    Comprehensive Cancer Center 0456
    410 W 12th Ave
    Columbus, Ohio 43210-1214

  • Publications

    June 12, 2024

    Impact of chronic graft-versus-host disease on non-relapse mortality and survival.

    Jiang J, Sigmund AM, Zhao Q, Elder P, Vasu S, Jaglowski S, Mims A, Choe H, Larkin K, Wall S, Grieselhuber N, William B, Penza S, Benson DM, Efebera YA, Sharma N

    Leuk Lymphoma

    March 4, 2024

    The multi-CDK inhibitor dinaciclib reverses bromo- and extra-terminal domain (BET) inhibitor resistance in acute myeloid leukemia via inhibition of Wnt/β-catenin signaling.

    Marr AR, Halpin M, Corbin DL, Asemelash Y, Sher S, Gordon BK, Whipp EC, Mitchell S, Harrington BK, Orwick S, Benrashid S, Goettl VM, Yildiz V, Mitchell AD, Cahn O, Mims AS, Larkin KTM, Long M, Blachly J, Woyach JA, Lapalombella R, Grieselhuber NR

    Exp Hematol Oncol

    November 14, 2022

    Longitudinal Survival Outcomes in Allogeneic Stem Cell Transplantation: An Institutional Experience.

    Jiang J, Sigmund AM, Zhao Q, Elder P, Benson DM, Vasu S, Jaglowski S, Mims A, Choe H, Larkin K, Brammer JE, Wall S, Grieselhuber N, Saad A, Penza S, Efebera YA, Sharma N

    Cancers (Basel)

    January 1, 2022

    Impact of Race and Geographic Area of Residence on Outcomes After Allogeneic Stem Cell Transplant.

    Sigmund AM, Zhao Q, Jiang J, Elder P, Benson DM, Rosko A, Bumma N, Khan A, Devarakonda S, Vasu S, Jaglowski S, Mims A, Choe H, Larkin K, Brammer J, Wall S, Grieselhuber N, Saad A, Penza S, Efebera YA, Sharma N

    Front Oncol

    November 17, 2021

    PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in Acute Myeloid Leukemia.

    Goswami S, Mani R, Nunes J, Chiang CL, Zapolnik K, Hu EY, Frissora FW, Mo XM, Walker LA, Yan PS, Bundschuh R, Beaver L, Devine RD, Tsai YT, Ventura AM, Xie Z, Chen M, Lapalombella R, Walker AR, Mims AS, Larkin K, Grieselhuber NR, Bennett C, Phelps MA, Hertlein E, Behbehani GK, Vasu S, Byrd JC, Muthusamy N

    Blood

    October 28, 2021

    Diagnostic utility of bronchoscopy in newly diagnosed acute leukemia patients.

    Koenig KL, Curley TP, Mani S, Keiter A, Zhao Q, Behbehani GK, Bhatnagar B, Blachly JS, Haque TZ, Larkin KTM, Long M, Mims AS, Vasu S, Wall SA, Byrd JC, Lustberg M, Walker AR, Grieselhuber NR

    Hematol Oncol

    June 27, 2021

    Outcomes of Bone Marrow Compared to Peripheral Blood for Haploidentical Transplantation.

    Sharma N, Faisal MS, Zhao Q, Jiang J, Elder P, Benson DM, Rosko A, Chaudhry M, Bumma N, Khan A, Devarakonda S, Vasu S, Jaglowski S, Mims AS, Choe H, Larkin K, Brammer JE, Wall S, Grieselhuber N, Saad A, Penza S, Sigmund AM, Efebera YA

    J Clin Med

    May 21, 2021

    Genomic analysis of cellular hierarchy in acute myeloid leukemia using ultrasensitive LC-FACSeq.

    Saygin C, Hu E, Zhang P, Sher S, Lozanski A, Doong TJ, Nicolet D, Orwick S, Labanowska J, Skinner JN, Cempre C, Kauffman T, Goettl VM, Heerema NA, Abruzzo L, Miller C, Lapalombella R, Behbehani G, Mims AS, Larkin K, Grieselhuber N, Walker A, Bhatnagar B, Bloomfield CD, Byrd JC, Lozanski G, Blachly JS

    Leukemia

    March 24, 2021

    Type of prior genotoxic insult determines the genomic characteristics of therapy-related myeloid neoplasms.

    Ozga M, Blachly J, Eisfeld AK, Grieselhuber N, Larkin K, Walker A, Bhatnagar B, Behbehani G, Long M, Haque T, Vasu S, Zhao W, Jones D, Byrd JC, Mims AS, Saygin C

    Am J Hematol

    March 18, 2021

    Novel Targeted Therapeutics in Acute Myeloid Leukemia: an Embarrassment of Riches.

    Grieselhuber NR, Mims AS

    Curr Hematol Malig Rep

    February 4, 2021

    Targeting DNA damage repair functions of two histone deacetylases, HDAC8 and SIRT6, sensitizes acute myeloid leukemia to NAMPT inhibition.

    Zhang P, Brinton LT, Williams K, Sher S, Orwick S, Lai TH, Mims AS, Coss CC, Kulp SK, Youssef Y, Chan WK, Mitchell S, Mustonen A, Cannon M, Phillips H, Lehman AM, Kauffman T, Beaver L, Canfield D, Grieselhuber NR, Alinari L, Sampath D, Yan P, Byrd JC, Blachly JS, Lapalombella R

    Clin Cancer Res

    February 4, 2021

    Effect of Early Post-Transplantation Tacrolimus Concentration on the Risk of Acute Graft-Versus-Host Disease in Allogenic Stem Cell Transplantation.

    Sharma N, Zhao Q, Ni B, Elder P, Puto M, Benson DM, Rosko A, Chaudhry M, Devarakonda S, Bumma N, Khan A, Vasu S, Jaglowski S, William BM, Mims A, Choe H, Larkin K, Brammer J, Wall S, Grieselhuber N, Saad A, Penza S, Efebera Y

    Cancers (Basel)

    September 4, 2020

    Incidence of venous thrombosis after peg-asparaginase in adolescent and young adults with acute lymphoblastic leukemia.

    Underwood B, Zhao Q, Walker AR, Mims AS, Vasu S, Long M, Z Haque T, Blaser BW, Grieselhuber NR, Wall SA, Behbehani GK, Blachly JS, Larkin K, Byrd JC, Garzon R, Wang TF, Bhatnagar B

    Int J Hematol Oncol

  • Consulting and Related Relationships

    At The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 09/30/2024, Dr. Grieselhuber has reported no relationships with companies or entities.