About Me
More info forI am a professor and vice chair of experimental pathology in the Department of Pathology at The Ohio State University. I am also a member of the Cancer Biology Program at the OSUCCC – James, where the focus of my research lab is to elucidate mechanisms that regulate tumor growth and metastasis. My team is also developing immune-based therapies for solid tumors.
In my research, I have identified signaling pathways that regulate tumor growth, chemo-invasion and metastasis of tumor cells, especially in breast cancer. In particular, my team has discovered several biomarkers and signaling molecules that regulate growth and metastasis of triple-negative breast cancer (TNBC), including fatty acid binding protein 5 and transient receptor potential vanilloid type-2 (TRPV2).
One of my recent projects indicated for the first time that TRPV2 could be a good prognostic marker for TNBC and estrogen receptor alpha-negative (ERa-) breast cancer patients, especially among patients who receive chemotherapy.
Research Interests
More info for- Signal Transduction
- Neoplasms
- Tumor Microenvironment
- Inflammation
- Lung Neoplasms
- Breast Neoplasms
- Neoplasm Metastasis
Academic Office & Contact Information
More info forAcademic Office:
Biomedical Research Tower 0810
460 W 12th Ave
Columbus, Ohio 43210-2210Phone:
614-292-5539Email:
ganju.1@osu.eduPublications
More info forJuly 15, 2022Slit2/Robo1 signaling inhibits small cell lung cancer by targeting β-catenin signaling in tumor cells and macrophages.
Ahirwar DK, Peng B, Charan M, Misri S, Mishra S, Kaul K, Sassi S, Gadepalli VS, Siddiqui J, Miles WO, Ganju RK
Mol Oncol
February 24, 2022Cannabidiol Inhibits Tumorigenesis in Cisplatin-Resistant Non-Small Cell Lung Cancer via TRPV2.
Misri S, Kaul K, Mishra S, Charan M, Verma AK, Barr MP, Ahirwar DK, Ganju RK
Cancers (Basel)
February 8, 2022cPLA2 blockade attenuates S100A7-mediated breast tumorigenicity by inhibiting the immunosuppressive tumor microenvironment.
Mishra S, Charan M, Shukla RK, Agarwal P, Misri S, Verma AK, Ahirwar DK, Siddiqui J, Kaul K, Sahu N, Vyas K, Garg AA, Khan A, Miles WO, Song JW, Bhutani N, Ganju RK
J Exp Clin Cancer Res
January 1, 2022Augmentation of Extracellular ATP Synergizes With Chemotherapy in Triple Negative Breast Cancer.
Manouchehri JM, Datta J, Willingham N, Wesolowski R, Stover D, Ganju RK, Carson WE, Ramaswamy B, Cherian MA
Front Oncol
January 1, 2022Editorial: Inflammation and Myeloid Cells in Cancer Progression and Metastasis.
Mishra S, Ahirwar DK, Srivastava AK, Tripathi PP, Ganju RK
Front Cell Dev Biol
January 1, 2022Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer.
Datta J, Willingham N, Manouchehri JM, Schnell P, Sheth M, David JJ, Kassem M, Wilson TA, Radomska HS, Coss CC, Bennett CE, Ganju RK, Sardesai SD, Lustberg M, Ramaswamy B, Stover DG, Cherian MA
Front Oncol
November 28, 2021Cancer Treatment: Preclinical & Clinical.
Abrams DI, Velasco G, Twelves C, Ganju RK, Bar-Sela G
J Natl Cancer Inst Monogr
August 16, 2021Slit2 inhibits breast cancer metastasis by activating M1-like phagocytic and anti-fibrotic macrophages.
Ahirwar DK, Charan M, Mishra S, Verma AK, Shilo K, Ramaswamy B, Ganju RK
Cancer Res
May 9, 2021Lipopolysaccharide from the commensal microbiota of the breast enhances cancer growth: role of S100A7 and TLR4.
Wilkie T, Verma AK, Zhao H, Charan M, Ahirwar DK, Kant S, Pancholi V, Mishra S, Ganju RK
Mol Oncol
March 1, 2021Directional Migration of Breast Cancer Cells Hindered by Induced Electric Fields May Be Due to Accompanying Alteration of Metabolic Activity.
Jones TH, Kaul K, Garg AA, Song JW, Ganju RK, Subramaniam VV
Bioelectricity
January 1, 2021Racially Disparate Expression of mTOR/ERK-1/2 Allied Proteins in Cancer.
Mishra S, Charan M, Verma AK, Ramaswamy B, Ahirwar DK, Ganju RK
Front Cell Dev Biol
January 1, 2021Slit2-Mediated Metabolic Reprogramming in Bone Marrow-Derived Macrophages Enhances Antitumor Immunity.
Kaul K, Benej M, Mishra S, Ahirwar DK, Yadav M, Stanford KI, Jacob NK, Denko NC, Ganju RK
Front Immunol
September 17, 2020Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer.
Charan M, Das S, Mishra S, Chatterjee N, Varikuti S, Kaul K, Misri S, Ahirwar DK, Satoskar AR, Ganju RK
Adv Biochem Eng Biotechnol
August 18, 2020Molecular and Cellular Factors Associated with Racial Disparity in Breast Cancer.
Charan M, Verma AK, Hussain S, Misri S, Mishra S, Majumder S, Ramaswamy B, Ahirwar D, Ganju RK
Int J Mol Sci