Raphael E Pollock, MD, PhD
Leadership Title: Director, The Ohio State University Comprehensive Cancer Center Klotz Chair in Cancer Research
Academic Title: Professor in the College of Medicine
Research Program: Translational Therapeutics
Columbus, Ohio 43210-1228
About Me
More info forRaphael Pollock, MD, PhD, is a practicing surgical oncologist and director of The Ohio State University Comprehensive Cancer Center (OSUCCC). He is also a member of the Cancer Biology Program at the OSUCCC – James, where his research focuses on the molecular drivers underlying soft tissue sarcoma, a cancer of connective tissues that occurs throughout the body.
Dr. Pollock’s current studies include the role of MDM2 in dedifferentiated liposcaroma, circulating miRNA in soft tissue sarcoma and genetic determinants of desmoid tumor progression. These investigations are supported by a comprehensive soft tissue tumor acquisition program in collaboration with Hans Iwenofu, MD, of the Department of Pathology and Thomas Scharschmidt, MD, and Joel Mayerson, MD, of the Department of Orthopaedic Surgery. The retrieved tissues are used to create cell lines and cell strains. These tissues are also implanted in vivo to establish small animal models that support preclinical therapy investigations.
Dr. Pollock has authored or co-authored more than 400 original research and review articles as well as 21 books. He has shared his work in over 300 national and international presentations and visiting professorships involving professional audiences in 50 countries worldwide.
Clinical Expertise
More info for- Gastrointestinal Stromal Tumors
- Connective and Soft Tissue Cancers
- Sarcoma, Kaposi
- Muscle Tissue Cancers
- Spine Sarcoma
- Soft Tissue Cancers
- Myxosarcoma
- Osteosarcoma
Research Interests
More info for- Sarcoma
- Neoplasms
- Neurilemmoma
- Gastrointestinal Stromal Tumors
- Breast Neoplasms
- Leiomyosarcoma
- Neoplasm Metastasis
- Sarcoma, Ewing
- Liposarcoma, Myxoid
- Liposarcoma
Education & Training
More info forBA
- Oberlin College
Oberlin, OH
USA
MD
- St. Louis University School of Medicine
St. Louis, MO
USA
Fellowship - Fellowship in Surgical Oncology
- University of Texas M. D. Anderson Hospital and Tumor Institute
Houston, TX
USA
Residency - Basic Surgery Residency
- University of Chicago Hospitals and Clinics
Chicago, IL
USA
Residency - General Surgery Residency
- Rush-Presbyterian-St. Luke’s Medical Center
Chicago, IL
USA
- Oberlin College
Academic Office & Contact Information
More info forAcademic Office:
410 W 10th Ave
Columbus, Ohio 43210-1228Phone:
614-293-7171Email:
pollock.316@osu.eduPublications
More info forJuly 17, 2024Use of neoadjuvant paclitaxel in breast angiosarcoma-Impact on surgical resection and response rates.
Selby LV, Clark E, Chen JL, Tinoco G, Beane JD, Pollock RE, Liebner D, Grignol VP
J Surg Oncol
July 1, 2024Mechanical property estimation of sarcoma-relevant extracellular vesicles using transmission electron microscopy.
Singh PK, Sarchet P, Hord C, Casadei L, Pollock R, Prakash S
J Extracell Biol
May 21, 2024Extracellular Vesicle - MDM2-DNA as a Potential Liquid Biopsy Biomarker for Disease Identification in Retroperitoneal Liposarcoma.
Calore F, Casadei L, Sarchet PD, Fadda P, Nigita G, Coombes KR, Cascione L, Costas C de Faria F, Tahara S, Iwenofu OH, Pollock RE, Grignol VP
Ann Surg
March 24, 2024ASO Visual Abstract: Comparing Multivisceral Resection with Tumor-Only Resection of Liposarcoma Using the Win Ratio.
Gorji L, Nikahd M, Onuma A, Tsilimigras D, Hyer JM, Ruff S, Ilyas FZ, Contreras C, Grignol VP, Kim A, Pollock R, Pawlik TM, Beane JD
Ann Surg Oncol
March 21, 2024Progress in sarcomas: Highlights from the 2023 annual meetingof the Connective Tissue Oncology Society.
Cripe TP, Roberts RD, Chandler DS, Setty BA, Chen S, Shenoy A, Venkataramany AS, Ringwalt EM, Scharschmidt T, Utset-Ward T, Konieczkowski DJ, Grignol VP, Beane JD, Ruff SM, Pollock RE
Mol Ther Oncol
March 16, 2024Radiation therapy for retroperitoneal sarcoma: practice patterns in North America.
Ruff SM, Heh V, Konieczkowski DJ, Onuma A, Dunlop HM, Kim AC, Grignol VP, Contreras CM, Pawlik TM, Pollock R, Beane JD
Radiat Oncol
February 12, 2024Comparing Multivisceral Resection with Tumor-only Resection of Liposarcoma Using the Win Ratio.
Gorji L, Nikahd M, Onuma A, Tsilimigras D, Madison Hyer J, Ruff S, Ilyas FZ, Contreras C, Grignol VP, Kim A, Pollock R, Pawlik TM, Beane JD
Ann Surg Oncol
February 1, 2024Disparities in Survival and NCCN Guideline-Concordant Care in Patients With Extremity Soft Tissue Sarcoma.
Dunlop HM, Bende B, Ruff SM, Kim A, Fisher JL, Grignol VP, Contreras CM, Obeng-Gyasi S, Konieczkowski DJ, Pawlik TM, Pollock RE, Beane JD
J Natl Compr Canc Netw
February 1, 2024ISG15 mediates the function of extracellular vesicles in promoting ovarian cancer progression and metastasis.
Dorayappan KDP, Wagner V, Park D, Newcomer MM, Lightfoot MDS, Kalaiyarasan D, Sakaue T, Khadraoui W, Yu L, Wang QE, Maxwell GL, O'Malley D, Pollock RE, Cohn DE, Selvendiran K
J Extracell Biol
January 25, 2024ASO Visual Abstract: Adjuvant Palbociclib May be Associated with Delayed Recurrence in Completely Resected Retroperitoneal Liposarcoma: Results of a Single-Institution Retrospective Cohort Study.
Selby LV, Clark EC, Liebner DA, Chen JL, Tinoco G, Bashian E, Beane JD, Pollock RE, Grignol VP
Ann Surg Oncol
January 1, 2024Comparison of three-dimensional cell culture techniques of dedifferentiated liposarcoma and their integration with future research.
Tahara S, Sharma S, de Faria FCC, Sarchet P, Tomasello L, Rentsch S, Karna R, Calore F, Pollock RE
Front Cell Dev Biol
November 22, 2023Preoperative radiation therapy increases adherence in patients with high-risk extremity soft tissue sarcoma.
Dunlop HM, Atchison TJ, Zeh R, Konieczkowski DJ, Kim A, Grignol VP, Contreras CM, Obeng-Gyasi S, Pawlik TM, Pollock RE, Beane JD
Surgery
June 17, 2023Adjuvant Palbociclib May be Associated with Delayed Recurrence in Completely Resected Retroperitoneal Liposarcoma: Results of a Single-Institution Retrospective Cohort Study.
Selby LV, Clark EC, Liebner DA, Chen JL, Tinoco G, Bashian E, Beane JD, Pollock RE, Grignol VP
Ann Surg Oncol
May 26, 2023Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity.
Wang Y, Zhang H, La Ferlita A, Sp N, Goryunova M, Sarchet P, Hu Z, Sorkin M, Kim A, Huang H, Zhu H, Tsung A, Pollock RE, Beane JD
Oncogenesis
April 13, 2023Small Non-Coding RNAs in Soft-Tissue Sarcomas: State of the Art and Future Directions.
La Ferlita A, Sp N, Goryunova M, Nigita G, Pollock RE, Croce CM, Beane JD
Mol Cancer Res
March 11, 2023Emerging Trends in Immunotherapy for Adult Sarcomas.
Husain M, Chen L, Liebner D, Beane J, Rubinstein M, Pollock R, Verschraegen C, Tinoco G
Oncologist
January 1, 2023Erratum: ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage.
Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z
Am J Cancer Res
July 7, 2022The Role of AKT in Soft Tissue Sarcoma: Review and Insights.
Wang Y, Ilyas FZ, Kheradmandi M, Tsilimigras DI, Grignol VP, Contreras C, Tsichlis PN, Pollock RE, Beane JD
Mol Cancer Res
June 15, 2022Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Gounder MM, Agaram NP, Trabucco SE, Robinson V, Ferraro RA, Millis SZ, Krishnan A, Lee J, Attia S, Abida W, Drilon A, Chi P, Angelo SP, Dickson MA, Keohan ML, Kelly CM, Agulnik M, Chawla SP, Choy E, Chugh R, Meyer CF, Myer PA, Moore JL, Okimoto RA, Pollock RE, Ravi V, Singh AS, Somaiah N, Wagner AJ, Healey JH, Frampton GM, Venstrom JM, Ross JS, Ladanyi M, Singer S, Brennan MF, Schwartz GK, Lazar AJ, Thomas DM, Maki RG, Tap WD, Ali SM, Jin DX
Nat Commun
March 26, 2022Cancer-Derived Extracellular Vesicles: Their Role in Sarcoma.
Adib A, Sahu R, Mohta S, Pollock RE, Casadei L
Life (Basel)
March 17, 2022Correction: Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group.
Bagaria SP, Swallow C, Suraweera H, Raut CP, Fairweather M, Cananzi F, Quagliuolo V, Grignani G, Hompes D, Ford SJ, Nessim C, Apte S, Skoczylas J, Rutkowski P, Bonvalot S, Tzanis D, Gabriel E, Pennacchioli E, Albertsmeier M, Canter RJ, Pollock R, Grignol V, Cardona K, Gamboa AC, Novak M, Stoeckle E, Almquist M, Ahuja N, Klemen N, Van Houdt W, Gyorki D, Gangi A, Rastrelli M, van der Hage J, Schrage Y, Valeri S, Conti L, Spiegel MR, Li Z, Fiore M, Gronchi A
Ann Surg Oncol
March 8, 2022Targetable Pathways in the Treatment of Retroperitoneal Liposarcoma.
Casadei L, de Faria FCC, Lopez-Aguiar A, Pollock RE, Grignol V
Cancers (Basel)
January 1, 2022ATR inhibition sensitizes liposarcoma to doxorubicin by increasing DNA damage.
Cui J, Dean D, Hornicek FJ, Pollock RE, Hoffman RM, Duan Z
Am J Cancer Res
November 1, 2021Resection Status Does Not Impact Recurrence in Well-Differentiated Liposarcoma of the Extremity.
Olson CR, Suarez-Kelly LP, Ethun CG, Shelby RD, Yu PY, Hughes TM, Palettas M, Tran TB, Poultsides G, Tseng J, Roggin KK, Chouliaras K, Votanopoulos K, Krasnick BA, Fields RC, King DM, Bedi M, Pollock RE, Grignol VP, Cardona K, Howard JH
Am Surg
September 29, 2021Clinical biomarkers in soft tissue sarcoma A comprehensive review of current soft tissue sarcoma biomarkers.
Sharma SR, Paonessa NE, Casadei L, Costas De Faria F, Pollock RE, Grignol V
J Surg Oncol
August 2, 2021Disease Biology is "King" in Retroperitoneal Liposarcoma.
Tseng WW, Pollock RE, Grignol VP
Ann Surg Oncol
March 19, 2021Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group.
Bagaria SP, Swallow C, Suraweera H, Raut CP, Fairweather M, Cananzi F, Quagliuolo V, Grignani G, Hompes D, Ford SJ, Nessim C, Apte S, Skoczylas J, Rutkowski P, Bonvalot S, Tzanis D, Gabriel E, Pennacchioli E, Albertsmeier M, Canter RJ, Pollock R, Grignol V, Cardona K, Gamboa AC, Novak M, Stoeckle E, Almquist M, Ahuja N, Klemen N, Van Houdt W, Gyorki D, Gangi A, Rastrelli M, van der Hage J, Schrage Y, Valeri S, Conti L, Spiegel MR, Li Z, Fiore M, Gronchi A
Ann Surg Oncol
March 2, 2021Modern multimodality management of patients with caval leiomyosarcoma: New treatment paradigms and potential molecular insights.
Squires MH, Politano S, Pollock RE, Chen JL, Grignol V
J Surg Oncol
February 1, 2021Cross-flow microfiltration for isolation, selective capture and release of liposarcoma extracellular vesicles.
Casadei L, Choudhury A, Sarchet P, Mohana Sundaram P, Lopez G, Braggio D, Balakirsky G, Pollock R, Prakash S
J Extracell Vesicles
October 1, 2020Multi-Layer Micro-Nanofluidic Device for Isolation and Capture of Extracellular Vesicles Derived from Liposarcoma Cell Conditioned Media.
Sundaram PM, Casadei L, Lopez G, Braggio D, Balakirsky G, Pollock R, Prakash S
J Microelectromech Syst
July 10, 2020β-catenin S45F mutation results in apoptotic resistance.
Braggio D, Zewdu A, Londhe P, Yu P, Lopez G, Batte K, Koller D, Costas Casal de Faria F, Casadei L, Strohecker AM, Lev D, Pollock RE
Oncogene
June 7, 2020An EWSR1-CREB3L1 Fusion Gene in Extraskeletal Undifferentiated Round Cell Sarcoma Expands the Spectrum of Genetic Landscape in the "Ewing-Like" Undifferentiated Round Cell Sarcomas.
Bissonnette C, Shilo K, Liebner D, Rogers A, Pollock RE, Iwenofu OH
Int J Surg Pathol
June 5, 2020Activity of PD1 inhibitor therapy in advanced sarcoma: a single-center retrospective analysis.
Quiroga D, Liebner DA, Philippon JS, Hoffman S, Tan Y, Chen JL, Lenobel S, Wakely PE, Pollock R, Tinoco G
BMC Cancer
May 26, 2020Extracellular vesicle cross-talk in the liposarcoma microenvironment.
Casadei L, Pollock RE
Cancer Lett
April 23, 2020Enhancing Antitumor Efficacy of Heavily Vascularized Tumors by RAMBO Virus through Decreased Tumor Endothelial Cell Activation.
Nair M, Khosla M, Otani Y, Yeh M, Park F, Shimizu T, Kang JM, Bolyard C, Yu JG, Kumar Banasavadi-Siddegowda Y, Lopez G, Kaur B, Pollock RE, Lee TJ, Old M, Yoo JY
Cancers (Basel)
March 30, 2020Neoadjuvant radiation improves margin-negative resection rates in extremity sarcoma but not survival.
Shelby RD, Suarez-Kelly LP, Yu PY, Hughes TM, Ethun CG, Tran TB, Poultsides G, King DM, Bedi M, Mogal H, Clarke C, Tseng J, Roggin KK, Chouliaras K, Votanopoulos K, Krasnick BA, Fields RC, Pollock RE, Howard JH, Cardona K, Grignol V
J Surg Oncol