Stefan Niewiesk, DVM, PhD
Academic Title: Professor
Research Program: Leukemia and Hematologic Malignancies
I am a member of the Leukemia and Hematologic Malignancies Program at the OSUCCC – James, where my research explores the use of measles vaccine virus as oncolytic therapy for T-cell leukemia.
In particular, I use a mouse model of adult T-cell leukemia to understand the interaction between tumor cells, microenvironment and virus. Other aspects of this research are how to use genetically improved viruses to combat leukemia and how to combine viral oncolytic therapy with other conventional or experimental therapies.
I have co-authored many articles in well-known publications, including Institute for Laboratory Animal Research Journal, Journal of Virology, Immunology and Virus Research.
- Infection
- Vesicular Stomatitis
- Encephalitis
- Paraparesis, Tropical Spastic
- Paramyxoviridae Infections
- Measles
Academic Office:
1900 Coffey Rd
Columbus, Ohio 43210-1006Phone:
614-688-3605Email:
niewiesk.1@osu.edu- October 9, 2024
Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry.
Stearns K, Lampe G, Hanan R, Marcink T, Niewiesk S, Sternberg SH, Greninger AL, Porotto M, Moscona A
mBio
June 28, 2024A neutralizing antibody prevents postfusion transition of measles virus fusion protein.
Zyla DS, Della Marca R, Niemeyer G, Zipursky G, Stearns K, Leedale C, Sobolik EB, Callaway HM, Hariharan C, Peng W, Parekh D, Marcink TC, Diaz Avalos R, Horvat B, Mathieu C, Snijder J, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Ollmann Saphire E
Science
January 9, 2024An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits.
Tu JJ, King E, Maksimova V, Smith S, Macias R, Cheng X, Vegesna T, Yu L, Ratner L, Green PL, Niewiesk S, Richner JM, Panfil AR
J Virol
January 1, 2024Epigallocatechin gallate regulates the myeloid-specific transcription factor PU.1 in macrophages.
Karpurapu M, Kakarala KK, Chung S, Nie Y, Koley A, Dougherty P, Christman JW
PLoS One
June 1, 2023HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development.
Maksimova V, Wilkie T, Smith S, Phelps C, Melvin C, Yu L, Niewiesk S, Green PL, Panfil AR
PLoS Pathog
September 6, 2022Codon-optimization of the respiratory syncytial virus (RSV) G protein expressed in a vesicular stomatitis virus (VSV) vector improves immune responses in a cotton rat model.
Brakel KA, Ma Y, Binjawadagi R, Harder O, Watts M, Li J, Binjawadagi B, Niewiesk S
Virology
August 13, 2021Nonsteroidal anti-inflammatory drugs restore immune function to respiratory syncytial virus in geriatric cotton rats (Sigmodon hispidus).
Harder OE, Martinez M, Niewiesk S
Virology