Wendy L Frankel, MD
Physician
Specialty:Pathology
Gender: female
Academic Title: Professor and Chair
Research Program: Translational Therapeutics
About Me
More info forI am a pathologist specializing in patients with pancreatic diseases and gastrointestinal cancers and diseases. I serve as a Distinguished Professor and Chair of the Department of Pathology, the Ralph W. and Helen Kurtz Chair in Pathology, and the director of the GI/Liver Pathology Fellowship at The Ohio State University. I received my medical degree from the University of Michigan and trained in surgery at the Hospital of the University of Pennsylvania. I completed my residency in pathology at University of California San Diego and my surgical pathology fellowship at the University of California San Francisco. As a member of the Translational Therapeutics Program at the OSUCCC – James, my research focuses on colorectal carcinoma, specifically in the area of colon cancer genetics. I was part of the Columbus-area Hereditary Non-Polyposis Colorectal Cancer (HNPCC) study that changed the standard of care for colorectal cancer patients in the United States. I am also involved with the Ohio Colorectal Cancer Prevention Initiative (OCCPI), which screens newly diagnosed colorectal cancer patients across the state and their at-risk relatives for Lynch syndrome. Over the course of my career, I have published more than 200 papers and given multiple lectures both nationally and internationally. What I love most about working at the OSUCCC – James is the community of experienced medical professionals, researchers and caring staff. At The James, we have access to the latest research and technology, and together, we use these resources to provide targeted treatment plans to our patients. Each person’s cancer is different, and we treat each patient according to their needs. Together, we’re working towards a cancer-free world, and I’m proud to be a part of this mission.
Clinical Expertise
More info for- Gastrointestinal Cancers
- Pancreatic Diseases
- Gastrointestinal Diseases
Research Interests
More info for- Polyps
- Colorectal Neoplasms
- Microsatellite Instability
- Carcinoma
- Neoplasms
- Adenoma
- Adenocarcinoma
- Pancreatic Neoplasms
- Carcinoma, Hepatocellular
- Colorectal Neoplasms, Hereditary Nonpolyposis
Education & Training
More info forFellowship - Surgery (General Surgery)
- Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia, PA
Residency - Surgery (General Surgery)
- Hospital of the University of Pennsylvania
3400 Spruce St, Philadelphia, PA
Residency - Pathology, Anatomic Pathology & Clinical Pathology
- University of California Medical Center San Diego
200 West Arbor Dr, San Diego, CA
Fellowship - Surgical Pathology
- University of California San Francisco School of Medicine
500 Parnassus Ave, San Francisco, CA
Medical School
- University of Michigan Medical School
1301 Catherine St, Ann Arbor, MI
- Hospital of the University of Pennsylvania
Academic Office & Contact Information
More info forAcademic Office:
Optometry Clinic
1664 Neil Ave
Columbus, Ohio 43201Phone:
614-346-9189Email:
frankel.15@osu.eduPublications
More info forOctober 7, 2024Validation of Metallothionein Immunohistochemistry as a Highly Sensitive Screening Test for Wilson Disease.
Stokes NL, Patil A, Adeyi O, Bhalla A, Brown I, Byrnes K, Calderaro J, Chen D, Chen W, Cooper C, Dhall D, Frankel W, Gooch GG, Gonzalez RS, Hammer S, Hale G, Lagana S, McKenzie C, Allende DS, Moreira RK, Nakhleh R, Nalbantoglu I, Pai RK, Salomao M, Schaeffer DF, Shih A, Shin JS, Simoes CC, Vij M, Rela M, Xue Y, Yantiss RK, Sabatto BZ, Graham RP
Mod Pathol
July 8, 2024IL-27 Gene Therapy Ameliorates IPEX Syndrome Caused by Germline Mutation of Foxp3 Gene: A Major Role for Induction of IL-10.
Liu JQ, Jabbari A, Lin CH, Akkanapally V, Frankel WL, Basu S, He K, Zheng P, Liu Y, Bai XF
Journal of Immunology
June 28, 2024EPM2AIP1 Immunohistochemistry Is Inadequate as A Surrogate Marker for MLH1 Promoter Hypermethylation Testing in Colorectal Cancer.
Challa B, Frankel WL, Knight D, Pearlman R, Hampel H, Chen W
Hum Pathol
May 13, 2024Intraoperative Frozen Section Evaluation of Pancreatic Specimens and Related Liver Lesions.
Vazzano J, Chen W, Frankel WL
Arch Pathol Lab Med
February 1, 2024Enhancing Colorectal Cancer Tumor Bud Detection Using Deep Learning from Routine H&E-Stained Slides.
Sajjad U, Chen W, Rezapour M, Su Z, Tavolara T, Frankel WL, Gurcan MN, Niazi MKK
Proc SPIE Int Soc Opt Eng
February 1, 2024Few-shot Tumor Bud Segmentation Using Generative Model in Colorectal Carcinoma.
Su Z, Chen W, Leigh PJ, Sajjad U, Niu S, Rezapour M, Frankel WL, Gurcan MN, Niazi MKK
Proc SPIE Int Soc Opt Eng
February 1, 2024Adapting SAM to Histopathology Images for Tumor Bud Segmentation in Colorectal Cancer.
Su Z, Chen W, Annem S, Sajjad U, Rezapour M, Frankel WL, Gurcan MN, Niazi MKK
Proc SPIE Int Soc Opt Eng
October 13, 2023Comparing Accuracy of Helicobacter pylori Identification Using Traditional Hematoxylin and Eosin (H&E)-stained Glass Slides with Digital Whole Slide Imaging.
Chen W, Ziebell J, Arole V, Parkinson B, Yu L, Dai H, Frankel WL, Yearsley M, Esnakula A, Sun S, Gamble D, Vazzano J, Mishra M, Schoenfield L, Kneile J, Reuss S, Schumacher M, Satturwar S, Li Z, Parwani A, Lujan G
Lab Invest
July 28, 2022Neuropeptide Y, a paracrine factor secreted by cancer cells, is an independent regulator of angiogenesis in colon cancer.
Chakroborty D, Goswami S, Fan H, Frankel WL, Basu S, Sarkar C
Br J Cancer
July 14, 2022Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas: The A021501 Phase 2 Randomized Clinical Trial.
Katz MHG, Shi Q, Meyers J, Herman JM, Chuong M, Wolpin BM, Ahmad S, Marsh R, Schwartz L, Behr S, Frankel WL, Collisson E, Leenstra J, Williams TM, Vaccaro G, Venook A, Meyerhardt JA, O'Reilly EM
JAMA Oncol
June 23, 2022Universal tumor screening for lynch syndrome on colorectal cancer biopsies impacts surgical treatment decisions.
Vazzano J, Tomlinson J, Stanich PP, Pearlman R, Kalady MF, Chen W, Hampel H, Frankel WL
Fam Cancer
June 2, 2021Randomized Phase II Study of PET Response-Adapted Combined Modality Therapy for Esophageal Cancer: Mature Results of the CALGB 80803 (Alliance) Trial.
Goodman KA, Ou FS, Hall NC, Bekaii-Saab T, Fruth B, Twohy E, Meyers MO, Boffa DJ, Mitchell K, Frankel WL, Niedzwiecki D, Noonan A, Janjigian YY, Thurmes PJ, Venook AP, Meyerhardt JA, O'Reilly EM, Ilson DH
J Clin Oncol
March 26, 2021Pancreatic Frozen Section Guides Operative Management With Few Deferrals and Errors.
Chavez JA, Chen W, Freitag CE, Frankel WL
Arch Pathol Lab Med
January 28, 2021Histopathological Diagnosis of Tumour Deposits in Colorectal Cancer: A Delphi Consensus Study.
Lord A, Brown G, Abulafi M, Bateman A, Frankel W, Goldin R, Gopal P, Kirsch R, Loughrey MB, Märkl B, Moran B, Puppa G, Rasheed S, Shimada Y, Snaebjornsson P, Svrcek M, Washington K, West N, Wong N, Nagtegaal I
Histopathology
January 1, 2021Double somatic mismatch repair gene pathogenic variants as common as Lynch syndrome among endometrial cancer patients.
Hampel H, Pearlman R, de la Chapelle A, Pritchard CC, Zhao W, Jones D, Yilmaz A, Chen W, Frankel WL, Suarez AA, Cosgrove C, Backes F, Copeland L, Fowler J, O'Malley D, Salani R, McElroy JP, Stanich PP, Goodfellow P, Cohn DE
Gynecol Oncol
January 1, 2021Using Endoscopic Optical Coherence Tomography to Detect and Treat Early-Stage Pancreatic Cancers.
Lu L, Hu Z, Frankel W, Shen R, Chen W, Pan X, Grecula JC, Bloomston MP, Dillhoff ME
Front Oncol
January 1, 2021Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.
Pearlman R, Frankel WL, Swanson BJ, Jones D, Zhao W, Yilmaz A, Miller K, Bacher J, Bigley C, Nelsen L, Goodfellow PJ, Goldberg RM, Paskett E, Shields PG, Freudenheim JL, Stanich PP, Lattimer I, Arnold M, Prior TW, Haut M, Kalady MF, Heald B, Paquette I, Draper DJ, Brell JM, Mahesh S, Weeman K, Bastola S, Zangmeister J, Gowda A, Kencana F, Malcolm A, Liu Y, Cole S, Bane C, Li C, Rehmus E, Pritchard CC, Shirts BH, Jacobson A, Cummings SA, de la Chapelle A, Hampel H
JCO Precis Oncol
November 24, 2020Morphologic Changes Associated with Neoadjuvant-Treated Pancreatic Ductal Adenocarcinoma and Comparison of Two Tumor Regression Grading Systems.
Vazzano J, Frankel WL, Wolfe AR, Williams TM, Chen W
Hum Pathol
August 13, 2020Activation of the RAS pathway through uncommon BRAF mutations in mucinous pancreatic cysts without KRAS mutation.
Ren R, Krishna SG, Chen W, Frankel WL, Shen R, Zhao W, Avenarius MR, Garee J, Caruthers S, Jones D
Mod Pathol
July 8, 2020Unexpected Expression of Mismatch Repair Protein Is More Commonly Seen with Pathogenic Missense than Other Mutations in Lynch Syndrome.
Chen W, Hampel H, Pearlman R, Jones D, Zhao W, Alsomali M, Knight D, Frankel WL
Hum Pathol
May 16, 2020Neoadjuvant-modified FOLFIRINOX vs nab-paclitaxel plus gemcitabine for borderline resectable or locally advanced pancreatic cancer patients who achieved surgical resection.
Wolfe AR, Prabhakar D, Yildiz VO, Cloyd JM, Dillhoff M, Abushahin L, Alexandra Diaz D, Miller ED, Chen W, Frankel WL, Noonan A, Williams TM
Cancer Med
April 21, 2020Perineural invasion predicts for locoregional failure in patients with oesophageal adenocarcinoma treated with neoadjuvant chemoradiotherapy.
Patel AK, Pan X, Vila DM, Frankel WL, Chen W, Perry KA, Merritt RE, D'Souza DM, Wuthrick EJ, Williams TM
J Clin Pathol
April 16, 2020PD-1 and PD-L1 expression in PD-1 Inhibitor-Associated Colitis and Its Mimics.
Cassol CA, Owen D, Kendra K, Braga JR, Frankel WL, Arnold CA
Histopathology
Consulting and Related Relationships
More info forAt The Ohio State University Wexner Medical Center, we support a faculty member’s research and consulting in collaboration with medical device, research and/or drug companies because a faculty member’s expertise can guide important advancements in the practice of medicine and improve patient care. In order to provide effective management of these relationships, the university requires annual disclosures from all faculty members with external interests related to their university responsibilities. As of 09/30/2024, Dr. Frankel has reported relationships with the companies or entities listed below. If you have questions about the relationships listed below, please ask the faculty member. If you have questions about how these relationships are monitored by The Ohio State University Wexner Medical Center, please contact our Compliance Office.
- United States and Canadian Academy of Pathology
- The University of Texas M.D. Anderson Cancer Center