Acharya Lab

Research and Discoveries

Learn about the research projects being conducted at the Acharya Lab.

An assistant professor in the Department of Neurology and a member of the Pelotonia Institute for Immuno-Oncology, Dr. Acharya is an accomplished cancer research specialist who brings an impressive catalogue of patents and publications.

Patents include:

  • Pramod Srivastava, Nandini Acharya, Sreyashi Basu, “Methods of treatment of inflammation of the gut” US Patent App. 15/147,022.
  • Ana Carrizosa Anderson, Asaf Madi, Nandini Acharya, Vijay K. Kuchroo, Aviv Regev, “Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis” U.S. Provisional Application No. 62/911,957

Original research articles include:

  • Nandini Acharya, Sasi Penukonda, Tatiana Shcheglova, Adam T Hagymasi, Sreyashi Basu, Pramod K Srivastava “ The endocannabinoid system acts as a regulator of immune homeostasis in the gut” PNAS, 2017.
  • Catherine A Sabatos-Peyton, James Nevin, Ansgar Brock, John D Venable, Dewar J Tan, Nasim Kassam, Fangmin Xu, John Taraszka, Luke Wesemann, Thomas Pertel, Nandini Acharya, Max Klapholz, Yassaman Etminan, Xiaomo Jiang, Yu-Hwa Huang, Richard S Blumberg, Vijay K Kuchroo, Ana C Anderson. “Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy”. Oncoimmunology, 2018.
  • Norio Chihara, Asaf Madi,Takaaki Kondo, Huiyuan Zhang, Nandini Acharya, Meromit Singer, Jackson Nyman, Nemanja D. Marjanovic, Monika S. Kowalczyk, Chao Wang, Sema Kurtulus, Travis Law, Yasaman Etminan, James Nevin, Christopher D. Buckley, Patrick R. Burkett, Jason D. Buenrostro, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev, and Vijay K. Kuchroo. “Induction and transcriptional regulation of the co-inhibitory gene module in T cells”. Nature, 2018.
  • Nandini Acharya, Asaf Madi, Huiyuan Zhang, Max Klapholz, Giulia Escobar, Shai Dolberg, Elena Christian, Michelle Ferreira, Karen O. Dixon, Geoffrey Fell, Katherine Tooley, Davide Mangani, Junrong Xia, Meromit Singer, Marcus Bosenberg, Donna Neuberg, Orit Rozenblatt-Rosen, Aviv Regev, Vijay K. Kuchroo, and Ana C. Anderson  “Endogenous glucocorticoid signaling regulates effector differentiation and development of dysfunction in CD8+ T cells in the tumor microenvironment”. Immunity, 2020.
  • Huiyuan Zhang, Asaf Madi, Nir Yosef, Norio Chihara, Amit Awasthi,, Caroline Pot, Conner Lambden, Amitabh Srivastava, Patrick R. Burkett,  Jackson Nyman, Elena Christian, Yasaman Etminan, Annika Lee, Helene Stroh, Junrong Xia, Katarzyna Karwacz, Pratiksha I. Thakore, Nandini Acharya, Alexandra Schnell, Chao Wang, Lionel Apetoh, Orit Rozenblatt-Rosen, Ana C. Anderson, Aviv Regev, Vijay K. Kuchroo. “An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets”. Cell Reports, 2020.
  • Ruihan Tang, Nandini Acharya, Ayshwarya Subramanian, Vinee Purohit, Marcin Tabaka, Yu Hou, Danyang He, Karen O Dixon, Connor Lambden, Junrong Xia, Orit Rozenblatt-Rosen, Raymond A Sobel, Chao Wang, Aviv Regev, Ana C Anderson, Vijay K Kuchroo. “Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function”. Science Immunology, 2022.
  • Nandini Acharya and Ana C. Anderson “New Clones on the block”, Immunity, 2019.
  • Nandini Acharya, Catherine A. Sabatos-Peyton and Ana C. Anderson “Tim-3 finds its place in the cancer immunotherapy landscape” Journal for ImmunoTherapy of Cancer, 2020.
  • Nandini Acharya and Ana C. Anderson “NRP1cripples immunological memory” Nature Immunology, 2020.